肿瘤靶向穿膜肽的设计、合成及影响肿瘤靶向性相关因素分析

81473095
2014
H3401.合成药物化学
王锐
面上项目
教授
兰州大学
90万元
药物设计与合成;作用机制;肿瘤靶向穿膜肽;构效关系
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Novel antimicrobial peptide CPF-C1 analogs with superior stabilities and activities against multidrug-resistant bacteria 期刊论文 Xie Junqiu;Zhao Qian;Jiang Xianxing;Wang Rui;Xie Junqiu;Li Sisi;Yan Zhibin;Li Jing;Li Yao;Mou Lingyun;Zhang Bangzhi;Yang Wenle;Miao Xiaokang;Wang Rui;Jiang XX;Wang R
2 MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile 期刊论文 Liu Xin;Zhao Long;Wang Yuan;Zhou Jingjing;Wang Dan;Zhang Yixin;Zhang Xianghui;Wang Zhaojuan;Yang Dongxu;Mou Lingyun;Wang Rui;Wang R
3 Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m) RVD-hemopressin(alpha) and (m)VD-hemopressin(alpha) on memory in novel object and object location recognition tasks in normal young and A beta(1-42)-treated mice 期刊论文 Zhang Rui-san;He Zhen;Jin Wei-dong;Wang Rui;Zhang Rui-san;Wang R
4 Catalytic desymmetrization of meso-aziridines with benzofuran-2(3H)-ones employing a simple in-situ generated magnesium catalyst. 期刊论文 王锐
5 Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice 期刊论文 Li X. -H.;Lin M. -L.;Wang Z. -L.;Wang P.;Tang H. -H.;Lin Y. -Y.;Li N.;Fang Q.;Wang R.;Fang Q;Wang R
6 Catalytic asymmetric construction of pyrroloindolines via an in situ generated magnesium catalyst. 期刊论文 Wang Linqing;Yang Dongxu;Han Fengxia;Li Dan;Zhao Depeng;Wang Rui
7 Asymmetric Dearomative Halogenation of beta-Naphthols: The Axial Chirality Transfer Reaction 期刊论文 Wang Pengxin;Wang Jie;Wang Linqing;Li Dan;Wang Kezhou;Liu Yuyang;Zhu Haiyong;Liu Xihong;Yang Dongxu;Wang Rui;Wang Rui;Yang DX;Wang R;Wang R
8 The Important Role of the Byproduct Triphenylphosphine Oxide in the Magnesium(II)-Catalyzed Enantioselective Reaction of Hemiacetals and Phosphorus Ylides 期刊论文 Wang Linqing;Yang Dongxu;Li Dan;Liu Xihong;Wang Pengxin;Wang Kezhou;Zhu Haiyong;Bai Lutao;Wang Rui;Yang DX;Wang R
9 Diversiform Reactivity of Naphthols in Asymmetric Dearomatization or O-Alkylation Reactions with Aziridines 期刊论文 Wang Linqing;Yang Dongxu;Li Dan;Zhu Haiyong;Wang Pengxin;Liu Xihong;Bai Lutao;Wang Rui;Yang DX;Wang R
10 Magnesium Catalysis Mediated Tetrazoles in Desymmetrization Reaction of Aziridines 期刊论文 Li Dan;Wang Kezhou;Wang Linqing;Wang Yuan;Wang Pengxin;Liu Xin;Yang Dongxu;Wang Rui;Yang DX;Wang R
11 BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice 期刊论文 Li Ning;Han Zheng-lan;Wang Zi-long;Xing Yan-hong;Sun Yu-long;Li Xu-hui;Song Jing-jing;Zhang Ting;Zhang Run;Zhang Meng-na;Xu Biao;Fang Quan;Wang Rui
12 The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species 期刊论文 Jia Fengjing;Wang Jiayi;Peng Jinxiu;Zhao Ping;Wang Kairong;Yan Wenjin;Wang Rui;Kong Ziqing;Wang KR;Yan WJ;Wang R
13 Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m) RVD-hemopressin(alpha) and (m)VD-hemopressin(alpha) on memory in novel object and object location recognition tasks in normal young and A beta(1-42)-treated mice 期刊论文 Zhang Rui-san;He Zhen;Jin Wei-dong;Wang Rui
