多聚化抗原诱导高效体液免疫应答的机制研究
31730029
2017
C0808.疫苗、抗体与免疫干预
夏宁邵
重点项目
教授
厦门大学
250万元
免疫效果;作用机制;重组抗原;疫苗效应;体液免疫反应
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Themis is indispensable for IL-2 and IL-15 signaling in T cells | 期刊论文 | Yongchao Liu;Yu Cong;Yujia Niu;Yin Yuan;Fancheng Tan;Qian Lai;Yanyan Hu;Bowen Hou;Jian Li;Chunjie Lin;Haiping Zheng;Junchen Dong;Jian Tang;Qinwei Chen;Joanna Brzostek;Xueqin Zhang;Xiao Lei Chen;Hong-Rui Wang;Nicholas R. J. Gascoigne;Bing Xu;Shu-Hai Lin;Guo Fu |
| 2 | Liver chimeric mice with tupaia hepatocyte transplantation as an animal model for hepatitis B virus infection and antiviral therapy | 期刊论文 | Lunzhi Yuan;Yao Chen;Xuan Liu;Yali Zhang;Ming Zhou;Kun Wu;Quan Yuan;Tong Cheng;Ningshao Xia |
| 3 | Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens | 期刊论文 | Luo Yong;Lin Chaolong;Zou Yidi;Ju Fei;Ren Wenfeng;Lin Yanhua;Wang Yale;Huang Xiaoxuan;Liu Huiling;Yu Zeng;Liu Pingguo;Tan Guowei;Yuan Quan;Zhang Jun;Huang Chenghao;Xia Ningshao |
| 4 | A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice | 期刊论文 | Zhang Tian-Ying;Guo Xue-Ran;Wu Yang-Tao;Kang Xiao-Zhen;Zheng Qing-Bing;Qi Ruo-Yao;Chen Bin-Bing;Lan Ying;Wei Min;Wang Shao-Juan;Xiong Hua-Long;Cao Jia-Li;Zhang Bao-Hui;Qiao Xiao-Yang;Huang Xiao-Fen;Wang Ying-Bin;Fang Mu-Jin;Zhang Ya-Li;Cheng Tong;Chen Yi-Xin;Zhao Qin-Jian;Li Shao-Wei;Ge Sheng-Xiang;Chen Pei-Jer;Zhang Jun;Yuan Quan;Xia Ning-shao |
| 5 | SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates | 期刊论文 | Li Tingting;Zheng Qingbing;Yu Hai;Wu Dinghui;Xue Wenhui;Xiong Hualong;Huang Xiaofen;Nie Meifeng;Yue Mingxi;Rong Rui;Zhang Sibo;Zhang Yuyun;Wu Yangtao;Wang Shaojuan;Zha Zhenghui;Chen Tingting;Deng Tingting;Wang Yingbin;Zhang Tianying;Chen Yixin;Yuan Quan;Zhao Qinjian;Zhang Jun;Gu Ying;Li Shaowei;Xia Ningshao |
| 6 | 含有利赛磷酸锌铝的佐剂及其应用 | 专利 | 赵勤俭;黄小芬;聂梅凤;张志刚;袁权;张天英;李少伟;夏宁邵 |
| 7 | A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters | 期刊论文 | Wu Yangtao;Huang Xiaofen;Yuan Lunzhi;Wang Shaojuan;Zhang Yali;Xiong Hualong;Chen Rirong;Ma Jian;Qi Ruoyao;Nie Meifeng;Xu Jingjing;Zhang Zhigang;Chen Liqiang;Wei Min;Zhou Ming;Cai Minping;Shi Yang;Zhang Liang;Yu Huan;Hong Junping;Wang Zikang;Hong Yunda;Yue Mingxi;Li Zonglin;Chen Dabing;Zheng Qingbing;Li Shaowei;Chen Yixin;Cheng Tong;Zhang Jun;Zhang Tianying;Zhu Huachen;Zhao Qinjian;Yuan Quan... |
| 8 | Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection | 期刊论文 | Xinlin Liu;Jie Chen;Zhiping Wang;Daning Wang;Maozhou He;Ciying Qian;Shuo Song;Xin Chi;Zhibo Kong;Qingbing Zheng;Yingbin Wang;Hai Yu;Qinjian Zhao;Jun Zhang;Shaowei Li;Ying Gu;Ningshao Xia |
