肿瘤靶向抗CDK4胞内抗体抑制肿瘤转移的作用效能及分子调控机制
31570934
2015
C0808.疫苗、抗体与免疫干预
李桂英
面上项目
教授
吉林大学
60万元
肿瘤转移;胞内抗体;分子机制;蛋白质相互作用组学;CDK4
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1 | 期刊论文 | Tian Yuan;Guo Yantong;Zhu Pei;Zhang Dongxu;Liu Shanshan;Tang Mengyan;Wang Yuanxin;Jin Zheng;Li Dong;Yan Dongmei;Li Guiying;Zhu Xun |
| 2 | 靶向CDK4胞内抗体的制备及其抑瘤效应分析 | 会议论文 | 赵佳亮;朱迅;廖祥志;张影;汤巍巍;冯晶;王琪;许晶晶;杨丹;李桂英 |
| 3 | Prokaryotic expression, purification and characterization of human cyclooxygenase-2 | 期刊论文 | Liao Xiangzhi;Wang Wenhan;Fan Chuanxi;Yang Ning;Zhao Jialiang;Zhang Ying;Gao Ruijuan;Shen Guannan;Xia Simin;Li Guiying |
| 4 | Subunits of human condensins are potential therapeutic targets for cancers | 期刊论文 | Hongzhen Wang;Sihan Yang;Guiying Li;Xudong Cao |
| 5 | Targeting the cyclin D1-cyclin-dependent kinase (CDK) 4 kinase complex with the intrabody | 会议论文 | Ying Zhang;Yan Wu;Xun Zhu;Bingqian Zhang;Weiwei Tang;An Cui;Xiangzhi Liao;Ruijuan Gao;Simin Xia;Guiying Li |
| 6 | Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1 alpha | 期刊论文 | Zhao Liangzhong;Liu Ziyu;Yang Fang;Zhang Ying;Xue Ying;Miao Haipeng;Liao Xiangzhi;Huang Hongli;Li Guiying |
| 7 | Effects of metal ions on the structure and activity of a human anti-cyclin D1 single-chain variable fragment AD5 | 期刊论文 | Yang Ning;Yao Nannan;Liao Xiangzhi;Xie Xiaona;Wu Yan;Fan Chuanxi;Zhao Jialiang;Li Guiying |
| 8 | Characterization of the intrabody targeting PHD2 | 奖励 | Liangzhong Zhao;Ziyu Liu;Ruijuan Gao;Ying Zhang;Haipeng Miao;Ying Xue;Hongli Huang;Fang Yang;Guiying Li |
| 9 | An intrabody blocking cyclooxygenase-2 activity both in vitro and in vivo | 会议论文 | Guiying Li |
| 10 | 一种人源单链抗体及其应用 | 专利 | 李桂英;赵良中;郜瑞娟;赵佳亮;刘子钰;琚常青 |
| 11 | 细胞内HIF脯氨酰羟化酶抑制剂的制备及活性分析 | 会议论文 | 赵良中;郜瑞娟;赵佳亮;刘子钰;张影;李承娟;王曼宁;王帅;杨方;李桂英 |
| 12 | 靶向CDK4胞内抗体治疗乳腺癌研究 | 会议论文 | 赵佳亮;廖祥志;杨方;张影;赵良中;薛莹;仲文;田媛;黄红丽;李桂英 |
| 13 | Characterization of the intrabody targeting PHD2 | 会议论文 | Liangzhong Zhao;Ziyu Liu;Ruijuan Gao;Ying Zhang;Haipeng Miao;Ying Xue;Hongli Huang;Fang Yang;Guiying Li |
| 14 | TRIM59: A membrane protein expressed on Bacillus Calmette-Guerin-activated macrophages that induces apoptosis of fibrosarcoma cells by direct contact | 期刊论文 | Tian Yuan;Jin Zheng;Zhu Pei;Liu Shanshan;Zhang Dongxu;Tang Mengyan;Wang Yuanxin;Li Dong;Yan Dongmei;Li Guiying;Zhu Xun |
| 15 | Exosome separation using microfluidic systems: size-based, immunoaffinity-based and dynamic methodologies | 期刊论文 | Yang Fang;Liao Xiangzhi;Tian Yuan;Li Guiying |
| 16 | 靶向Cyclin D1-CDK4激酶复合物的胞内抗体 | 会议论文 | 李桂英 |
| 17 | An intrabody against PHD2 protects against acute liver injury in mice | 奖励 | Liangzhong Zhao;Ziyu Liu;Guoxiu Zhao;Ying Zhang;Haipeng Miao;Ying Xue;Hongli Huang;Fang Yang;Cynthia Ju;Guiying Li |
| 18 | The Tumor-specific intrabody against cyclin-dependent kinase (CDK) 4 inhibit proliferation and migration of breast cancer cells | 会议论文 | Xiangzhi Liao;Ying Zhang;Xun Zhou;Luwei Huang;Chuanxi Fan;Weiwei Tang;An Cui;Haipeng Miao;Ying xue;Jialiang Zhao;Liangzhong Zhao;Guiying Li |
| 19 | Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis | 期刊论文 | Liangzhong Zhao;Jialiang Zhao Ruijuan Gao;Yuan Tian Ying Zhang Weiwei Tang;Yu Jiang Chengjuan Li Manning Wang Fang Yang;Guiying Li |
| 20 | 靶向Cyclin D1-CDK4激酶复合物的肝癌治疗研究 | 会议论文 | 薛莹;苗海鹏;夏思敏;武艳;赵佳亮;张影;赵良中;杨方;李桂英 |
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