miR-30a/BCL11A调控MDM2-P53通路介导慢性髓系白血病伊马替尼耐药机制的研究
81770126
2017
H0808.骨髓增殖性肿瘤
徐兵
面上项目
主任医师
厦门大学
58万元
miR-30a;伊马替尼;BCL11A;慢性髓系胞白血病
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Vδ2 T cell subsets, defined by PD-1 and TIM-3 expression, present varied cytokine responses in acute myeloid leukemia patients | 期刊论文 | Kangni Wu;Juan Feng;Yanghui Xiu;Zhifeng Li;Zhijuan Lin;Haijun Zhao;Hanyan Zeng;Weilin Xia;Lian Yu;Bing Xu |
| 2 | CS2164 and Venetoclax Show Synergistic Antitumoral Activities in High Grade B-Cell Lymphomas With MYC and BCL2 Rearrangements | 期刊论文 | Delin Yuan;Genhong Li;Lian Yu;Yuelong Jiang;Yuanfei Shi;Qiulin Chen;Xiaomei Ma;Lan V. Pham;Ken H. Young;Manman Deng;Zhihong Fang;Bing Xu |
| 3 | Impairment of Vα24-Jα18+Vβ11+ natural killer T cells in adult acute lymphoblastic leukemia patients | 期刊论文 | Haijun Zhao;Zhifeng Li;Shiting Xie;Yiming Luo;Yong Zhou;Manman Deng;Hanyan Zeng;Jintao Zhao;Lian Yu;Bing Xu |
| 4 | Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway | 期刊论文 | Shi Yuan-Fei;Liu Long;He Ling-Li;Ye Jing;Lin Zhi-Juan;Yuan De-Lin;Deng Man-Man;Fang Zhi-Hong;Carter Bing Z.;Xu Bing |
| 5 | Simvastatin potentiates the cell-killing activity of imatinib in imatinib-resistant chronic myeloid leukemia cells mainly through PI3K/ AKT pathway attenuation and Myc downregulation | 期刊论文 | Lihong Ding;Qinwei Chen;Kai Chen;Yuelong Jiang;Genhong Li;Qiuling Chen;Dongyu Bai;Dehong Gao;Manman Deng;Haiping Zhang;Bing Xu |
| 6 | Disulfiram/copper shows potent cytotoxic effects on myelodysplastic syndromes via inducing Bip-mediated apoptosis and suppressing autophagy | 期刊论文 | Jie Zha;Silei Bi;Manman Deng;Kai Chen;Pengcheng Shi;Liying Feng;Jixiang He;Xuan Pu;Chengcen Guo;Haijun Zhao;Zhifeng Li;Yirong Jiang;Haihan Song;Bing Xu |
| 7 | 福建省科学技术奖 | 奖励 | 徐兵;方志鸿;李志峰;史鹏程;郭绪涛;李银;董慧娟 |
| 8 | Preclinical Evaluation of the HDAC Inhibitor Chidamide in Transformed Follicular Lymphoma | 期刊论文 | Mengya Zhong;Jinshui Tan;Guangchao Pan;Yuelong Jiang;Hui Zhou;Qian Lai;Qinwei Chen;Liyuan Fan;Manman Deng;Bing Xu;Jie Zha |
| 9 | CS2164 exerts an antitumor effect against human Non-Hodgkin's lymphomas in vitro and in vivo | 期刊论文 | Deng Manman;Shi Yuanfei;Chen Kai;Zhao Haijun;Wang Yan;Xie Siting;Zhao Jintao;Luo Yiming;Fang Zhihong;Fan Yaqun;Xu Bing |
| 10 | Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia | 期刊论文 | Deng Manman;Zha Jie;Jiang Zhiwu;Jia Xian;Shi Yuanfei;Li Peng;Chen Xiao Lei;Fang Zhihong;Du Zhiqiang;Xu Bing |
| 11 | T follicular helper cell-mediated IL-21 production suppresses FOXP3 expression of T follicular regulatory-like cells in diffuse large B cell lymphoma patients | 期刊论文 | Xiaomei Ma;Jie Zha;Jixiang He;Longtian Chen;Jianqing Huang;Weihao Wu;Pan Tian;Bao-Hua Qian;Lian Yu;Yirong Jiang;Bing Xu |
| 12 | Apatinib exhibits cytotoxicity toward leukemia cells by targeting VEGFR2-mediated prosurvival signaling and angiogenesis | 期刊论文 | Deng Manman;Zha Jie;Zhao Haijun;Jia Xian;Shi Yuanfei;Li Zhifeng;Fu Guo;Yu Lian;Fang Zhihong;Xu Bing |
