调控线粒体代谢和活性氧簇（ROS）生成对帕金森病小胶质细胞激活的影响

31871023
2018
C0901.分子与细胞神经生物学
王光辉
面上项目
教授
苏州大学
60万元
线粒体;炎症;小胶质细胞;帕金森病;活性氧簇
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 E3 ubiquitin ligase HRD1 modulates the circadian clock through regulation of BMAL1 stability 期刊论文 Guo Dongkai;Zhu Yao;Wang Hongfeng;Wang Guanghui;Wang Cheng;Ren Haigang
2 DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65 期刊论文 Lin Zixuan;Chen Chen;Yang Dongqin;Ding Jianqing;Wang Guanghui;Ren Haigang
3 alpha-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome 期刊论文 Wang Rui;Sun Hongyang;Ren Haigang;Wang Guanghui
4 Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Causes Neurotoxicity by Clathrin-Dependent Endocytosis. 期刊论文 Wang Rui;Xu Xingyun;Hao Zongbing;Zhang Shun;Wu Dan;Sun Hongyang;Mu Chenchen;Ren Haigang;Wang Guanghui
5 Association of Glial Activation and α-Synuclein Pathology in Parkinson's Disease 期刊论文 Rui Wang;Haigang Ren;Elena Kaznacheyeva;Xiaojun Lu;Guanghui Wang
6 帕唑帕尼在制备神经炎症抑制中的应用 专利 王光辉;孙宏洋
7 帕金森病非运动症状及机制研究 奖励 刘春风;王光辉;毛成洁;胡丽芳;王芬;杨亚萍;罗蔚锋;沈赟
8 Imbalance of Lysine Acetylation Contributes to the Pathogenesis of Parkinson's Disease 期刊论文 Wang Rui;Sun Hongyang;Wang Guanghui;Ren Haigang
9 Role of the C9ORF72 Gene in the Pathogenesis of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. 期刊论文 Hao Zongbing;Wang Rui;Ren Haigang;Wang Guanghui
10 帕金森病遗传与环境因素对小胶质细胞的激活及其机制(2021苏州市医学会医学科技奖一等奖) 奖励 王光辉;任海刚;郭东凯;王小玉;顾超;胡青松;王诚;王锐
11 Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration. 期刊论文 Zhang Shun;Wang Rui;Wang Guanghui
12 DJ-1 regulates tyrosine hydroxylase expression through CaMKKbeta/CaMKIV/CREB1 pathway in vitro and in vivo. 期刊论文 Xu Xingyun;Wang Rui;Hao Zongbing;Wang Guanghui;Mu Chenchen;Ding Jianqing;Sun Wanping;Ren Haigang
13 The Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson's Disease 期刊论文 Ren Haigang;Zhai Wanqing;Lu Xiaojun;Wang Guanghui
14 Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR 期刊论文 Hao Zongbing;Liu Liu;Tao Zhouteng;Wang Rui;Ren Haigang;Sun Hongyang;Lin Zixuan;Zhang Zhixiong;Mu Chenchen;Zhou Jiawei;Wang Guanghui
15 Local Circuits in the Cerebellum Interact with Biochemical Events 期刊论文 Hongyang Sun;Guanghui Wang
16 Dependence of PINK1 accumulation on mitochondrial redox system 期刊论文 Gao Feng;Zhang Yan;Hou Xiaoou;Tao Zhouteng;Ren Haigang;Wang Guanghui
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