肠-脑轴功能稳态失衡介导慢性内脏痛中枢敏化的机制研究

31730040
2017
C1105.整合生理学与整合生物学
徐广银
重点项目
教授
苏州大学
299万元
内脏痛;肠易激综合征;内稳态;中枢敏化;肠道菌群
2018-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 High-resolution 3D demonstration of regional heterogeneity in the glymphatic system 期刊论文 Xu-Zhong He;Xin Li;Zhen-Hua Li;Jing-Cai Meng;Rui-Ting Mao;Xue-Ke Zhang;Rong-Ting Zhang;Huai-Liang Huang;Qian Gui;Xu Guang-Yin;Linhui Wang
2 Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex 期刊论文 Xiao Ying;Xie Lei;Xu Qi-Ya;Chen Li;Chen Huan;Xu Guang-Yin;Zhang Ping-An
3 Neuroscience Bulletin编委杰出贡献奖 奖励 徐广银
4 MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis 期刊论文 Long Hanchun;Wu Rui;Liu Chunfeng;Xiong Feilong;Xu Zu;He Dian;Zhang Yifan;Shao Bing;Zhang Pingan;Xu Guang-Yin;Chu Lan
5 Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats 期刊论文 Xiao-Jun Cao;Rui Wu;He-Ya Qian;Xiang Chen;Hong-Yan Zhu;Xu Guang-Yin;Ye-Zi Sun;Ping-An Zhang
6 HDCA9及其抑制剂的新用途 专利 徐广银;张海龙;胡淑芬;吕梦丹;沈碧玉
7 一种大鼠灌流装置 专利 沈碧玉;徐广银;张平安;徐启亚;陈昊洋
8 Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia 期刊论文 Wu Rui;Zhang Pingan;Liu Xuelian;Zhou Yuan;Xu Meijie;Jiang Xinghong;Yan Jun;Xu Guang-Yin
9 P2X受体DNA去甲基化增强介导慢性疼痛 奖励 徐广银;周友浪;胡淑芬;张弘弘;胡吉;王前亮;沈碧玉;蒋星红
10 Folic acid attenuates chronic visceral pain by reducing Clostridiales abundance and hydrogen sulfide production 期刊论文 Rui-Xia Weng;Ying-Xue Wei;Yong-Chang Li;Xue Xu;Jian-Bo Zhuang;Xu Guang-Yin;Rui Li
11 Downregulation of glucose-6-phosphate dehydrogenase contributes to diabetic neuropathic pain through upregulation of toll-like receptor 4 in rats 期刊论文 Sun Qian;Zhang Bing Yu;Zhang Pin An;Hu Ji;Zhang Hong Hong;Xu Guang Yin
12 Sensitization of P2X3 receptors in insular cortex contributes to visceral pain of adult rats with neonatal maternal deprivation 期刊论文 Zhang Ping-An;Zhu Hong-Yan;Xu Qi-Ya;Du Wan-Jie;Hu Shufen;Xu Guang-Yin
13 一种用于动物实验的胃部球囊装置 专利 徐广银;张平安;张弘弘;胡淑芬;沈碧玉
14 一种折叠式大鼠游泳用多功能盆 专利 沈碧玉;徐广银;胡淑芬;许宇成;宋绍永;陈昊洋
15 Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats 期刊论文 Li Yong-Chang;Tian Yuan-Qing;Wu Yan-Yan;Xu Yu-Cheng;Zhang Ping-An;Sha Jie;Xu Guang-Yin
16 Upregulation of lncRNA-NONRATT021203.2 in the dorsal root ganglion contributes to cancer-induced pain via CXCL9 in rats 期刊论文 Sun Rong-Mao;Wei Jinrong;Wang Shu-Sheng;Xu Guang-Yin;Jiang Guo-Qin
17 Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress 期刊论文 Yuan-Qing Tian;Jia-Hui Li;Yong-Chang Li;Yu-Cheng Xu;Ping-An Zhang;Qian Wang;Rui Li;Xu Guang-Yin
18 Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity 期刊论文 Du Wanjie;Hu Shufen;Li Xin;Zhang Pingan;Jiang Xinghong;Yu Shanping;Xu Guang-Yin
19 Prenatal maternal stress induces visceral hypersensitivity of adult rat offspring through activation of cystathionine-β-synthase signaling in primary sensory neurons 期刊论文 Hong-Jun Wang;Xue Xu;Rui-Hua Xie;Yun-Yun Rui;Ping-An Zhang;Xiao-Jue Zhu;Xu Guang-Yin