| 13 | Apatinib exerts anti-tumor activity to non-Hodgkin lymphoma by inhibition of the Ras pathway | 期刊论文 | Yan Wang;Manman Deng;Qinwei Chen;Yin Li;Xutao Guo;Pengcheng Shi;Lingli He;Siting Xie;Lian Yu;Haiping Zhang;Bing Xu |
| 14 | CS2164 suppresses acute myeloid leukemia cell growth via inhibiting VEGFR2 signaling in preclinical models | 期刊论文 | Deng Manman;Zhao Haijun;Chen Qinwei;Zhao Jintao;Shi Yuanfei;Yu Lian;Fang Zhihong;Xu Bing |
| 15 | Preclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia | 期刊论文 | Chen Kai;Yang Qianying;Zha Jie;Deng Manman;Zhou Yong;Fu Guofeng;Bi Silei;Feng Liying;Xu-Monette Zijun Y.;Chen Xiao Lei;Fu Guo;Dai Yun;Young Ken H.;Xu Bing |
| 16 | Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage | 期刊论文 | Bi Silei;Chen Kai;Feng Liying;Fu Guofeng;Yang Qianying;Deng Manman;Zhao Haijun;Li Zhifeng;Yu Lian;Fang Zhihong;Xu Bing |
| 17 | Low-Dose Triptolide Enhanced Activity of Idarubicin Against Acute Myeloid Leukemia Stem-like Cells Via Inhibiting DNA Damage Repair Response | 期刊论文 | Shi Pengcheng;Zha Jie;Feng Juan;Jiang Zhiwu;Zhao Haijun;Deng Manman;Liao Naying;Li Peng;Jiang Yirong;Song Haihan;Xu Bing |
| 18 | IL-21-mediated expansion of Vγ9Vδ2 T cells is limited by the Tim-3 pathway | 期刊论文 | Kangni Wu;Haijun Zhao;Yanghui Xiu;Zhifeng Li;Jintao Zhao;Shiting Xie;Hanyan Zeng;Haiping Zhang;Lian Yu;Bing Xu |
| 19 | Clinical features and outcomes of 1845 patients with follicular lymphoma: a real-world multicenter experience in China | 期刊论文 | Zha Jie;Fan Liyuan;Yi Shuhua;Yu Haifeng;Zheng Zhong;Xu Wei;Deng Manman;Lin Zhijuan;Li Zhifeng;Ping Lingyan;He Xiaohua;Chen Feili;Xie Ying;Chen Biyun;Zhang Huilai;Wang Li;Ding Kaiyang;Li Wenyu;Yang Haiyan;Zhao Weili;Qiu Lugui;Li Zhiming;Song Yuqin;Xu Bing |
| 20 | Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo | 期刊论文 | Shi Yuanfei;Zhao Haijun;Ye Jing;Li Zhifeng;Deng Manman;Zha Jie;Zhou Yong;Zeng Hanyan;Lin Yun;Pu Xuan;Guo Chengcen;Song Haihan;Qiu Yi;Xu Bing |
| 21 | The prognostic impact of long noncoding RNA HOTAIR in leukemia and lymphoma: a meta-analysis | 期刊论文 | Yun Lin;Zhihong Fang;Zhijuan Lin;Zhifeng Li;Jintao Zhao;Yiming Luo;Bing Xu |
| 22 | 厦门市科学技术进步奖 | 奖励 | 徐兵;方志鸿;史鹏程;郭绪涛;李银;董慧娟;李志峰;周勇 |
| 23 | BCL11A and MDR1 expressions have prognostic impact in patients with acute myeloid leukemia treated with chemotherapy | 期刊论文 | Guo Xutao;Shi PengCheng;Li Yin;Dong Huijuan;Wang Yan;Zheng Haiqing;Xu Bing |
| 24 | Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway | 期刊论文 | Yang Qianying;Chen Kai;Zhang Leisi;Feng Liying;Fu Guofeng;Jiang Shan;Bi Silei;Lin Chunjie;Zhou Yong;Zhao Haijun;Chen Xiao Lei;Fu Guo;Xu Bing |
| 25 | Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair | 期刊论文 | Ye Jing;Zha Jie;Shi Yuanfei;Li Yin;Yuan Delin;Chen Qinwei;Lin Fusheng;Fang Zhihong;Yu Yong;Dai Yun;Xu Bing |
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