14 Intermolecular enantioselective dearomatization reaction of beta-naphthol using meso-aziridine: a bifunctional in situ generated magnesium catalyst. 期刊论文 Yang Dongxu;Wang Linqing;Han Fengxia;Li Dan;Zhao Depeng;Wang Rui
15 Mg-II-Mediated Catalytic Asymmetric Dearomatization (CADA) Reaction of beta-Naphthols with Dialkyl Acetylenedicarboxylates 期刊论文 Wang Linqing;Yang Dongxu;Li Dan;Wang Pengxin;Wang Kezhou;Wang Jie;Jiang Xianxing;Wang Rui
16 Cell penetrating peptide TAT can kill cancer cells via membrane disruption after attachment of camptothecin. 期刊论文 Song Jingjing;Zhang Yun;Zhang Wei;Chen Jianbo;Yang Xiaoli;Ma Panpan;Zhang Bangzhi;Liu Beijun;Ni Jingman;Wang Rui
17 Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons 期刊论文 Li Dan;Yang Dongxu;Wang Linqing;Liu Xihong;Wang Rui;Jiang Xianxing;Yang DX;Wang R;Jiang XX
18 Mg-II-Mediated Catalytic Asymmetric Dearomatization (CADA) Reaction of beta-Naphthols with Dialkyl Acetylenedicarboxylates 期刊论文 Wang Linqing;Yang Dongxu;Li Dan;Wang Pengxin;Wang Kezhou;Wang Jie;Wang Rui;Jiang Xianxing;Yang DX;Wang R;Jiang XX
19 beta-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G(2)/M phase transition 期刊论文 Zhang Yi-Xin;Li Xiao-Fang;Hu Hui;Song Xiao-Yun;Li Jing-Yi;Miao Xiao-Kang;Zhou Tian-Xiong;Yang Wen-Le;Zhang Xiao-Wei;Mou Ling-Yun;Wang Rui;Zhang Yi-Xin;Li Xiao-Fang;Yuan Guo-Qiang;Hu Hui;Song Xiao-Yun;Li Jing-Yi;Miao Xiao-Kang;Zhou Tian-Xiong;Yang Wen-Le;Zhang Xiao-Wei;Mou Ling-Yun;Wang Rui;Yuan Guo-Qiang;Mou LY;Wang R
20 手性α、γ二氨基二酸衍生物及其合成方法 专利 王锐;孙旺盛;杨君贤
21 Development of Biligands Magnesium Catalysis in Asymmetric Conjugate Reactions of C3-Pyrrolyl-Oxindoles 期刊论文 Wang Kezhou;Wang Linqing;Liu Xihong;Li Dan;Zhu Haiyong;Wang Pengxin;Liu Yuyang;Yang Dongxu;Wang Rui;Yang DX;Wang R
22 基于内吗啡肽2或Biphalin的棕榈酰化修饰的阿片肽类似物及其合成和应用 专利 王锐;方泉;王沛;张婷;王子龙;李宁
23 Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols 期刊论文 Yang Dongxu;Wang Linqing;Kai Ming;Li Dan;Yao Xiaojun;Wang Rui
24 Construction of Vicinal All-Carbon Quaternary Stereocenters Enabled by a Catalytic Asymmetric Dearomatization Reaction of beta-Naphthols with 3-Bromooxindoles 期刊论文 Liu Xihong;Wang Pengxin;Bai Lutao;Li Dan;Wang Linqing;Yang Dongxu;Wang Rui;Wang LQ;Wang R
25 Effects of linker amino acids on the potency and selectivity of dimeric antimicrobial peptides 期刊论文 Kai Ming;Liu Liwei;Huang Sujie;Li Xiao;Zhang Bangzhi;Zhang Wei;Xie Huan;Zhang Zhengzheng;Liu Yuyang;Song Jingjing;Wang Rui;Song JJ;Wang R
26 Catalytic Asymmetric [3+2] Cyclization Reactions of 3-lsothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst 期刊论文 Wang Linqing;Yang Dongxu;Li Dan;Liu Xihong;Zhao Qian;Zhu Ranran;Zhang Bangzhi;Wang Rui
27 Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons 期刊论文 Li Dan;Yang Dongxu;Wang Linqing;Liu Xihong;Jiang Xianxing;Wang Rui
28 一种具有多靶点的抗菌多肽偶联物及其二聚物的合成和应用 专利 王锐;宋竟婧;张伟;张邦治
29 Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities 期刊论文 Fang Quan;Wang Rui;Fang Q;Wang R
30 Activation of NPFF2 receptor stimulates neurite outgrowth in Neuro 2A cells through activation of ERK signaling pathway 期刊论文 Yu Hong-ping;Zhang Nan;Zhang Ting;Wang Zi-long;Li Ning;Tang Hong-hai;Zhang Run;Zhang Meng-na;Xu Biao;Fang Quan;Wang Rui;Fang Q;Wang R
