去乙酰化酶SIRT2调控凋亡相关因子Septin4在高血压肾损伤疾病中的作用及其机制研究
81900372
2019
H0213.血压调节异常与高血压病
张莹
青年科学基金项目
研究员
中国医科大学
21万元
沉默因子2;去乙酰化修饰;高血压肾损伤;靶向治疗;细胞分裂/GTP结合蛋白4
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 脱乙酰化修饰的septin4蛋白及其制药用途 | 专利 | 孙英贤;张莹;张乃今 |
| 2 | BAF155突变基因及其制药用途 | 专利 | 孙英贤;张乃今;张莹 |
| 3 | WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy | 期刊论文 | Zhang Ying;You Shilong;Tian Yichen;Lu Saien;Cao Liu;Sun Yingxian;Zhang Naijin |
| 4 | The role of SIRT2 in vascular‐related and heart‐related diseases: A review | 期刊论文 | Boquan Wu;Shilong You;Hao Qian;Shaojun Wu;Saien Lu;Ying Zhang;Yingxian Sun;Naijin Zhang |
| 5 | The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis | 期刊论文 | Fei Yi;Ying Zhang;Zhijun Wang;Zhuo Wang;Ziwei Li;Tingting Zhou;Hongde Xu;Jingwei Liu;Bo Jiang;Xiaoman Li;Liang Wang;Ning Bai;Qiqiang Guo;Yi Guan;Yanling Feng;Zhiyong Mao;Guangjian Fan;Shengping Zhang;Chuangui Wang;Longyue Cao;Brian P. O’Rourke;Yang Wang;Yanmei Wu;Boquan Wu;Shilong You;Naijin Zhang;Junlin Guan;Xiaoyu Song;Yingxian Sun;Shi Wei;Liu Cao |
| 6 | Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy | 期刊论文 | Ying Zhang;Naijin Zhang;Yuanming Zou;Chunyu Song;Kexin Cao;Boquan Wu;Shilong You;Saien Lu;Dong Wang;Jiaqi Xu;Xinyue Huang;Pengyu Zhang;Zihao Fan;Jingwei Liu;Zhongyi Cheng;Zhe Zhang;Chuize Kong;Liu Cao;Yingxian Sun |
| 7 | Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation | 期刊论文 | Zhang Naijin;Zhang Ying;You Shilong;Tian Yichen;Lu Saien;Cao Liu;Sun Yingxian |
| 8 | 多肽GL42的制药用途 | 专利 | 孙英贤;张乃今;张莹;郝丽英 |
| 9 | 高血压及其相关疾病靶器官保护策略的基础临床研究及转化应用 | 奖励 | 孙英贤;张乃今;张莹;孙国哲;李昭;徐礼胜;叶宁;成正辉;郭潇繁;王军;周颖 |
| 10 | DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53 | 期刊论文 | Pengbo Wang;Boquan Wu;Shilong You;Saien Lu;Shengjun Xiong;Yuanming Zou;Pengyu Jia;Xiaofan Guo;Ying Zhang;Liu Cao;Yingxian Sun;Naijin Zhang |
| 11 | Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury | 期刊论文 | Naijin Zhang;Ying Zhang;Boquan Wu;Shaojun Wu;Shilong You;Saien Lu;Jingwei Liu;Xinyue Huang;Jiaqi Xu;Liu Cao;Yingxian Sun |
| 12 | Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling | 期刊论文 | Naijin Zhang;Ying Zhang;Hao Qian;Shaojun Wu;Liu Cao;Yingxian Sun |
| 13 | The Role of BRG1 in Antioxidant and Redox Signaling | 期刊论文 | Shilong You;Ying Zhang;Jiaqi Xu;Hao Qian;Shaojun Wu;Boquan Wu;Saien Lu;Yingxian Sun;Naijin Zhang |
| 14 | 脱乙酰化修饰的BAF155蛋白及其制药用途 | 专利 | 孙英贤;张乃今;张莹 |
| 15 | E3 Ubiquitin ligase NEDD4 family‑regulatory network in cardiovascular disease | 期刊论文 | Ying Zhang;Hao Qian;Boquan Wu;Shilong You;Shaojun Wu;Saien Lu;Pingyuan Wang;Liu Cao;Naijin Zhang;Yingxian Sun |
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