炎症抑制因子SIRT1通过调控PKM2核/浆分布阻抑代谢-炎症偶联的机制研究

81871606
2018
H1605.急重症医学研究新技术与新方法
张力
面上项目
教授
重庆医科大学
57万元
乙酰化;炎症;糖酵解;沉默信息调节因子2相关酶1;M2型丙酮酸激酶
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1 期刊论文 Lv Xiaohui;Zhou Honghong;Hu Kai;Lin Ling;Yang Yongqiang;Li Longjiang;Tang Li;Huang Jiayi;Shen Yi;Jiang Rong;Wan Jingyuan;Zhang Li
2 The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice 期刊论文 Zhou Dan;Yang Feng;Lin Ling;Tang Li;Li Longjiang;Yang Yongqiang;Liu Dingrong;Zhang Chong;Wu Tong;Wei Huijie;Zhang Xiaoming;Zhang Li
3 Nuclear accumulation of pyruvate kinase M2 promotes liver regeneration via activation of signal transducer and activator of transcription 3 期刊论文 Hu Kai;Xu Juanjuan;Fan Kerui;Zhou Dan;Li Longjiang;Tang Li;Peng Xianwen;Zhang Li;Wang Yaping
4 The mitochondria-targeting antioxidant MitoQ alleviated lipopolysaccharide/D-galactosamine-induced acute liver injury in mice 期刊论文 Hu Kai;Xiao Lidan;Li Longjiang;Shen Yi;Yang Yongqiang;Huang Jiayi;Wang Yaping;Zhang Li;Wen Sha;Tang Li
5 乳酸脱氢酶抑制剂减轻内毒素诱导的小鼠急性肝损伤 期刊论文 昝欣言;杨梦欣;张馨月;杨永强;张力
6 Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway 期刊论文 Peng Xianwen;Yang Yongqiang;Tang Li;Wan Jingyuan;Dai Jie;Li Longjiang;Huang Jiayi;Shen Yi;Lin Ling;Gong Xianqiong;Zhang Li
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