肿瘤免疫微环境STING靶向放射性分子探针构建与显像研究
91959122
2019
H2706.分子影像
张现忠
重大研究计划
教授
厦门大学
80万元
肿瘤免疫微环境;放射性标记;核医学显像;干扰素基因刺激蛋白;分子影像探针
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Synthesis of 18F-radiolabeled organophosphine fluorides for thiol-chemoselective peptide conjugation | 期刊论文 | huanglan zhuang;Zhide Guo;Rongqiang Zhuang;Xianzhong Zhang |
| 2 | MicroPET imaging of bacterial infection with nitroreductase-specific responsive 18F-labelled nitrogen mustard analogues | 期刊论文 | Lumei Huang;Jianyang Fang;Shouqiang Hong;Huanhuan Liu;Haotian Zhu;Lixia Feng;Rongqiang Zhuang;Xilin Zhao;Zhide Guo;Xianzhong Zhang |
| 3 | Synergism of 64Cu-Labeled RGD with Anti-PD-L1 Immunotherapy for the Long-Acting Antitumor Effect | 期刊论文 | Xuejun Wen;Xinying Zeng;Jia Liu;Yiren Zhang;Changrong Shi;Xiaoming Wu;Rongqiang Zhuang;Xiaoyuan Chen;Xianzhong Zhang;Zhide Guo |
| 4 | A novel 18F-labeled agonist for PET imaging of stimulator of interferon gene expression in tumor-bearing mice | 期刊论文 | Fang J;Feng L;Meng L;Wang X;Liu H;Huang L;Zhang D;Li J;Zhuang R;Guo Z;Zhang X |
| 5 | Optimum Combination of Radiopharmaceuticals‐Based Targeting‐Triggering‐Therapy Effect and PD‐L1 Blockade Immunotherapy | 期刊论文 | Xuejun Wen;Xinying Zeng;Changrong Shi;Jia Liu;Yiren Zhang;Mengqi Shi;Jingchao Li;Haojun Chen;Rongqiang Zhuang;Xiaoyuan Chen;Xianzhong Zhang;Zhide Guo |
| 6 | 68Ga-Labeled Maleimide for Blood Pool and Lymph PET Imaging through Covalent Bonding to Serum Albumin In Vivo | 期刊论文 | Lixia Feng;Jianyang Fang;Xinying Zeng;Huanhuan Liu;Jingru Zhang;Lumei Huang;Zhide Guo;Rongqiang Zhuang;Xianzhong Zhang |
| 7 | Preclinical and exploratory human studies of novel 68Ga-labeled D-peptide antagonist for PET imaging of TIGIT expression in cancers | 期刊论文 | Xiaobo Wang;Ming Zhou;Bei Chen;Huanhuan Liu;Jianyang Fang;Shijun Xiang;Shuo Hu;Xianzhong Zhang |
| 8 | Radioiodinated 4-(p-Iodophenyl) Butanoic Acid-Modified Estradiol Derivative for ER Targeting SPECT Imaging | 期刊论文 | Duo Xu;Xiaoru Lin;Xinying Zeng;Xuejun Wen;Jingchao Li;Yesen Li;Jinxiong Huang;Xiaoyuan Chen;Zhide Guo;Xianzhong Zhang |
| 9 | Preclinical and first-in-human evaluation of 18F-labeled D-peptide antagonist for PD-L1 status imaging with PET | 期刊论文 | Ming Zhou;Xiaobo Wang;Bei Chen;Shijun Xiang;Wanqian Rao;Zhe Zhang;Huanhuan Liu;Jianyang Fang;Xiaoqin Yin;Pengbo Deng;Xianzhong Zhang;Shuo Hu |
| 10 | Radioiodinated estradiol dimer for estrogen receptor targeted breast cancer imaging | 期刊论文 | Duo Xu;Chenyu Peng;Fei Gao;Zhide Guo;Rongqiang Zhuang;Xinhui Su;Xianzhong Zhang |
| 11 | Ligand Engineering of Titanium-Oxo Nanoclusters for Cerenkov Radiation-Reinforced Photo/Chemodynamic Tumor Therapy | 期刊论文 | Jingchao Li;Shuqi Dai;Ruixue Qin;Changrong Shi;Jiang Ming;Xinying Zeng;Xuejun Wen;Rongqiang Zhuang;Xiaoyuan Chen;Zhide Guo;Xianzhong Zhang |
