化学修饰策略构建高稳定性抗菌肽polybia-CP衍生物及其抗真菌活性研究
81573265
2015
H3401.合成药物化学
王凯荣
面上项目
教授
兰州大学
25万元
抗菌肽;非天然氨基酸;酶解稳定性;抗真菌活性;化学修饰
2016-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Synthesis of Chiral α‑Trifluoromethylamines with 2,2,2-Trifluoroethylamine as a “Building Block” | 期刊论文 | Xiaoyuan Li;Jinhuan Su;Zhourujun Liu;Yuanyuan Zhu;Zhenghao Dong;Shuai Qiu;Jiayi Wang;Li Lin;Zhiqiang Shen;Wenjin Yan;Kairong Wang;Rui Wang |
| 2 | Antifungal effect and action mechanism of antimicrobial peptide polybia-CP | 期刊论文 | Wang Kairong;Jia Fengjing;Dang Wen;Zhao Yanyan;Zhu Ranran;Sun Mengyang;Qiu Shuai;An Xiaoping;Ma Zelin;Zhu Yuanyuan;Yan Jiexi;Kong Ziqing;Yan Wenjin;Wang Rui |
| 3 | Antimicrobial activity and stability of the D-amino acid substituted derivatives of antimicrobial peptide polybia-MPI | 期刊论文 | Zhao Yanyan;Zhang Min;Qiu Shuai;Wang Jiayi;Peng Jinxiu;Zhao Ping;Zhu Ranran;Wang Hailin;Li Yuan;Wang Kairong;Yan Wenjin;Wang Rui |
| 4 | Antimicrobial activity and stability of protonectin with D-amino acid substitutions | 期刊论文 | Shuai Qiu;RanRan Zhu;Yanyan Zhao;Xiaoping An;Fengjing Jia;Jinxiu Peng;Zelin Ma;Yuanyuan Zhu;Jiayi Wang;Jinhuan Su;Qingjun Wang;Hailin Wang;Yuan Li;Kairong Wang;Wenjin Yan;Rui Wang |
| 5 | Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction | 期刊论文 | Yuanyuan Zhu;Zhenghao Dong;Xin Cheng;Xiaoling Zhong;Xiaolin Liu;Li Lin;Zhiqiang Shen;Peiju Yang;Yuan Li;Hailin Wang;Wenjin Yan;Kairong Wang;Rui Wang |
| 6 | D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP | 期刊论文 | Fengjing Jia;Jiayi Wang;JInxiu Peng;Ping Zhao;Ziqing Kong;Kairong Wang;Wenjin Yan;Rui Wang |
| 7 | Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction | 期刊论文 | Yuanyuan Zhu;Boyu Li;Cui Wang;Zhenghao Dong;Xiaoling Zhong;Kairong Wang;Wenjin Yan;Rui Wang |
| 8 | Asymmetric Synthesis of 2’-Trifluoromethylated Spiro-pyrrolidine-3,3’-oxindoles via Squaramide-Catalyzed Umpolung and 1,3-Dipolar Cycloaddition | 期刊论文 | Jinhuan Su;Zelin Ma;Xiaoyuan Li;Li Lin;Zhiqiang Shen;Peiju Yang;Yuan Li;Hailin Wang;Wenjin Yan;Kairong Wang;Rui Wang |
| 9 | Research on Peptide Toxins with Antimicrobial Activities | 期刊论文 | Kairong Wang;Yazhou Li;Yuanyuan Xia;Changxiao Liu |
| 10 | Asymmetric Synthesis of -Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction | 期刊论文 | Zhenghao DOng;Yuanyuan Zhu;Boyu Li;Cui Wang;Wenjin Yan;Kairong Wang;Rui Wang |
| 11 | The in vitro, in vivo antifungal activity and the action mode of Jelleine‑I against Candida species | 期刊论文 | Fengjing Jia;Jiayi Wang;Jinxiu Peng;Ping Zhao;Ziqing Kong;Kairong Wang;Wenjin Yan;Rui Wang |
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