Bcl-2家族蛋白在慢性粒细胞白血病Bcr/Abl非依赖型耐药中的机制研究

81570129
2015
H0809.白血病
张志超
面上项目
教授
大连理工大学
45万元
慢性粒细胞白血病;Bcr/Abl非依赖耐药;BH3功能模拟物;磷酸化修饰;Bcl-2蛋白
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A novel turn-on fluorescent probe for selective sensing and imaging of glutathione in live cells and organisms 期刊论文 Zhang Xiaodong;Wang Ziqian;Guo Zongwei;He Nianzhe;Liu Peng;Xia Dasha;Yan Xiufen;Zhang Zhichao
2 线性短模体:介导蛋白质相互作用的新模块 期刊论文 刘璐;张志超
3 Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands 期刊论文 Wang Ziqian;He Nianzhe;Guo Zongwei;Niu Cuili;Song Ting;Guo Yafei;Cao Keke;Wang Anhui;Zhu Junjie;Zhang Xiaodong;Zhang Zhichao
4 Discovery of selective Mcl-1 inhibitors via structure-based design and structure-activity relationship analysis 期刊论文 He Nianzhe;Liu Peng;Wang Ziqian;Guo Zongwei;Yan Xinxin;Chen Hongbo;Zhang Zhichao
5 一类吖啶化合物及其应用 专利 张志超;李祥乾
6 苯并咪唑类化合物及其应用 专利 张志超;苏鹏辰
7 Affinity-based probe reveal Bim negatively regulates the chaperone functions of Hsp70, a non-Bcl-2 BH3 receptor 会议论文 Wang Ziqian;Zhang Zhichao;Song Ting;Guo Zongwei
8 Using CETSA assay and a mathematical model to reveal dual Bcl-2/Mcl-1 inhibition and on-target mechanism for ABT-199 and S1 期刊论文 Guo Zongwei;Song Ting;Xue Zuguang;Liu Peng;Zhang zhichao
9 Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination 期刊论文 Song Ting;Wang Ziqian;Ji Fangling;Feng Yingang;Fan Yudan;Chai Gaobo;Li Xiangqian;Li Zhiqiang;Zhang Zhichao
10 Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding 期刊论文 Song Ting;Chai Gaobo;Liu Yubo;Yu Xiaoyan;Wang Ziqian;Zhang Zhichao
11 Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like 期刊论文 Ziqian Wang;Ting Song;Yingang Feng;Zongwei Guo;Yudan Fan;Wenjie Xu;Lu Liu;Anhui Wang;Zhichao Wang
12 Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxylic Acids as Selective Mcl-1 Inhibitors 期刊论文 Wang Ziqian;Xu Wenjie;Song Ting;Guo Zongwei;Liu Lu;Fan Yudan;Wang Anhui;Zhang Zhichao
13 Expression and Solution NMR Study of Multi-site Phosphomimetic Mutant BCL-2 Protein 期刊论文 Song Ting;Cao Keke;Fan Yu dan;Zhang Zhichao;Guo Zong W;Zhang Min H;Liu Peng
14 一类1,5-二苯基吡唑-3-羧酸类化合物及其应用 专利 张志超;王紫千;宋婷
15 Systems analysis of phosphorylation-regulated Bcl-2 interactions establishes a model to reconcile the controversy over the significance of Bcl-2 phosphorylation 期刊论文 Song Ting;Wang Peiran;Yu Xiaoyan;Wang Anhui;Chai Gaobo;Fan Yudan;Zhang Zhichao
16 Identification of the Apoptosis and Autophagy Bi-functional Proteins. 期刊论文 Peiran Wang;Zhichao Zhang
17 Identification of JNK1 as a predicting biomarker for ABT-199 and paclitaxel combination treatment 期刊论文 Ting Song;Minhang Zhang;Peng Liu;Zhenyu Xue;Yudan Fan;Zhichao Zhang
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