PEDF表达降低介导IL-34刺激的滑膜MSC异常调控类风湿关节炎Tfh的机制研究

81671606
2016
H1107.自身免疫性疾病
李霞
面上项目
教授
大连医科大学
57万元
炎性细胞因子;滑膜间充质干细胞;滤泡辅助T细胞;类风湿关节炎;色素上皮细胞衍生因子
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway 期刊论文 Mahmoud Al-Azab;Wang Bing;Abdalkhalig Elkhider;Williams Walana;Li Weiping;Yuan Bo;Ye Yunshan;Tang Yawei;Marwan Almoiliqy;Salah Adlat;Wei Jing;Zhang Yan;Li Xia
2 TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation 期刊论文 Mahmoud Al-Azab;Eskandar Qaed;Ouyang Xunli Ouyang;Abdalkhalig Elkhider;Williams Walana;Li Han;Li Weiping;Tang Yawei;Salah Adlat;Wei Jing;Wang Bing;Li Xia
3 IL-34 modulates rheumatoid synovial fibroblast proliferation and migration via ERK/AKT signalling pathway 期刊论文 Abdalkhalig Elkhider;Wei Jing;Mahmoud Al-Azab;Tang Yawei;Williams Walana;Li Weiping;Yuan Bo;Ye Yunshan;Wang Guan;Zhang Yan;Li Xia
4 Upregulation of intestinal Barrier Function in Mice with Dss-induced colitis by a Defined Bacterial consortium is associated with expansion of il-17a Producing gamma Delta T cells 期刊论文 Li Ming;Wang Bing;Sun Xiaotong;Tang Yan;Wei Xiaoqing;Ge Biying;Tang Yawei;Deng Ying;He Chunyang;Yuan Jieli;Li Xia
5 白细胞介素-34对类风湿关节炎成纤维样滑膜细胞前列腺素E2/环氧化酶2表达的影响 期刊论文 Tang Yawei;Wang Bing;Sun Xiaotong;Ma Zijian;Li Xia;Zhang Yan
6 瘦素通过白细胞介素-6调控类风湿关节炎患者外周血调节性T细胞的增殖 期刊论文 Ye Yunshan;Li Han;Ouyang Xunli;Yuan Qihang;Wang Bing;Zhang Yan
7 Rheumatoid arthritis fibroblast-like synoviocytes co-cultured with PBMC increased peripheral CD41CXCR51ICOS1 T cell numbers 期刊论文 Tang Y;Wang B;Sun X;Li H;Ouyang X;Wei J;Dai B;Zhang Y;Li X
8 Leptin-induced migration and angiogenesis in rheumatoid arthritis is mediated by reactive oxygen species 期刊论文 Sun Xiaotong;Wei Jing;Tang Yawei;Wang Bing;Zhang Yan;Shi Lei;Guo Jianping;Hu Fanlei;Li Xia
9 Leptin: an unappreciated key player in SLE 期刊论文 Yuan Qihang;Chen Haifeng;Li Xia;Wei Jing
10 Aquaporin 5 promotes tumor migration and angiogenesis in non‑small cell lung cancer cell line H1299 期刊论文 Abdalkhalig Elkhider;Wang Bing;Ouyang Xunli;Mahmoud Al-Azab;Williams Walana;Sun Xiaotong;Li Han;Tang Yawei;Wei Jing;Li Xia
11 Circulating leptin level, soluble leptin receptor level and their gene polymorphism in patients with systemic lupus erythematosus: a systematic review and meta-analysis 期刊论文 Yuan Qihang;Zhang Lilong;Tian Yao;Li Weiping;Li Xia;Lu Zhimin
12 Increased IL-6 expression on THP-1 by IL-34 stimulation up-regulated rheumatoid arthritis Th17 cells 期刊论文 Wang Bing;Tang Yawei;Sun Xiaotong;Ouyang Xunli;Li Han;Wei Jing;Zhang Yan;Li Xia
13 Lymphocyte subset clustering analysis in treatment-naive patients with systemic lupus erythematosus 期刊论文 Lu Zhimin;Li Weiping;Tang Yawei;Da Zhanyun;Li Xia
14 Leptin Upregulates Peripheral CD4+ CXCR5+ ICOS+ T Cells Via Increased IL-6 in Rheumatoid Arthritis Patients 期刊论文 Wang Miaomiao;Wei Jing;Li Han;Ouyang Xunli;Sun Xiaotong;Tang Yawei;Chen Haifeng;Wang Bing;Li Xia
15 ER-stressed MSC displayed more effective immunomodulation in RA CD4+ CXCR5+ ICOS+ follicular helper-like T cells through higher PGE2 binding with EP2/EP4 期刊论文 Wei Jing;Ouyang Xunli;Tang Yawei;Li Han;Wang Bing;Ye Yunshan;Jin Minli;Mahmoud Al Azab;Li Weiping;Li Xia
16 IL-34对类风湿关节炎滑膜间充质干细胞色素上皮衍生因子表达的作用研究 期刊论文 Li Han;OuYang Xunli;Tang Yangwei;Zhang Yan;Li Xia;Wang Bing
17 Endoplasmic reticulum stress perpetuated toll-like receptor signalling-mediated inflammation in rheumatoid arthritis via X-box-binding protein-1 期刊论文 Hu Fanlei;Tang Yawei;Wang Ping;Bai Mingxin;Li Xin;Song Jing;Shi Lianjie;Sun Xiaotong;Jin Minli;Li Zhanguo;Li Xia
18 TL1A mediates fibroblast-like synoviocytes migration and Indian Hedgehog signaling pathway via TNFR2 in patients with rheumatoid arthritis 期刊论文 Mahmoud Al-Azab;Wei Jing;Ouyang Xunli;Abdalkhalig Elkhider;Williams Walana;Sun Xiaotong;Tang Yawei;Wang Bing;Li Xia
19 TL1A/TNFR2 Axis Enhances Immunoregulatory Effects of Bone Marrow Derived Mesenchymal Stem Cell by Indian Hedgehog Signaling Pathway 期刊论文 Mahmoud Al-Azab;Williams Walana;Wei Jing;Li Weiping;Tang Yawei;Wei Xiaoqing;Marwan Almoiliqy;Abdullah Shopit;Elrayah Eltahir Abbas;Salah Adlat;Mohammed Awsh;Xia Li;Bing Wang
20 IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes 期刊论文 Wang Bing;Ma Zijian;Wang Miaomiao;Sun Xiaotong;Tang Yawei;Li Ming;Zhang Yan;Li Fang;Li Xia
21 Clinical characteristics and risk factors of infection in patients with systemic lupus erythematosus: a systematic review and meta-analysis of observational studies 期刊论文 Yuan Qihang;Xing Xue;Lu Zhimin;Li Xia
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