【U1032604】三七止血/活血双向调节作用的生物效应物质基础及作用机理研究国家自然基金项目

三七止血/活血双向调节作用的生物效应物质基础及作用机理研究

项目批准号： U1032604

批准年份： 2010

学科分类： H3203.中药药效物质

项目负责人：王峥涛

资助类别：联合基金项目

负责人职称：教授

依托单位：上海中医药大学

资助金额： 160万元

关键词：皂苷类;三七;双向调节;止血/活血;三七素

起止时间： 2011-01-01到2014-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	Decichine enhances hemostasis of activated platelets via AMPA receptors	期刊论文	Huang LF\|Shi HL\|Gao B\|Wu H\|Yang L\|Wu XJ\|Wang ZT\|
2	Notoginsenoside Ft1 promotes angiogenesis via HIF-1 alpha mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways	期刊论文	Shen, Kaikai\|Ji, Lili\|Gong, Chenyuan\|Ma, Yibo\|Yang, Li\|Fan, Yi\|Hou, Maoqi\|Wang, Zhengtao\|
3	Platelet P2Y12 receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng.	期刊论文	Bo Gao\|Lingfang Huang\|Eryun Zhang\|Li Yang\|Xiaojun Wu\|Zhengtao Wang\|
4	Metabolic profiles of 20(S)-protopanaxadiol in rats after oral administration using ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry.	期刊论文	He CY\|Li J\|Wang RF\|Li ZY\|Bligh SWA\|Yang L\|Wang ZT\|
5	A Universal Quantitative 1H Nuclear Magnetic Resonance (qNMR) Method for Assessing the Purity of Dammarane-type Ginsenosides.	期刊论文	Li ZY\|Welbeck E\|Wang RF\|Liu Q\|Yang YB\|Chou GX\|Bi KS\|Wang ZT\|
6	Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway	期刊论文	Jingjing Zhang\|Wei Dou\|Eryun Zhang\|Aning Sun\|Zhengtao Wang\|
7	Chrysin Ameliorates Chemically Induced Colitis in the Mouse through Modulation of a PXR/NF-kappa B Signaling Pathway	期刊论文	Dou, Wei\|Zhang, Jingjing\|Zhang, Eryun\|Sun, Aning\|Ding, Lili\|Chou, Guixin\|Wang, Zhengtao\|Mani, Sridhar\|
8	Enzymatic transformation of vina-ginsenoside R7 to rare notoginsenoside ST-4 using a new recombinant glycoside hydrolase from Herpetosiphon aurantiacus	期刊论文	Wang RF\|Zheng MM\|Cao YD\|Li H\|Li CX\|Xu JH\|Wang ZT\|
9	Platelet P2Y12 receptor involved in the hemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng	期刊论文	Gao B\|Huang LF\|Liu HS\|Wu H\|Zhang EY\|Yang L\|Wu XJ\|Wang ZT\|
10	Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways.	期刊论文	Shen KK\|Ji LL\|Gong CY\|Ma YB\|Yang L\|Fan Y\|Hou MQ\|Wang ZT\|
11	Notoginsenoside R1 Attenuates Experimental Inflammatory Bowel Disease via Pregnane X Receptor Activation.	期刊论文	Ding LL\|Wang BC\|Ren GY\|Sun AN\|Deng C\|Wei XH\|Mani S\|Wang ZT\|Dou W\|
12	Identification of 20(S)-protopanaxatriol metabolites in rats by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance spectroscopy	期刊论文	Chunyong He\|Dandan Zhou\|Jia Li\|Han Han\|Li Yang\|Zhengtao Wang\|
13	血小板信号转导及相关抗血小板药物的研究进展	期刊论文	黄玲芳\|张二云\|高波\|吴晓俊\|王峥涛\|
14	p38 MAPK and ERK1/2 pathways are involved in the pro-apoptotic effect of notoginsenoside Ft1 on human neuroblastoma SH-SY5Y cells.	期刊论文	Gao B\|Shi HL\|Li X\|Qiu SP\|Wu H\|Zhang BB\|Wu XJ\|Wang ZT\|
15	Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries.	期刊论文	Shen KK\|Leung SWS\|Ji LL\|Huang Y\|Hou MQ\|Xu AM\|Wang ZT\|Vanhoutte PM\|
16	Critical role of c-Jun N-terminal kinase in regulating bFGF-induced angiogenesis in vitro	期刊论文	Shen Kaikai\|Sheng Yuchen\|Ji Lili\|Wang Zhengtao\|
17	Critical role of c-Jun N-terminal kinase in regulating bFGF-induced angiogenesis in vitro.	期刊论文	Shen KK\|Sheng YC\|Ji LL\|Wang ZT\|
18	Identification of 20 (S)-protopanaxatriol metabolites in rats by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance spectroscopy	期刊论文	He CY\|Zhou DD\|Yang L\|Li J\|Han H\|Ji G\|Wang ZT\|
19	c-Jun N-terminal kinase mediated VEGFR2 sustained phosphorylation is critical for VEGFA-induced angiogenesis in vitro and in vivo.	期刊论文	Shen KK\|Ji LL\|Lu B\|Wang ZT\|
20	Protective effect of naringenin against experimental colitis via suppression of TLR4/NF-κB signaling	期刊论文	Wei Dou\|Jingjing Zhang\|Aning Sun\|Eryun Zhang\|Lili Ding\|Guixin Chou\|Zhengtao Wang\|

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