31 多位点组合修饰的内吗啡肽类似物及其合成和应用 专利 王锐;王媛;刘鑫;赵龙
32 Nickel-Mediated Asymmetric Allylic Alkylation between Nitroallylic Acetates and Acyl Imidazoles 期刊论文 Wang Jie;Wang Pengxin;Wang Linqing;Li Dan;Wang Kezhou;Wang Yuan;Zhu Haiyong;Yang Dongxu;Wang Rui;Yang DX;Wang R
33 Endomorphin-1 attenuates Abeta42 induced impairment of novel object and object location recognition tasks in mice. 期刊论文 Zhang Rui-San;Xu Hong-Jiao;Jiang Jin-Hong;Han Ren-Wen;Chang Min;Peng Ya-Li;Wang Yuan;Wang Rui
34 Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities 期刊论文 Wang Zi-Long;Pan Jia-Xin;Song Jing-Jing;Tang Hong-Hai;Yu Hong-Ping;Li Xu-Hui;Li Ning;Zhang Ting;Zhang Run;Zhang Meng-Na;Xu Biao;Fang Quan;Wang Rui
35 Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice 期刊论文 Pan Jia-Xin;Wang Zi-Long;Li Ning;Zhang Nan;Wang Pei;Tang Hong-Hai;Zhang Ting;Yu Hong-Ping;Zhang Run;Zheng Ting;Fang Quan;Wang Rui
36 Endomorphin-1 analogs containing alpha-methyl-beta-amino acids exhibit potent analgesic activity after peripheral administration 期刊论文 Wang Yuan;Yang Junxian;Liu Xin;Zhao Long;Yang Dongxu;Zhou Jingjing;Wang Dan;Mou Lingyun;Wang Rui;Wang R
37 An Efficient Nickel-Catalyzed Asymmetric Oxazole-Forming Ugi-Type Reaction for the Synthesis of Chiral Aryl-Substituted THIQ Rings 期刊论文 Li Dan;Yang Dongxu;Wang Linqing;Liu Xihong;Wang Kezhou;Wang Jie;Wang Pengxin;Liu Yuyang;Zhu Haiyong;Wang Rui;Wang Rui;Yang DX;Wang R;Wang R
38 Antimicrobial activity and stability of the D-amino acid substituted derivatives of antimicrobial peptide polybia-MPI 期刊论文 Zhao Yanyan;Qiu Shuai;Wang Jiayi;Peng Jinxiu;Zhao Ping;Zhu Ranran;Wang Kairong;Yan Wenjin;Wang Rui;Zhang Min;Wang Hailin;Li Yuan;Wang KR;Yan WJ;Wang R
39 Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles 期刊论文 Wang Linqing;Li Dan;Yang Dongxu;Wang Kezhou;Wang Jie;Wang Pengxin;Su Wu;Wang Rui
40 Structure-constrained endomorphin analogs display differential antinociceptive mechanisms in mice after spinal administration 期刊论文 Wang Yuan;Zhou Jingjing;Liu Xin;Zhao Long;Wang Zhaojuan;Zhang Xianghui;Wang Kezhou;Wang Linqing;Wang Rui;Wang R
41 Antimicrobial peptide protonectin disturbs the membrane integrity and induces ROS production in yeast cells 期刊论文 Wang Kairong;Dang Wen;Xie Junqiu;Zhu Ranran;Sun Mengyang;Jia Fengjing;Zhao Yanyan;An Xiaoping;Qiu Shuai;Li Xiaoyuan;Ma Zelin;Yan Wenjin;Wang Rui;Yan WJ
42 Asymmetric anti-selective Michael reaction of imidazole-modified ketones with trans-beta-nitroalkenes. 期刊论文 Yang Dongxu;Wang Linqing;Li Dan;Han Fengxia;Zhao Depeng;Wang Rui
43 基于内吗啡肽2和NPFF受体拮抗剂RF9的分叉型杂交肽及其合成方法和应用 专利 王锐;方泉;李宁;韩政岚;王子龙
44 Antimicrobial activities and action mechanism studies of transportan 10 and its analogues against multidrug-resistant bacteria 期刊论文 Xie Junqiu;Gou Yuanmei;Zhao Qian;Li Sisi;Zhang Wei;Song Jingjing;Mou Lingyun;Li Jingyi;Wang Kairong;Zhang Bangzhi;Yang Wenle;Wang Rui
45 Asymmetric anti-selective Michael reaction of imidazole-modified ketones with trans-beta-nitroalkenes. 期刊论文 Yang Dongxu;Wang Linqing;Li Dan;Han Fengxia;Zhao Depeng;Wang Rui
查看更多信息请先登录或注册