基于Nurr1基因的帕金森病发病机制研究

81430021
2014
H0904.运动障碍性疾病
乐卫东
重点项目
教授
大连医科大学
320万元
TopIIβ;Jmjd3;Nurr1;α-突触核蛋白;帕金森病
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 阿尔茨海默病风险因素新发现及机制研究 奖励 乐卫东;李崧;董春波;魏敏;程诚;杨兆菲;李天白
2 中国杰出神经内科医师.学术成就奖 奖励 乐卫东
3 用于诊断帕金森病的联合标志物及检测试剂盒 专利 乐卫东
4 MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian 期刊论文 Mo Mingshu;Xiao Yousheng;Huang Shuxuan;Ceng Luan;Chen Xiang;Zhang Liming;Luo Qin;Xu pingyi
5 帕金森病中西医治疗 专著 乐卫东
6 Graphene oxide nanocolloids induce autophagy-lysosome dysfunction in mouse embryonic stem cells 期刊论文 Wei Min;Fu Zhenfa;Wang Che;Zheng Wei;Li Song;Le Weidong
7 线粒体自噬参与帕金森病发病机制的研究进展 期刊论文 王英;张强;乐卫东
8 Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline 期刊论文 Zhang Feng;Zhong Rujia;Li Song;Fu Zhenfa;Wang R;Wang T;Huang Zhili;Le Weidong
9 神经变性疾病的创新研究和应用 奖励 乐卫东;邓昊;陈晟;李崧;程诚;魏敏;杨兆菲;李天白
10 痴呆中西医治疗 专著 乐卫东;陈立典
11 《自噬-生物学与疾病(临床卷)》 专著 乐卫东
12 Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APP(swe)/PS1(dE9) Mice and Their Wild Type Littermates 期刊论文 Zhang Feng;Zhong Rujia;Qi Hongqian;Li Song;Cheng Cheng;Liu Xinyao;Liu Yufei;Le Weidong
13 Frontier in Neurology Research Beyond Neurodegenerative Diseases. 期刊论文 Le Weidong
14 Autophagy in neurodegenerative diseases: pathogenesis and therapy 期刊论文 Guo Fang;Liu Xinyao;Cai Huaibin;Le Weidong
15 《生物药物与临床应用》 专著 王佃亮;乐卫东
16 Elevated Plasma microRNA-105-5p Level in Patients With Idiopathic Parkinson's Disease: A Potential Disease Biomarker 期刊论文 Yang Zhaofei;Li Tanbai;Cui Yanhua;Li Song;Cheng Cheng;Shen Bairong;Le Weidong
17 辽宁省优秀科技工作者 奖励 乐卫东
18 miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs 期刊论文 Cui Yanhua;Li Ting;Yang Dehua;Li Song;Le Weidong
19 Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning 期刊论文 Wu Junbing;Kung Justin;Dong Jie;Chang Lisa;Xie Chengsong;Lin Da-Ting;Le Weidong;Cai Huaibin
20 Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update 期刊论文 Zhang Feng;Niu Long;Liu Yufei;Liu Xinyao;Li Song;Le Weidong
21 Nurr1-Based Therapies for Parkinson's Disease 期刊论文 Dong Jie;Li Song;Mo Jinglin;Cai Huaibin;Le Weidong
22 Biomarkers for Parkinson's Disease: How Good Are They? 期刊论文 Li Tianbai;Le Weidong
23 Dopamine Agonists Exert Nurr1‑inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease 期刊论文 Zhang Liming;Sun Congcong;Mo Mingshu;Cen Luan;Wei Lei;Luo Feifei;Liu Zhuolin;Le Weidong;Xu Pingyi
24 Current Pharmaceutical Treatments and Alternative Therapies of Parkinson’s Disease 期刊论文 Dong Jie;Cui Yanhua;Li Song;Le Weidong
25 Early pathogenic event of Alzheimer’s disease documented in iPSCs from patients with PSEN1 mutations 期刊论文 Yang Juan;Zhao Hanzhi;Ma Yu;Shi Guilai;Song Jian;Tang Yu;Zhang Xiaohui;Jin Ying;Le Weidong
26 Glioblastoma: targeting the autophagy in tumorigenesis 期刊论文 Yang Kang;Niu Long;Bai Yijing;Le Weidong
27 Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms 期刊论文 Wei Min;Li Song;Le Weidong
28 Milestones of Parkinson's Disease Research: 200 Years of History and Beyond 期刊论文 Li Song;Le Weidong
29 Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model 期刊论文 Zhang Jingjing;Zhou Qinming;Chen Sheng;Le Weidong
30 Roles of VMP1 in Autophagy and ER–Membrane Contact: Potential Implications in Neurodegenerative Disorders 期刊论文 Wang Panpan;Kou Daqing;Le Weidong
31 一种帕金森病诊断试剂盒及其应用 专利 乐卫东
32 Pathological Impacts of Chronic Hypoxia on Alzheimer's Disease. 期刊论文 Zhang Feng;Niu Long;Li Song;Le Weidong
33 Biomarker Discovery in Parkinson's Disease: Present Challenges and Future Opportunities 期刊论文 Li Song;Le Weidong
34 Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer’s Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model 期刊论文 Liu Hui;Qiu Hongyan;Xiao Qian;Le Weidong
35 Chronic hypoxia facilitates Alzheimer’s disease through demethylation of g-secretase by downregulating DNA methyltransferase 3b 期刊论文 Liu Hui;Qiu Hongyan;Yang Juan;Ni Jun;Le Weidong
