低浓度雷公藤甲素通过干扰DNA损伤修复机制增强去甲氧柔红霉素对AML 干细胞杀伤作用的研究

81570156
2015
H0809.白血病
徐兵
面上项目
教授
厦门大学
60万元
DNA修复;低浓度雷公藤甲素;DNA损伤;急性髓系白血病干细胞;去甲氧柔红霉素（IDA）
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption 期刊论文 Haijun Zhao;Pengcheng Shi;Manman Deng;Zhiwu Jiang;Yin Li;Vinodh Kannappa;Weiguang Wang;Peng Li;Bing Xu
2 Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway 期刊论文 Yang Qianying;Chen Kai;Zhang Leisi;Feng Liying;Fu Guofeng;Jiang Shan;Bi Silei;Lin Chunjie;Zhou Yong;Zhao Haijun;Chen Xiao Lei;Fu Guo;Xu Bing
3 Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair 期刊论文 Ye Jing;Zha Jie;Shi Yuanfei;Li Yin;Yuan Delin;Chen Qinwei;Lin Fusheng;Fang Zhihong;Yu Yong;Dai Yun;Xu Bing
4 CS2164 exerts an antitumor effect against human Non-Hodgkin's lymphomas in vitro and in vivo 期刊论文 Deng Manman;Shi Yuanfei;Chen Kai;Zhao Haijun;Wang Yan;Xie Siting;Zhao Jintao;Luo Yiming;Fang Zhihong;Fan Yaqun;Xu Bing
5 Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia 期刊论文 Deng Manman;Zha Jie;Jiang Zhiwu;Jia Xian;Shi Yuanfei;Li Peng;Chen Xiao Lei;Fang Zhihong;Du Zhiqiang;Xu Bing
6 Apatinib exerts anti-tumor activity to non-Hodgkin lymphoma by inhibition of the Ras pathway 期刊论文 Wang Y;Deng M;Chen Q;Li Y;Guo X;Shi P;He L;Xie S;Yu L;Zhang H;Xu B
7 CS2164 suppresses acute myeloid leukemia cell growth via inhibiting VEGFR2 signaling in preclinical models 期刊论文 Deng Manman;Zhao Haijun;Chen Qinwei;Zhao Jintao;Shi Yuanfei;Yu Lian;Fang Zhihong;Xu Bing
8 The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells 期刊论文 Zhang Leisi;Zhou Yong;Chen Kai;Shi Pengcheng;Li Yin;Deng Manman;Jiang Zhiwu;Wang Xiangmeng;Li Peng;Xu Bing
9 Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells 期刊论文 Li Y;Wang Y;Zhou Y;Li J;Chen K;Zhang L;Deng M;Deng S;Li P;Xu B
10 Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage 期刊论文 Bi Silei;Chen Kai;Feng Liying;Fu Guofeng;Yang Qianying;Deng Manman;Zhao Haijun;Li Zhifeng;Yu Lian;Fang Zhihong;Xu Bing
11 Co-operation of ABT-199 and gemcitabine in impeding DNA damage repair and inducing cell apoptosis for synergistic therapy of T-cell acute lymphoblastic leukemia 期刊论文 Zhu Xiufeng;Zhao Haijun;Bi Silei;Deng Manman;Zhou Yong;Yu Lian;Fang Zhihong;Xu Bing
12 Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2 期刊论文 Xu B;Wang S;Li R;Chen K;He L;Deng M;Kannappan V;Zha J;Dong H;Wang W
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