新生期再编程介导慢性内脏痛的表观调控机制研究

81230024
2012
H0903.感觉障碍、疼痛与镇痛
徐广银
重点项目
教授
苏州大学
280万元
新生期再编程;下丘脑-垂体-肾上腺轴;肠易激综合症;慢性内脏痛;表观遗传学
2013-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种A317491药物纳米粒子及其应用、制剂 专利 徐广银;周友浪;蒋国勤;张弘弘;胡淑芬;刘春风
2 Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion. 期刊论文 Zhou Yuan;Li Rong-Ji;Li Meng;Liu Xuelian;Zhu Hong-Yan;Ju Zhong;Miao Xiuhua;Xu Guang-Yin
3 慢性内脏痛的病理机制研究和临床治疗新进展 期刊论文 张弘弘;孙艳;徐广银
4 Sensitization of sodium channels by cystathionine beta-synthetase activation in colon sensory neurons in adult rats with neonatal maternal deprivation 期刊论文 Hu Shufen;Xu Weiyuan;Miao Xiuhua;Gao Yanping;Zhu Liyan;Zhou Youlang;Xiao Ying;Xu Guang-Yin
5 Neonatal colonic inflammation sensitizes voltage-gated Na+ channels via upregulation of cystathionine beta-synthetase expression in rat primary sensory neurons 期刊论文 Qu Ruobing;Tao Jingde;Wang Yongmeng;Zhou Youlang;Wu Geping;Xiao Ying;Hu Chuang-Ying;Jiang Xinghong;Xu Guang-Yin
6 Colonic hypersensitivity and sensitization of voltage-gated sodium channels in primary sensory neurons in rats with diabetes. 期刊论文 Hu Ji;Song Zhen-Yuan;Zhang Hong-Hong;Qin Xin;Hu Shufen;Jiang Xinghong;Xu Guang-Yin
7 Promoted Interaction of Nuclear Factor-kappaB With Demethylated Purinergic P2X3 Receptor Gene Contributes to Neuropathic Pain in Rats With Diabetes. 期刊论文 Zhang Hong-Hong;Hu Ji;Zhou You-Lang;Qin Xin;Song Zhen-Yuan;Yang Pan-Pan;Hu Shufen;Jiang Xinghong;Xu Guang-Yin
8 Promoted Interaction of Nuclear Factor-kappa B with Demethylated Cystathionine-beta-Synthetase Gene Contributes to Gastric Hypersensitivity in Diabetic Rats 期刊论文 Zhang Hong-Hong;Hu Ji;Zhou You-Lang;Hu Shufen;Wang Yong-Meng;Chen Wei;Xiao Ying;Huang Li-Yen Mae;Jiang Xinghong;Xu Guang-Yin
9 Adrenergic beta2-receptors mediates visceral hypersensitivity induced by heterotypic intermittent stress in rats. 期刊论文 Zhang Chunhua;Rui Yun-Yun;Zhou Yuan-Yuan;Ju Zhong;Zhang Hong-Hong;Hu Chuang-Ying;Xiao Ying;Xu Guang-Yin
10 Upregulation of Cystathionine beta-Synthetase Expression Contributes to Visceral Hyperalgesia Induced by Heterotypic Intermittent Stress in Rats 期刊论文 Wang Yongmeng;Qu Ruobing;Hu Shufen;Xiao Ying;Jiang Xinghong;Xu Guang-Yin
11 Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine beta-Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity 期刊论文 Zhao Liting;Xiao Ying;Weng Rui-Xia;Liu Xuelian;Zhang Ping-An;Hu Chuang-Ying;Yu Shan P.;Xu Guang-Yin
12 Hyperexcitability and sensitization of sodium channels of dorsal root ganglion neurons in a rat model of lumber disc herniation. 期刊论文 Yan Jun;Zou Kang;Liu Xiaofeng;Hu Shufen;Wang Qianliang;Miao Xiuhua;Zhu Hong-Yan;Zhou Youlang;Xu Guang-Yin
13 Electroacupuncture Suppresses Mechanical Allodynia and Nuclear Factor Kappa B Signaling in Streptozotocin-Induced Diabetic Rats 期刊论文 Shi Lei;Zhang Hong-Hong;Xiao Ying;Hu Ji;Xu Guang-Yin
14 Phosphorylation of NR2B NMDA subunits by protein kinase C in arcuate nucleus contributes to inflammatory pain in rats. 期刊论文 Bu Fan;Tian Huiyu;Gong Shan;Zhu Qi;Xu Guang-Yin;Tao Jin;Jiang Xinghong
15 Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root GanQlion Neurons Innervating the Rat Stomach 期刊论文 Li Meng;Xue Lu;Zhu Hong-Yan;Wang Hongjun;Xu Xue;Zhang Ping-An;Wu Geping;Xu Guang-Yin
16 TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation. 期刊论文 Xiao Ying;Chen Xiaoqi;Zhang Ping-An;Xu Qiya;Zheng Hang;Xu Guang-Yin
