三七皂苷体内代谢产物与药效关联性研究

81530096
2015
H32.中药学
王峥涛
重点项目
教授
上海中医药大学
273万元
三七皂苷;血小板P2Y12受体;体内代谢产物;双向调节;止血/活血
2016-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Fully automated chip-based nanoelectrospray ionization-mass spectrometry as an effective tool for rapid and high-throughput screening of 5α-reductase inhibitors 期刊论文 Zheng Ruirong;Li Linnan;Deng Xueli;Tian Mei;Wang Zhengtao;Yang Li
2 Recent advances in applications of metal–organic frameworks for sample preparation in pharmaceutical analysis 期刊论文 Li Linnan;Chen Yilin;Yang Li;Wang Zhengtao;Liu Huwei
3 Dammarane-type triterpene oligoglycosides from the leaves and stems of Panax notoginseng and their antiinflammatory activities 期刊论文 Li Juan;Wang Rufeng;Zhou Yue;Hu Haijun;Yang Yingbo;Yang Li;Wang Zhengtao
4 Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation 期刊论文 Cao Yin;Li Qinglin;Liu Lulu;Wu Hui;Huang Fei;Wang Changhong;Lan Yunyi;Zheng Fang;Xing Faping;Zhou Qiang;Li Qi;Shi Hailian;Zhang Beibei;Wang Zhengtao;Wu Xiaojun
5 Notoginsenoside Ft1 Promotes Fibroblast Proliferation via PI3K/Akt/mTOR Signaling Pathway and Benefits Wound Healing in Genetically Diabetic Mices 期刊论文 Zhang Eryun;Gao Bo;Yang Li;Wu Xiaojun;Wang Zhengtao
6 Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System 期刊论文 Yue Bei;Luo Xiaoping;Yu Zhilun;Mani Sridhar;Wang Zhengtao;Dou Wei
7 三七皂苷R1的医药用途 专利 王峥涛;张二云;高波;黄玲芳;杨莉;吴晓俊
8 Dose-dependent exposure profile and metabolic characterization of notoginsenoside R-1 in rat plasma by ultra-fast liquid chromatography-electrospray ionization-tandem mass spectrometry 期刊论文 Zhang Sainan;Ju Zhengcai;Guan Huida;Yu Lu;Wang Zhengtao;Zhao Yuqing
9 越南人参皂苷R7抑制LPS及TNF-α联合诱导大鼠星形胶质细胞C6的激活作用研究 期刊论文 王晓双;黄韬;秦力悦;李鸿丽;兰云意;吴辉;张蓓蓓;石海莲;吴晓俊;王峥涛
10 三七皂苷Ft1抑制乳腺癌细胞增殖、迁移及促进凋亡的机制研究 期刊论文 邱水平;李鸿丽;石海莲;吴辉;黄菲;张蓓蓓;吴晓俊;王峥涛
11 Localization of constituents for determining the age and parts of ginseng through ultraperfomance liquid chromatography quadrupole/time of flight-mass spectrometry combined with desorption electrospray ionization mass spectrometry imaging 期刊论文 Yang Yuangui;Yang Yingbo;Qiu Hao;Ju Zhengcai;Shi Yanchao;Wang Zhengtao;Yang Li
12 Identification and quantitative investigation of the effects of intestinal microflora on the metabolism and pharmacokinetics of notoginsenoside Fc assayed by liquid chromatography/electrospray ionization tandem mass spectrometry 期刊论文 Ju Zhengcai;Li Jia;Lu Qian;Yang Yingbo;Yang Li;Wang Zhengtao
13 Gypenoside IX Suppresses p38 MAPK/Akt/NF kappa B Signaling Pathway Activation and Inflammatory Responses in Astrocytes Stimulated by Proinflammatory Mediators 期刊论文 Wang Xiaoshuang;Yang Liu;Yang Li;Xing Faping;Yang Hua;Qin Liyue;Lan Yunyi;Wu Hui;Zhang Beibei;Shi Hailian;Lu Cheng;Huang Fei;Wu Xiaojun;Wang Zhengtao
14 一种三七皂苷Ft1的用途 专利 杨莉;王峥涛;丁丽丽;张二云
15 Phytochemical analysis of Panax species: a review 期刊论文 Yang Yuangui;Ju Zhengcai;Yang Yingbo;Zhang Yanhai;Yang Li;Wang Zhengtao
16 三七皂苷Ft1的用途 专利 窦薇;王峥涛;张晶晶;丁丽丽;孙阿宁;张二云
17 Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth 期刊论文 Zhang Eryun;Shi Hailian;Yang Li;Wu Xiaojun;Wang Zhengtao
18 三七皂苷Fc的制药用途 专利 王峥涛;高波;杨莉;吴晓俊;张二云;黄玲芳
19 Silicone elastomer gel impregnated with 20(S)- protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery 期刊论文 Sun Di;Guo Shiyan;Yang Li;Wang Yaru;Wei Xiaohui;Song Sha;Yang Yiwei;Gan Yong;Wang Zhengtao
20 Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes 期刊论文 Li Jia;He Chunyong;Fang Lianxiang;Yang Li;Wang Zhengtao
21 Advances on hormone-like activity of Panax ginseng and ginsenosides 期刊论文 Tian Mei;Li Linnan;Zheng Ruirong;Yang Li;Wang Zhengtao
22 基于人参皂苷Ro/Re比例的红参质量标准研究 期刊论文 杨远贵;杨颖博;鞠政财;张艳海;杨莉;王峥涛
23 三七素的用途 专利 窦薇;王峥涛;张晶晶;丁丽丽;孙阿宁;张二云
24 20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice 期刊论文 Zhang Eryun;Gao Bo;Shi Hailian;Huang Lingfang;Yang Li;Wu Xiaojun;Wang Zhengtao
25 Stem-leaf saponins from Panax notoginseng counteract aberrant autophagy and apoptosis in hippocampal neurons of mice with cognitive impairment induced by sleep deprivation 期刊论文 Cao Yin;Yang Yingbo;Wu Hui;Lu Yi;Wu Shuang;Liu Lulu;Wang Changhong;Huang Fei;Shi Hailian;Zhang Beibei;Wu Xiaojun;Wang Zhengtao
26 三七皂苷Fc的医药用途 专利 王峥涛;高波;杨莉;吴晓俊
27 Ginsenosides in Panax genus and their biosynthesis 期刊论文 Hou Maoqi;Wang Rufeng;Zhao Shujuan;Wang Zhengtao
28 液滴萃取表面分析-质谱法用于新鲜与蒸制三七根切片中皂苷成分的快速鉴别 期刊论文 田妹;李林楠;杨远贵;杨莉;王峥涛
29 一种原人参二醇型三七皂苷的制药用途 专利 王峥涛;高波;吴晓俊;杨莉;刘青;尉小慧;张二云;黄玲芳;何纯勇
30 三七皂苷ST-4的医药用途 专利 王峥涛;张二云;王如锋;高波;刘青;吴晓俊;杨莉
31 三七皂苷Ft1的医药用途 专利 王峥涛;高波;杨莉;吴晓俊
32 A rapid and sensitive UHPLC-MS/MS method for the determination of Notoginsenoside Ft1 in rat plasma with application to pharmacokinetic study 期刊论文 Ju Zhengcai;He Chunyong;Li Jia;Yang Li;Wang Zhengtao
33 Advance in glycosyltransferases, the important bioparts for production of diversified ginsenosides 期刊论文 Zhao Jianing;Wang Rufeng;Zhao Shujuan;Wang Zhengtao
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