高酮血症抑制过渡期奶牛中性粒细胞胞外诱捕网形成的机制
31672621
2016
C1809.临床兽医学
刘国文
面上项目
教授
吉林大学
63万元
酮病;家畜;先天免疫抑制;中性粒细胞胞外诱捕网;致病机理
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows | 期刊论文 | Shen Taiyu;Li Xinwei;Loor Juan J;Zhu Yiwei;Du Xiliang;Wang Xinghui;Xing Dongmei;Shi Zhen;Fang Zhiyuan;Li Xiaobing;Liu Guowen |
| 2 | Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows | 期刊论文 | Du Xiliang;Shi Zhen;Peng Zhicheng;Zhao Chenxu;Zhang Yuming;Wang Zhe;Li Xiaobing;Liu Guowen;Li Xinwei |
| 3 | Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice | 期刊论文 | Li Xinwei;Shi Zhen;Zhu Yiwei;Shen Taiyu;Wang Heyuan;Shui Guanghou;Loor Juan J.;Fang Zhiyuan;Chen Meng;Wang Xinghui;Peng Zhicheng;Song Yuxiang;Wang Zhe;Du Xiliang;Liu Guowen |
| 4 | Elevated Apoptosis in the Liver of Dairy Cows with Ketosis | 期刊论文 | Du Xiliang;Chen Liang;Huang Dan;Peng Zhicheng;Zhao Chenxu;Zhang Yuming;Zhu Yiwei;Wang Zhe;Li Xinwei;Liu Guowen |
| 5 | High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis | 期刊论文 | Sun Xudong;Wang Yazhe;Loor Juan J;Bucktrout Ryan;Shu Xin;Jia Hongdou;Dong Jihong;Zuo Rankun;Liu Guowen;Li Xiaobing;Li Xinwei |
| 6 | Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway | 期刊论文 | Li Yu;Ding Hongyan;Liu Leihong;Song Yuxiang;Du Xiliang;Feng Shibin;Wang Xichun;Li Xiaobing;Wang Zhe;Li Xinwei;Li Jinchun;Wu Jinjie;Liu Guowen |
| 7 | Geniposide alleviates non‐alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways | 期刊论文 | Bingyu Shen;Haihua Feng;Jiaqi Cheng;Zheng Li;Meiyu Jin;Lilei Zhao;Qi Wang;Haiyan Qin;Guowen Liu |
| 8 | 高浓度非酯化脂肪酸诱导Ⅱ型酮病奶牛氧化应激 | 期刊论文 | 李重邑;陈琳方;刘国文 |
| 9 | Subacute ruminal acidosis suppressed the expression of MCT1 in rumen of cows | 期刊论文 | Zhao Chenxu;Wang Yazhou;Peng Zhicheng;Sun Xudong;Sun Guoquan;Yuan Xue;Li Xinwei;Liu Guowen |
| 10 | NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis | 期刊论文 | Gao Wenwen;Du Xiliang;Lei Lin;Wang Heyuan;Zhang Min;Wang Zhe;Li Xiaobing;Liu Guowen;Li Xinwei |
| 11 | Effect of heat-shock protein B7 on oxidative stress in adipocytes from preruminant calves | 期刊论文 | Sun Xudong;Li Xiaobing;Jia Hongdou;Loor Juan J.;Bucktrout Ryan;Xu Qiushi;Wang Yazhe;Shu Xin;Dong Jihong;Zuo Rankun;Yang Liangyu;Liu Guowen;Li Xinwei |
| 12 | Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis | 期刊论文 | Du Xiliang;Yang Yuchen;Xu Chuang;Peng Zhicheng;Zhang Min;Lei Lin;Gao Wenwen;Dong Yuhao;Shi Zhen;Sun Xudong;Wang Zhe;Li Xiaobing;Li Xinwei;Liu Guowen |
| 13 | Hepatic miR-125b inhibits insulin signaling pathway by targeting PIK3CD | 期刊论文 | Du Xiliang;Li Xiaobing;Chen Liang;Zhang Min;Lei Lin;Gao Wenwen;Shi Zhen;Dong Yuhao;Wang Zhe;Li Xinwei;Liu Guowen |
| 14 | Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows | 期刊论文 | Zhu Yiwei;Guan Yuan;Loor Juan J;Sha Xueying;Coleman Danielle N;Zhang Cai;Du Xiliang;Shi Zhen;Li Xiaobing;Wang Zhe;Liu Guowen;Li Xinwei |
| 15 | The effects of non-esterified fatty acids and beta-hydroxybutyrate on the hepatic CYP2E1 in cows with clinical ketosis | 期刊论文 | Peng Zhicheng;Li Xiaobing;Wang Zhe;Liu Guowen;Li Xinwei |
| 16 | Berberine inhibits lipopolysaccharide-induced expression of inflammatory cytokines by suppressing TLR4-mediated NF-B and MAPK signaling pathways in rumen epithelial cells of Holstein calves | 期刊论文 | Zhao Chenxu;Wang Yazhou;Yuan Xue;Sun Guoquan;Shen Bingyu;Xu Feng;Fan Guyue;Jin Meiyu;Li Xinwei;Liu Guowen |
| 17 | Nobiletin alleviates palmitic acid-induced NLRP3 inflammasome activation in a sirtuin 1-dependent manner in AML-12 cells | 期刊论文 | Peng Zhicheng;Li Xiaobing;Xing Dongmei;Du Xiliang;Wang Zhe;Liu Guowen;Li Xinwei |