| 12 | PD-L1-Targeted Radionuclide Therapy Combined with αPD-L1 Antibody Immunotherapy Synergistically Improves the Antitumor Effect | 期刊论文 | Xuejun Wen;Xinying Zeng;Xingxing Cheng;Xinying Zeng;Jia Liu;Yiren Zhang;Yesen Li;Haojun Chen;Jinxiong Huang;Zhide Guo;Xiaoyuan Chen;Xianzhong Zhang |
| 13 | 一种干扰素刺激蛋白靶向化合物、其标记物、及它们的制备方法与应用 | 专利 | 张现忠;方建阳;郭志德;封丽霞 |
| 14 | A radioiodinated FR-β-targeted tracer with improved pharmacokinetics through modification with an albumin binder for imaging of macrophages in AS and NAFL | 期刊论文 | Xuejun Wen;Changrong Shi;Liu Yang;Xinying Zeng;Xiaoru Lin;Jinxiong Huang;Yesen Li;Rongqiang Zhuang;Haibo Zhu;Zhide Guo;Xianzhong Zhang |
| 15 | A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect | 期刊论文 | Xuejun Wen;Changrong Shi;Xinying Zeng;Liang Zhao;Lanlin Yao;Zhida Liu;Lixia Feng;Deliang Zhang;Jinxiong Huang;Yesen Li;Qin Lin;Haojun Chen;Rongqiang Zhuang;Xiaoyuan Chen;Xianzhong Zhang;Zhide Guo |
| 16 | Rational Design and Pharmacomodulation of Protein-Binding Theranostic Radioligands for Targeting the Fibroblast Activation Protein | 期刊论文 | Lingxin Meng;Jianyang Fang;Liang Zhao;Tingting Wang;Pu Yuan;Zuoquan Zhao;Rongqiang Zhuang;Qin Lin;Haojun Chen;Xiaoyuan Chen;Xianzhong Zhang;Zhide Guo |
| 17 | Immuno-SPECT/PET imaging with radioiodinated anti-PD-L1 antibody to evaluate PD-L1 expression in immune-competent murine models and PDX model of lung adenocarcinoma | 期刊论文 | Xuejun Wen;Changrong Shi;Liang Zhao;Lanlin Yao;Duo Xu;Xiaoru Lin;Xinhui Su;Ting Liu;Rongqiang Zhuang;Qin Lin;Haojun Chen;Zhide Guo;Xianzhong Zhang |
| 18 | Development of 18F-labeled agonist for imaging STING in the tumor microenvironment | 会议论文 | Liu H;Li J;Fang J;Feng L;Yang H;Li J;Zhuang R;Guo Z;Zhang X |
| 19 | Development of 18F-labeled tracer for noninvasive PET imaging of the STING expression in tumor microenvironment | 会议论文 | Fang J;Feng L;Meng L;Guo Z;Zhang X |
| 20 | Noninvasive imaging of STING expression in tumor microenvironment using radioiodinated small molecule | 会议论文 | Fang J;Guo Z;Zhang X;Lin X |
| 21 | Development and Preclinical Evaluation of Radiolabeled Covalent G12C-Specific Inhibitors for Direct Imaging of the Oncogenic KRAS Mutant | 期刊论文 | Zhe Zhang;Xiaobo Wang;Jiajun Ye;Huanhuan Liu;Jianyang Fang;Mingru Zhang;Yesen Li;Jinxiong Huang;Deliang Zhang;Jing Wang;Xianzhong Zhang |
| 22 | Radioiodinated Ethinylestradiol Derivatives for Estrogen Receptor Targeting Breast Cancer Imaging | 期刊论文 | Huanhuan Liu;Xiaoru Lin;Duo Xu;Jingchao Li;Jianyang Fang;Jindian Li;Lingxin Meng;Xinying Zeng;Yesen Li;Jinxiong Huang;Zhide Guo;Xianzhong Zhang |
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