| 9 | The Optimal Concentration of Formaldehyde is Key to Stabilizing the Pre-Fusion Conformation of Respiratory Syncytial Virus Fusion Protein | 期刊论文 | Wei Zhang;Lu-Jing Zhang;Lu-Ting Zhan;Min Zhao;Guang-Hua Wu;Jun-Yu Si;Li Chen;Xue Lin;Yong-Peng Sun;Min Lin;Chao Yu;Mu-Jin Fang;Ying-Bin Wang;Zi-Zheng Zheng;Ning-Shao Xia |
| 10 | Prophylactic Hepatitis E Vaccines: Antigenic Analysis and Serological Evaluation | 期刊论文 | Yike Li;Xiaofen Huang;Zhigang Zhang;Shaowei Li;Jun Zhang;Ningshao Xia;Qinjian Zhao |
| 11 | Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans | 期刊论文 | Gui-Ping Wen;Linling He;Zi-Min Tang;Si-Ling Wang;Xu Zhang;Yuan-Zhi Chen;Xiaohe Lin;Chang Liu;Jia-Xin Chen;Dong Ying;Zi-Hao Chen;Ying-Bin Wang;Wen-Xin Luo;Shou-Jie Huang;Shao-Wei Li;Jun Zhang;Zi-Zheng Zheng;Jiang Zhu;Ning-Shao Xia |
| 12 | Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles | 期刊论文 | Daning Wang;Xinlin Liu;Minxi Wei;Ciying Qian;Shuo Song;Jie Chen;Zhiping Wang;Qin Xu;Yurou Yang;Maozhou He;Xin Chi;Shiwen Huang;Tingting Li;Zhibo Kong;Qingbing Zheng;Hai Yu;Yingbin Wang;Qinjian Zhao;Jun Zhang;Ningshao Xia;Ying Gu;Shaowei Li |
| 13 | Demonstration of real-time and accelerated stability of hepatitis E vaccine with a combination of different physicochemical and immunochemical methods | 期刊论文 | Xiaochen Yin;Xin Wang;Zhigang Zhang;Yufang Li;Zhijie Lin;Huirong Pan;Ying Gu;Shaowei Li;Jun Zhang;Ningshao Xia;Qinjian Zhao |
| 14 | Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine | 期刊论文 | Yangtao Wu;Shaojuan Wang;Yali Zhang;Lunzhi Yuan;Qingbing Zheng;Min Wei;Yang Shi;Zikang Wang;Jian Ma;Kai Wang;Meifeng Nie;Jin Xiao;Zehong Huang;Peiwen Chen;Huilin Guo;Miaolin Lan;Jingjing Xu;Wangheng Hou;Yunda Hong;Dabing Chen;Hui Sun;Hualong Xiong;Ming Zhou;Che Liu;Wenjie Guo;Huiyu Guo;Jiahua Gao;Zhixiong Li;Haitao Zhang;Xinrui Wang;Shaowei Li;Tong Cheng;Qinjian Zhao;Yixin Chen;Ting Wu... |
| 15 | Neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2 | 期刊论文 | Hualong Xiong;Haiyan Sun;Siling Wang;Lunzhi Yuan;Liyuan Liu;Yuhe Zhu;Jinlei Zhang;Yang Huang;Ruoyao Qi;Yao Jiang;Jian Ma;Ming Zhou;Yue Ma;Rao Fu;Siping Yan;Mingxi Yue;Yangtao Wu;Min Wei;Yizhen Wang;Tingting Li;Yingbin Wang;Zizheng Zheng;Hai Yu;Tong Cheng;Shaowei Li;Quan Yuan;Jun Zhang;Yi Guan;Qingbing Zheng;Tianying Zhang;Ningshao Xia |
| 16 | IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella | 期刊论文 | Qiubin Lin;Li Rong;Xian Jia;Renhao Li;Bin Yu;Jingchu Hu;Xiao Luo;S. R. Badea;Chen Xu;Guofeng Fu;Kejiong Lai;Ming-chun Lee;Baozhong Zhang;Huarui Gong;Nan Zhou;Xiao Lei Chen;Shu-hai Lin;Guo Fu;Jian-Dong Huang |