| 18 | High concentrations of fatty acids and beta-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows | 期刊论文 | Du Xiliang;Zhu Yiwei;Peng Zhicheng;Cui Yuanxu;Zhang Qiang;Shi Zhen;Guan Yuan;Sha Xueying;Shen Taiyu;Yang Yuchen;Li Xiaobing;Wang Zhe;Li Xinwei;Liu Guowen |
| 19 | Rosmarinic acid protects mice from lipopolysaccharide/D-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-kappa B and activating Nrf2/HO-1 signaling pathways | 期刊论文 | Li Zheng;Feng Haihua;Wang Yue;Shen Bingyu;Tian Ye;Wu Lin;Zhang Qiaoling;Jin Meiyu;Liu Guowen |
| 20 | Nuclear Factor E2-Related Factor 2 Mediates Oxidative Stress-Induced Lipid Accumulation in Adipocytes by Increasing Adipogenesis and Decreasing Lipolysis | 期刊论文 | Sun Xudong;Li Xiaobing;Jia Hongdou;Wang Heyuan;Shui Guanghou;Qin Yonglei;Shu Xin;Wang Yazhe;Dong Jihong;Liu Guowen;Li Xinwei |
| 21 | Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation | 期刊论文 | Meiyu Jin;Haihua Feng;Yue Wang;Siru Yan;Bingyu Shen;Zheng Li;Haiyan Qin;Qi Wang;Jinxia Li;Guowen Liu |
| 22 | Expression patterns of hepatic genes involved in lipid metabolism in cows with subclinical or clinical ketosis | 期刊论文 | Zhu Yiwei;Liu Guowen;Du Xiliang;Shi Zhen;Jin Meiyu;Sha Xueying;Li Xiaobing;Wang Zhe;Li Xinwei |
| 23 | Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF-Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows | 期刊论文 | Yuming Zhang;Xiaobing Li;Haolong Zhang;Zhibo Zhao;Zhicheng Peng;Zhe Wang;Guowen Liu;Xinwei Li |
| 24 | Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d ‐galactosamine induced acute liver injury | 期刊论文 | Zheng Li;Haihua Feng;Lu Han;Lu Ding;Bingyu Shen;Ye Tian;Lilei Zhao;Meiyu Jin;Qi Wang;Haiyan Qin;Jiaqi Cheng;Guowen Liu |
| 25 | 高乙酰乙酸诱导中性粒细胞胞外诱捕网的形成 | 期刊论文 | 崔媛旭;张强;范古玥;杨宇宸;金美玉;叶倩倩;李心慰;刘国文 |
| 26 | Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly | 期刊论文 | Jia Hongdou;Li Xiaobing;Liu Guowen;Loor Juan J;Bucktrout Ryan;Sun Xudong;Li Guojin;Shu Xin;Dong Jihong;Wang Yazhe;Zuo Rankun;Wang Zhe;Li Xinwei |
| 27 | Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor alpha Activation | 期刊论文 | Tian Ye;Feng Haihua;Han Lu;Wu Lin;Lv Hongming;Shen Bingyu;Li Zheng;Zhang Qiaoling;Liu Guowen |
| 28 | Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver | 期刊论文 | Du Xiliang;Shen Taiyu;Wang Heyuan;Qin Xia;Xing Dongmei;Ye Qianqian;Shi Zhen;Fang Zhiyuan;Zhu Yiwei;Yang Yuchen;Peng Zhicheng;Zhao Chenxu;Lv Bin;Li Xiaobing;Liu Guowen;Li Xinwei |
| 29 | Impaired hepatic autophagic activity in dairy cows with severe fatty liver is associated with inflammation and reduced liver function | 期刊论文 | Du Xiliang;Liu Guowen;Loor Juan J;Fang Zhiyuan;Bucktrout Ryan;Yang Yuchen;Ye Qianqian;Shi Zhen;Shen Taiyu;Wang Xinghui;Peng Zhicheng;Zhao Chenxu;Lv Bin;Xing Dongmei;Zhu Yiwei;Li Xiaobing;Li Xinwei |
| 30 | Glucagon attenuates lipid accumulation in cow hepatocytes through AMPK signaling pathway activation | 期刊论文 | Li Yu;Ding Hongyan;Dong Jihong;Rahman Sajid Ur;Feng Shibin;Wang Xichun;Wu Jinjie;Wang Zhe;Liu Guowen;Li Xiaobing;Li Xinwei |
| 31 | Potential Role of SLC5A8 Expression in the Etiology of Subacute Ruminal Acidosis | 期刊论文 | Zhao Chenxu;Bobe Gerd;Wang Yazhou;Zhang Xinyue;Zhao Zhibo;Zhang Shiqi;Sun Guoquan;Yuan Xue;Li Xinwei;Liu Guowen |
| 32 | 2020年吉林省自然科学一等奖 | 奖励 | 刘国文;李心慰;李小兵;王哲;杜希良;宋玉祥 |
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