36 Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction 期刊论文 Zhang Limin;Cen Luan;Qu Shaogang;Wei Lei;Mo Mingshu;Feng Junmin;Yang Xinling;Xu Pingyi
37 A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy 期刊论文 Guo Fang;He Xibiao;Le Weidong
38 Alterations of NURR1 and Cytokines in the Peripheral Blood Mononuclear Cells: Combined Biomarkers for Parkinson's Disease 期刊论文 Li Tianbai;Yang Zhaofei;Li Song;Cheng Cheng;Shen Bairong;Le Weidong
39 Recent advances and perspectives of metabolomiscs-based Investigations in Parkinson’s disease 期刊论文 Shao Yaping;Le Weidong
40 Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions 期刊论文 Li Song;Dong Jie;Cheng Cheng;Le Weidong
41 Protective Microglia and Their Regulation in Parkinson's Disease 期刊论文 Le Weidong;Wu Junjiao;Tang Yu
42 Nurr1Cd11bcre conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons 期刊论文 Dong Jie;Liu Xinyao;Wang yuanyuan;Cai huaibin;Le Weidong
43 Recent advances in microfluidic models for cancer metastasis research 期刊论文 Xu Hui;Liu Xinyao;Le Weidong
44 Alteration of Metabolic Profile and Potential Biomarkers in the Plasma of Alzheimer’s Disease 期刊论文 Shao Yaping;Ouyang Yang;Li Tianbai;Liu Xinyao;Xu Xiaojiao;Li Song;Xu Guowang;Le Weidong
45 An insight review of autophagy biology and neurodegenerative diseases:machinery, mechanisms and regulation 期刊论文 Li Song;Le Weidong
46 Induced pluripotent stem cells in Alzheimer's disease: applications for disease modeling and cell-replacement therapy 期刊论文 Yang Juan;Li Song;He Xi Biao;Cheng Cheng;Le Weidong
47 帕金森病患者尸检迷走神经病理和肠道神经炎症分析 期刊论文 杨兆菲;孙雷;寇大庆;李天白;孙志刚;乐卫东
48 Fingerprint analysis of Huolingshengji Formula and its neuroprotective efects in SOD1G93A mouse model of amyotrophic lateral sclerosis 期刊论文 Zhou Qinming;Wang Youjie;Zhang Jingjing;Shao Yaping;Li Song;Wang Yuan;Cai Huaibin;Feng Yi;Le Weidong
49 α-Synuclein negatively regulates Nurr1 expression through NF-κB- related mechanism 期刊论文 Jia Congcong;Qi Hongqian;Cheng Cheng;Wu Xuefei;Yang Zhaofei;Cai Huaibin;Chen Sheng;Le Weidong
50 最佳组稿奖、最佳审稿奖和最佳论文奖 奖励 乐卫东
51 The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms 期刊论文 Zhang Feng;Zhong Rujia;Li Song;Chang Raymond Chuen Chung;Le Weidong
52 Can Biomarkers Help the Early Diagnosis of Parkinson's Disease? 期刊论文 Le Weidong;Dong Jie;Li Song;Korczyn Amos D
53 Progress in Diagnosing Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke‑like Episodes 期刊论文 Wang Yingxin;Le Weidong
54 Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson’s Disease 期刊论文 Wang Ying;Yang Zhaofei;Le Weidong
55 Genetic analysis of NUS1 in Chinese patients with Parkinson's disease 期刊论文 Chen Xiang;Xiao Yousheng;Zhou Miaomiao;Lin Yuwan;Guo Wenyuan;Huang Shuxuan;Zhu Xiaoqin;Xu Pingyi
56 神经退行性疾病的创新研究和临床应用 奖励 乐卫东;邓昊;张晓洁;陈晟;李崧;杜芸兰;虢毅;程诚;张炳蔚
57 Gold nanoparticles enhance the differentiation of embryonic stem cells into dopaminergic neurons via mTOR/p70S6K pathway 期刊论文 Wei Min;Li Song;Yang Zhaofei;Zheng Wei;Le Weidong
58 Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1G93A transgenic mouse model 期刊论文 Shang Hai‐Yan;Zhang Jing‐Jing;Fu Zhen‐Fa;Liu Yu‐Fei;Li Song;Chen Sheng;Le Wei‐Dong
59 Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model 期刊论文 Zhang Jingjing;Liu Yufei;Liu Xinyao;Li Song;Cheng Cheng;Chen Sheng;Le Weidong
60 编委杰出贡献奖 奖励 乐卫东
61 n-butylidenephthalide treatment prolongs life span and attenuates motor neuron loss in SOD1G93A mouse model of amyotrophic lateral sclerosis 期刊论文 Zhou Qinming;Zhang Jingjing;Li Song;Chen Sheng;Le Weidong
62 A New VMAT-2 Inhibitor NBI-641449 in the Treatment of Huntington Disease 期刊论文 Chen Sheng;Zhang Xiaojie;Xie Wenjie;Qiu Hongyan;Liu Hui;Le Weidong
63 Association of LAG3 genetic variation with an increased risk of PD in Chinese female population 期刊论文 Guo Wenyuan;Zhou Miaomiao;Qiu Jiewen;Lin Yuwan;Chen Xiang;Huang Shuxuan;Mo Mingshu;Liu Hanqun;Peng Guoyou;Zhu Xiaoqin;Xu Pingyi
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