| 17 | 利塞膦酸锌微纳米佐剂的制备及作为疫苗佐剂的用途 | 专利 | 赵勤俭;黄小芬;李宜珂;聂梅凤;陈思伊;夏宁邵 |
| 18 | Safety and immunogenicity of a live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine in adults: randomised, double-blind, placebo-controlled, phase 1 and 2 trials | 期刊论文 | Fengcai Zhu;Chunlan Zhuang;Kai Chu;Liang Zhang;Hui Zhao;Shoujie Huang;Yingying Su;Hongyan Lin;Changlin Yang;Hanmin Jiang;Xia Zang;Donglin Liu;Hongxing Pan;Yuemei Hu;Xiaohui Liu;Qi Chen;Qiaoqiao Song;Jiali Quan;Zehong Huang;Guohua Zhong;Junyu Chen;Jinle Han;Hong Sun;Lunbiao Cui;Jingxin Li;Yixin Chen;Tianying Zhang;Xiangzhong Ye;Changgui Li;Ting Wu;Jun Zhang;Ning-Shao Xia |
| 19 | New discovery of high-affinity SARS-CoV-2 spike S2 protein binding peptide selected by PhIP-Seq | 期刊论文 | Mengyuan Chen;Shuizhen He;Hualong Xiong;Dongxu Zhang;Shaojuan Wang;Wangheng Hou;Xiaomei Zhu;Jin Wang;Yang Huang;Congming Hong;Yubin Wu;Ruoyao Qi;Tianying Zhang;Quan Yuan;Tingdong Li;Yixin Chen;Shiyin Zhang;Shengxiang Ge;Jun Zhang;Ningshao Xia |
| 20 | Profile of clinical characteristics and serologic markers of sporadic hepatitis E in a community cohort study | 期刊论文 | Zi-Min Tang;Gui-Ping Wen;Dong Ying;Si-Ling Wang;Chang Liu;Wei-Kun Tian;Ying-Bin Wang;Mu-Jin Fang;Yu-Lin Zhou;Yun-Sheng Ge;Ting Wu;Jun Zhang;Shou-Jie Huang;Zi-Zheng Zheng;Ning-Shao Xia |
| 21 | Simultaneous in situ visualization and quantitation of dual antigens adsorbed on adjuvants using high content analysis | 期刊论文 | Zhigang Zhang;Tianying Zhang;Lu Cao;Xin Wang;Jiali Cao;Xiaofen Huang;Yashuang Cai;Zhijie Lin;Huirong Pan;Quan Yuan;Mujin Fang;Shaowei Li;Jun Zhang;Ningshao Xia;Qinjian Zhao |
| 22 | Multifaceted characterization of recombinant protein-based vaccines: An immunochemical toolbox for epitope-specific analyses of the hepatitis E vaccine | 期刊论文 | Wang Xin;Li Min;Lin Zhijie;Pan Huirong;Tang Zimin;Zheng Zizheng;Li Shaowei;Zhang Jun;Xia Ningshao;Zhao Qinjian |
| 23 | Intermittent abortive reactivation of Epstein-Barr virus during the progression of nasopharyngeal cancer as indicated by elevated antibody levels | 期刊论文 | Guo Xiaoyi;Li Tingdong;Li Fugui;Xu Yarui;Wang Han;Cheng Weimin;Tang Jiabao;Zhou Guoliang;Chen Honglin;Ng Munhon;Ji Mingfang;Ge Shengxiang;Xia Ningshao |
| 24 | Altered antigenicity and immunogenicity of human papillomavirus virus-like particles in the presence of thimerosal | 期刊论文 | Siyi Chen;Xiaofen Huang;Yike Li;Xin Wang;Huirong Pan;Zhijie Lin;Qingbing Zheng;Shaowei Li;Jun Zhang;Ningshao Xia;Qinjian Zhao |
| 25 | POLYPEPTIDE CARRIER FOR PRESENTING TARGET POLYPEPTIDE AND USES THEREOF | 专利 | 张天英;袁权;郭雪染;张莹;赵勤俭;张军;夏宁邵 |
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