布鲁氏菌关键毒力因子在持续性感染中的分子致病机制研究
U1803236
2018
陈创夫
联合基金项目
教授
石河子大学
245万元
分子机制;持续性感染;毒力因子;调控通路;布鲁氏菌
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Abortion and various associated risk factors in dairy cow and sheep in Ili, China | 期刊论文 | Huan Zhang;Xiaoyu Deng;Buyun Cui;Zhiran Shao;Xiaoli Zhao;Qin Yang;Shengnan Song;Zhen Wang;Yong Wang;Yuanzhi Wang;Zhengfei Liu;Jinliang Sheng;Chuangfu Chen |
| 2 | 羊种布鲁氏菌M5-90疫苗株铁应答调控因子irr和rirA基因缺失株的构建与鉴定 | 期刊论文 | 赵晓丽;王奔奔;张欢;杨亚军;杨宁宁;王震;杨琴;王勇;陈创夫;曹旭东 |
| 3 | Nucleomodulin BspJ as an effector promotes the colonization of Brucella abortus in the host | 期刊论文 | Zhongchen Ma;Shuifa Yu;Kejian Cheng;Yuhe Miao;Yimei Xu;Ruirui Hu;Wei Zheng;Jihai Yi;Hui Zhang;Ruirui Li;Zhiqiang Li;Yong Wang;Chuangfu Chen |
| 4 | LRRK2 Kinase Plays an Important Role in the Intracellular Survival of Brucella abortus 2308 in Murine Macrophages and in a Mouse Infection Model | 期刊论文 | Jihai Yi;dong xiao yu;shao zhiran;wang yueli;zhang huan;he jinke;wu wenxing;wang benben;Wang Zhen;Chen chuangfu |
| 5 | miR-145a-3p通过靶向ATG14调控布鲁氏菌诱导的RAW264.7自噬 | 期刊论文 | 王月丽;邵志然;易继海;王勇;王震;陈创夫 |
| 6 | 线粒体融合蛋白2基因干扰与过表达对布鲁氏菌诱导巨噬细胞凋亡的影响 | 期刊论文 | 谢珊珊;杨琴;邓肖玉;易继海;王震;陈创夫 |
| 7 | Brucella induces M1 to M2 polarization of macrophages through STAT6 signaling pathway to promote bacterial intracellular survival | 期刊论文 | Yueli Wang;Jing Xi;Jihai Yi;Chuang Meng;Xiaoli Zhao;Zhihua Sun;Huan Zhang;Xiaoyu Deng;Zhongchen Ma;Honghuan Li;Yong Wang;Chuangfu Chen |
| 8 | Small ubiquitin-related modifier 2 affects the intracellular survival of Brucella abortus 2308 by regulating activation of the NF-jB pathway | 期刊论文 | Yueli Wang;Jihai Yi;Chuangfu chen |
| 9 | Insights into irr and rirA gene regulation on the virulence of Brucella melitensis M5-90. | 期刊论文 | Huan Zhang;Benben Wang;Wenxing Wu;Xiaoyu Deng;Zhiran Shao;Jihai Yi;Zhen Wang;Ningning Yang;Yong Wang;Yuanzhi Wang;Chuangfu Chen |
| 10 | 新疆某地区3个牧场布鲁氏菌病流行状况调查及分析 | 期刊论文 | 杨琴;邓肖玉;张欢;易继海;王勇;张倩;王震;陈创夫 |
| 11 | The Deletion of Omp19 Gene of Brucella abortus 2308 Reduces Its Survival in Mouse Macrophage and in Mice | 期刊论文 | Yueli WANG;MA Zhongchen;Huan ZHANG;YI Jihai;Yong WANG;LI Tiansen;Chuangfu CHEN |
| 12 | Interaction between Brucella melitensis 16M and small ubiquitin-related modifier 1 and E2 conjugating enzyme 9 in mouse RAW264.7 macrophages | 期刊论文 | Jihai Yi;Yueli Wang;Qifeng Li;Huan Zhang;Zhiran Shao;XiaoYu Deng;Jinke He;Chencheng Xiao;Zhen Wang;Yong Wang;Chuangfu Chen |
