酸敏感离子通道功能与调控机理研究

30830035
2008
C0503.细胞感应与环境生物物理
徐天乐
重点项目
教授
上海交通大学
190万元
镇痛(antinociception);ion;组织酸化(tissue;channel);acidosis);敏感化(sensitization);酸敏感离子通道(acid-sensing;神经保护(neuroprotection)
2009-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation 期刊论文 Yang, Huaiyu|Yu, Ye|Li, Wei-Guang|Xu, Tian-Le|Jiang, Hualiang|
2 ASIC3 channels in multimodal sensory perception 期刊论文 Li W.-G.|Xu T.-L.|
3 Emerging approaches to probing ion channel structure and function 期刊论文 Wei-Guang Li|Tian-Le Xu Neuroscience Division|Department of Biochemistry and Molecular Cell Biol|Institute of Medical Sciences|Shanghai Jiao Tong University School of Medicine|Shanghai 200025|China|Wei-Guang Li,Tian-Le Xu Neuroscience Division,Depa|
4 Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism 期刊论文 Yang, Huaiyu|Yu, Ye|Li, Wei-Guang|Yu, Fang|Cao, Hui|Xu, Tian-Le|Jiang, Hualiang|
5 Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels 期刊论文 Yu, Ye|Li, Wei-Guang|Chen, Zhi|Cao, Hui|Yang, Huaiyu|Jiang, Hualiang|Xu, Tian-Le|
6 GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation 期刊论文 Gong, Neng|Fei, Jian|Xu, Tian-Le|Li, Yong|Cai, Guo-Qiang|Niu, Rui-Fang|Fang, Qi|Wu, Kun|Chen, Zhong|Lin, Long-Nian|Xu, Lin|
7 Highly Conserved Salt Bridge Stabilizes Rigid Signal Patch at Extracellular Loop Critical for Surface Expression of Acid-sensing Ion Channels 期刊论文 Yang, Yang|Yu, Ye|Cheng, Jin|Liu, Yan|Liu, Di-Shi|Wang, Jin|Zhu, Michael X.|Wang, Rui|Xu, Tian-Le|
8 Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis 期刊论文 Duan, Bo|Zhu, Michael X.|Xiong, Zhi-Gang|Xu, Tian-Le|Wang, Yi-Zhi|Yang, Tao|Chu, Xiang-Ping|Yu, Ye|Huang, Yu|Cao, Hui|Hansen, Jillian|Simon, Roger P.|
9 Nonproton ligand sensing domain is required for paradoxical stimulation of Acid-sensing Ion Channel 3 (ASIC3) channels by amiloride 期刊论文 Li, Wei-Guang|Yu, Ye|Huang, Chen|Cao, Hui|Xu, Tian-Le|
10 Acidosis, Acid-Sensing Ion Channels, and Neuronal Cell Death 期刊论文 Wang, Yi-Zhi|Xu, Tian-Le|
11 PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity 期刊论文 Duan B.|Liu D.-S.|Huang Y.|Zeng W.-Z.|Wang X.|Yu H.|Zhu M.X.|Chen Z.-Y.|Xu T.-L.|
12 Proton production, regulation and pathophysiological roles in the mammalian brain 期刊论文 Zeng, Wei-Zheng|Xu, Tian-Le|
13 A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel 期刊论文 Yu, Ye|Chen, Zhi|Li, Wei-Guang|Cao, Hui|Feng, En-Guang|Yu, Fang|Liu, Hong|Jiang, Hualiang|Xu, Tian-Le|
14 Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation 期刊论文 Xu, Tian-Le|
15 Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control 期刊论文 Xu, Tian-Le|Duan, Bo|
16 ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain 期刊论文 Li, Wei-Guang|Yu, Ye|Zhang, Zhu-Dan|Cao, Hui|Xu, Tian-Le|
17 Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice 期刊论文 Pan, Xiaoli|Xu, Zhiru|Dong, Wenxin|Qin, Yan|Fei, Guoqiang|Zhong, Chunjiu|Xu, Tian-Le|Gong, Neng|Zhao, Jing|Yu, Zhe|Gu, Fenghua|Chen, Jia|Sun, Xiaojing|Zhao, Lei|Yu, Meijing|
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