17 TLR4 upregulates CBS expression through NF-kappaB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity. 期刊论文 Yuan Bo;Tang Wei-Hong;Lu Li-Juan;Zhou Yuan;Zhu Hong-Yan;Zhou You-Lang;Zhang Hong-Hong;Hu Chuang-Ying;Xu Guang-Yin
18 Acute effects of TGFbeta1 on neuronal excitability and involvement in the pain of rats with chronic pancreatitis. 期刊论文 Zhang Xiaoyu;Zheng Hang;Zhu Hong-Yan;Hu Shufen;Wang Shusheng;Jiang Xinghong;Xu Guang-Yin
19 Upregulation of cystathionine beta-synthetase in the arcuate nucleus produces pain hypersensitivity via PKC upregulation and GluN2B phosphorylation in rats with chronic pancreatitis. 期刊论文 Zheng Hang;Zhu Hong-Yan;Zhang Xiao-Yu;Wang Meng;Xiao Ying;Xu Guang-Yin;Jiang Xing-Hong
20 alpha-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats 期刊论文 Sun Yan;Yang Pan-Pan;Song Zhen-Yuan;Feng Yu;Hu Duan-Min;Hu Ji;Xu Guang-Yin;Zhang Hong-Hong
21 Sensitization of P2X3 receptors by cystathionine beta-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation. 期刊论文 Wang Qianliang;Zhu Hongyan;Zou Kang;Yuan Bo;Zhou You-Lang;Jiang Xinghong;Yan Jun;Xu Guang-Yin
22 Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine beta-synthetase in a rat model of visceral hypersensitivity. 期刊论文 Zhu Liyan;Zhao Liting;Qu Ruobing;Zhu Hong-Yan;Wang Yongmeng;Jiang Xinghong;Xu Guang-Yin
23 一种在布洛芬缓释纳米微球及其制备方法和应用 专利 徐广银;周友浪;胡淑芬
24 Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats 期刊论文 Hu Ji;Qin Xin;Song Zhen-Yuan;Yang Pan-Pan;Feng Yu;Sun Qian;Xu Guang-Yin;Zhang Hong-Hong
25 Electroacupuncture attenuates visceral hypersensitivity and reverses upregulation of TRPV1 expression in adult rats with neonatal maternal deprivation 期刊论文 Zhu Hong-Yan;Hu Shufen;Miao Xiuhua;Xu Guang-Yin
26 Adrenergic signaling mediates mechanical hyperalgesia through activation of P2X3 receptors in primary sensory neurons of rats with chronic pancreatitis. 期刊论文 Wang Shusheng;Zhu Hong-Yan;Jin Yi;Zhou Youlang;Hu Shufen;Liu Tong;Jiang Xinghong;Xu Guang-Yin
27 Upregulation of CBS expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation 期刊论文 Li Lin;Xie Ruihua;Hu Shufen;Wang Yongmeng;Yu Tianzhu;Xiao Ying;Jiang Xinghong;Gu Jianguo;Hu Chuangying;Xu Guang-Yin
28 Upregulation of cystathionine-β-synthetase expression contributes to inflammatory pain in rat temporomandibular joint 期刊论文 Miao Xiuhua;Meng Xiaowen;Wu Geping;Ju Zhong;Zhang Hong-Hong;Hu Shufen;Xu Guang-Yin
29 Inhibition of cystathionine beta-synthetase suppresses sodium channel activities of dorsal root ganglion neurons of rats with lumbar disc herniation. 期刊论文 Yan Jun;Hu Shufen;Zou Kang;Xu Min;Wang Qianliang;Miao Xiuhua;Yu Shan Ping;Xu Guang-Yin
30 Up-regulation of CXCR4 expression contributes to persistent abdominal pain in rats with chronic pancreatitis 期刊论文 Zhu Hong-Yan;Liu Xuelian;Miao Xiuhua;Li Di;Wang Shusheng;Xu Guang-Yin
31 Neonatal maternal deprivation sensitizes voltage-gated sodium channel currents in colon-specific dorsal root ganglion neurons in rats 期刊论文 Hu Shufen;Xiao Ying;Zhu Liyan;Li Lin;Hu Chuang-Ying;Jiang Xinghong;Xu Guang-Yin
32 Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity. 期刊论文 Zhang Ping-An;Xu Qiya;Xue Lu;Zheng Hang;Yan Jun;Xiao Ying;Xu Guang-Yin
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