20 一种病理试验用活体白鼠艾灸固定架 专利 沈碧玉;徐广银;李惠玲;李永昌
21 一种用于小鼠颅内超微注射的给药装置 专利 胡淑芬;徐广银;位迎雪;李永昌;赵伟明;吕梦丹
22 DNA甲基化在糖尿病神经病变中的作用及机制研究 奖励 张弘弘;胡吉;徐广银;王猛猛;周友浪
23 A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain 期刊论文 Li Yong-Chang;Wang Qian;Li Mengge;Hu Shufen;Xu Guang-Yin
24 Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes 期刊论文 Zhang Ping-An;Sun Qian;Li Yong-Chang;Weng Rui-Xia;Wu Rui;Zhang Hong-Hong;Xu Guang-Yin
25 Adult Stress Promotes Purinergic Signaling to Induce Visceral Pain in Rats with Neonatal Maternal Deprivation 期刊论文 Hu Shufen;Sun Qian;Du Wanjie;Song Jian;Li Xin;Zhang Pingan;Xu Jitian;Xu Guang-Yin
26 miR-1306-3p directly activates P2X3Rs in primary sensory neurons to induce visceral pain in rats 期刊论文 Wu Yan-Yan;Wang Qian;Zhang Ping-An;Zhu Cheng;Xu Guang-Yin
27 Targeting spinal TRAF6 expression attenuates chronic visceral pain in adult rats with neonatal colonic inflammation 期刊论文 Weng Rui-Xia;Chen Wei;Tang Jia-Ni;Sun Qian;Li Meng;Xu Xue;Zhang Ping-An;Zhang Ying;Hu Chuang-Ying;Xu Guang-Yin
28 MiRNA-107 contributes to inflammatory pain by down-regulating GLT-1 expression in rat spinal dorsal horn 期刊论文 Zhang Ling;Wu Rui;Xu Mei-Jie;Sha Jie;Xu Guang-Yin;Wu Jian;Zhang Ping-An
29 Upregulation of spinal ASIC1 by miR-485 mediates enterodynia in adult offspring rats with prenatal maternal stress 期刊论文 Xu Xue;Li Yong-Chang;Wu Yan-Yan;Xu Yu-Cheng;Weng Rui-Xia;Wang Cai-Lin;Zhang Ping-An;Zhang Ying;Xu Guang-Yin
30 一种缓解肠易激综合征慢性内脏痛敏的寡脱氧核糖核苷酸 专利 徐广银;张平安;许雪;杜婉洁;许宇成;张冰玉
31 基于动物体通信的疼痛信号检测装置及其检测方法 专利 徐广银;沈碧玉;胡淑芬;张海龙;王健;孙倩;李永昌
32 一种CIA大鼠造模技术 专利 沈碧玉;徐广银;许宇成;陈昊洋;李惠玲;宋绍永;田原青
33 小鼠胃部扩张实验的球囊装置 专利 徐广银;张夫超;胡淑芬;徐启亚;武井来
34 Identification of a Glutamatergic Claustrum-Anterior Cingulate Cortex Circuit for Visceral Pain Processing. 期刊论文 Qi-Ya Xu;Hai-Long Zhang;Han Du;Yong-Chang Li;Fu-hai Ji;Rui Li;Xu Guang-Yin
35 Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation 期刊论文 Yan-Yan Wu;Hai-Long Zhang;Xiaomin Lu;Han Du;Yong-Chang Li;Ping-An Zhang;Xu Guang-Yin
36 Decreased MiR-485-5p Contributes to Inflammatory Pain Through Post-Transcriptional Upregulation of ASIC1 in Rat Dorsal Root Ganglion 期刊论文 Xu Meijie;Wu Rui;Zhang Ling;Zhu Hong-Yan;Xu Guang-Yin;Qian Wenxia;Zhang Ping-An
37 Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation 期刊论文 Xin Li;Yu-Cheng Xu;Yuan-Qin Tian;Ping-An Zhang;Shu-Fen Hu;Lin-Hui Wang;Xing-Hong Jiang;Xu Guang-Yin
38 神经科学 专著 徐广银
39 Epigenetic upregulation of acid-sensing ion channel 1 contributes to gastric hypersensitivity in adult offspring rats with prenatal maternal stress 期刊论文 Wang Hong-Jun;Xu Xue;Zhang Ping-An;Li Meng;Zhou You-Lang;Xu Yu-Cheng;Jiang Xing-Hong;Xu Guang-Yin
40 糖尿病神经病变的临床特征及神经分子机制研究 奖励 胡吉;张弘弘;徐广银;方晨;肖文全
41 一种病理实验用活体白鼠经颅直流电刺激固定的支架 专利 徐广银;徐启亚;张平安;胡淑芬;沈碧玉
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