| 13 | 泛素相关修饰蛋白SUMO-2对RAW264.7细胞内布鲁氏菌16M存活的影响 | 期刊论文 | 邓肖玉;易继海;李启峰;何金科;杨琴;王月丽;王震;王勇;陈创夫 |
| 14 | STAT6介导的巨噬细胞极化对布鲁氏菌胞内存活的影响 | 期刊论文 | 席静;王月丽;邓肖玉;杨琴;李培东;张江伟;孙天浩;朱良全;易继海;陈创夫 |
| 15 | 布鲁氏菌LPS合成相关重要蛋白的生物信息学分析及per基因的克隆表达 | 期刊论文 | 孙天浩;易德武;张倩;李楠;苗玉和;王震;陈创夫 |
| 16 | 家畜布鲁氏菌病相关疫苗的研究进展 | 期刊论文 | 孙天浩;马忠臣;张欢;程科建;陈创夫;王震;张倩 |
| 17 | 牛种布鲁氏菌A19 VirB启动子缺失株的构建及其生物学特性研究 | 期刊论文 | 邓肖玉;何金科;杨琴;易继海;王月丽;席静;王震;陈创夫 |
| 18 | Interferon-Inducible Transmembrane Protein 3-Containing Exosome as a New Carrier for the Cell-to-Cell Transmission of Anti-Brucella Activity | 期刊论文 | Jihai Yi;Yueli Wang;Hui Zhang;Xiaoyu Deng;Jing Xi;Honghuan Li;Ningning Yang;Zhongchen Ma;Yong Wang;Chuangfu Chen |
| 19 | Using a Relative Quantitative Proteomic Method to Identify Differentially Abundant Proteins in Brucella melitensis Biovar 3 and Brucella melitensis M5-90 | 期刊论文 | Huan Zhang;Yueli Wang;Yifan Wang;Xiaoyu Deng;Taiwang Ji;Zhongchen Ma;Ningning Yang;Mingguo Xu;Honghuan Li;Jihai Yi;Yong Wang;Yuanzhi Wang;Jinliang Sheng;Zhen Wang;Chuangfu Chen |
| 20 | 牛种布鲁氏菌Ⅳ型分泌系统对巨噬细胞内质网应激和细胞凋亡的影响 | 期刊论文 | 杨琴;邓肖玉;谢珊珊;易继海;王勇;张倩;王震;陈创夫 |
| 21 | A case report of endocarditis and spondylitis caused by Brucella melitensis biovar 3 | 期刊论文 | Zhang Huan;Xie Songsong;Wang Yueli;Zhao Xiaoli;Yi Jihai;Wang Zhen;Liu Qi;Deng Xiaoyu;Li Bingjie;Cui Buyun;Wang Yuanzhi;Chen Chuangfu |
| 22 | Immunochromatographic Test Strip and Its Preparation Method for Brucella Antibody of Zoonoses | 专利 | CHEN Chuangfu;MIAO Yuhe;GUO Haiyan;ZHANG Huiand;WANG Zhen;SHI Feng;LU Zhizi;MENG Ru |
| 23 | 布鲁氏菌持续性感染机制研究进展 | 期刊论文 | 张倩;孙天浩;张辉;王震;陈创夫 |
| 24 | Crosstalk of Brucella abortus nucleomodulin BspG and host DNA replication process/mitochondrial respiratory pathway promote anti-apoptosis and infection | 期刊论文 | Zhongchen Ma;Xiaoyu Deng;Ruirui Li;Ruirui Hu;Yuhe Miao;Yimei Xu;Wei Zheng;Jihai Yi;Zhen Wang;Yong Wang;Chuangfu Chen |
| 25 | 泛素偶联酶Ubc-9对布鲁氏菌胞内生存及细胞凋亡的影响 | 期刊论文 | 邵志然;李启峰;易继海;张欢;陈创夫;王震 |
| 26 | 布鲁菌M5疫苗株感染对宿主细胞自噬溶酶体途径的影响 | 期刊论文 | 杨宁宁;张倩;易继海;王震;陈创夫 |
| 27 | Deletion of the type IV secretion system promoter VirB in Brucella abortus A19 strain attenuated the virulence of the bacteria and promotes autophagy | 期刊论文 | Xiaoyu Deng;Jinke He;Yueli Wang;Qin Yang;Ji Hai Yi;Hui Zhang;Yong Wang;Yuhe Miao;Zhen Wang;Chuangfu Chen |
| 28 | 布鲁氏菌BspG基因缺失对其部分生物学活性影响的研究 | 期刊论文 | 于水发;马忠臣;徐艺玫;苗玉和;胡瑞瑞;王震;易继海;李志强;王勇;陈创夫 |
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