人精原干细胞自我更新与分化为精子细胞的分子机理研究

31230048
2012
C1206.生殖细胞及性别决定
何祖平
重点项目
教授
上海交通大学
280万元
男性生殖细胞;小分子RNA和信号转导;自我更新;分化;人精原干细胞
2013-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2 期刊论文 Liangyu Zhao;Zijue Zhu;Chencheng Yao;Yuhua Huang;Erlei Zhi;Huixing Chen;Ruhui Tian;Peng Li;Qingqing Yuan;Yunjing Xue;Zhong Wan;Chao Yang;Yuehua Gong;Zuping He;Zheng Li
2 Fractionation of human spermatogenic cells using STAPUT gravity sedimentation and their miRNA profiling 期刊论文 Yun Liu;Minghui Niu;Chencheng Yao;Yanan Hai;Qingqing Yuan;Yang Liu;Ying Guo;Zheng Li;Zuping He
3 Acetylcholine Acts on Androgen Receptor to Promote the Migration and Invasion but Inhibit the Apoptosis of Human Hepatocarcinoma 期刊论文 Huizhen Nie;Qingzhen Cao;Lei Zhu;Yuehua Gong;Jianren Gu;Zuping He
4 Plasticity of male germline stem cells and their applications in reproductive and regenerative medicine 期刊论文 Zheng Chen;Zheng Li;Zuping He
5 The Function and Regulation of BMP6 in Various Kinds of Stem Cells 期刊论文 Ruinan Shen;Ruobing Jia;Wenjie Liu;Qisheng Lin;Yanan Hai;Zuping He
6 Generation of male differentiated germ cells from various types of stem cells 期刊论文 Jingmei Hou;Shi Yang;Hao Yang;Yang Liu;Yun Liu;Yanan Hai;Zheng Chen;Ying Guo;Yuehua Gong;Wei-Qiang Gao;Zheng Li;Zuping He
7 NODAL secreted by male germ cells regulates the proliferation and function of humanSertoli cells 期刊论文 Ru-Hui Tian;Shi Yang;Zi-Jue Zhu;Jun-Long Wang;Yun Liu;Chencheng Yao;Meng Ma;Ying Guo;Zuping He;Zheng Li
8 一种人精原干细胞体外分化为功能精子细胞的三维诱导方法 专利 何祖平;孙敏;袁青青;牛明辉;王洪;文丽平;付红勇;周帆;李铮
9 Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation 期刊论文 Ying Guo;Yanan Hai;Chencheng Yao;Zheng Chen;Jingmei Hou;Zheng Li;Zuping He
10 Transdifferentiation of human male germline stem cells to hepatocytes in vivo via the transplantation under renal capsules 期刊论文 Zheng Chen;Minghui Niu;Min Sun;Qingqing Yuan;Chengchen Yao;Jingmei Hou;Hong Wang;Liping Wen;Hongyong Fu;Zheng Li;Zuping He
11 Sertoli cells from non-obstructive azoospermia and obstructive azoospermia patients show distinct morphology, Raman spectrum and biochemical phenotype 期刊论文 Meng Ma;Shi Yang;Zhenzhen Zhang;Peng Li;Yuehua Gong;Linhong Liu;Yong Zhu;Ruhui Tian;Yufei Liu;Xiaobo Wang;Feng Liu;Lin He;Yang Liu;Hao Yang;Zheng Li;Zuping He
12 Characterization, isolation and culture of mouse and human spermatogonial stem cells 期刊论文 Ying Guo;Yanan Hai;Yuehua Gong;Zheng Li;Zuping He
13 Efficient Generation of Functional Haploid Spermatids From Human Germline Stem Cells by Three-Dimension Induced System 期刊论文 Min Sun;Qingqing Yuan;Minghui Niu;Hong Wang;Liping Wen;Chencheng Yao;Jingmei Hou;Zheng Chen;Hongyong Fu;Fan Zhou;Chong Li;Shaorong Gao;Wei-Qiang Gao;Zheng Li;Zuping He
14 Differentiation of induced pluripotent stem cells into male germ cells in vitro through embryoid body formation and retinoic acid or testosterone induction 期刊论文 Peng Li;Hongliang Hu;Shi Yang;Ruhui Tian;Zhenzhen Zhang;Wei Zhang;Meng Ma;Yong Zhu;Xizhi Guo;Yiran Huang;Zuping He;Zheng Li
15 Establishment and applications of male germ cell and Sertoli cell lines 期刊论文 Hong Wang;Liping Wen;Qingqing Yuan;Min Sun;Minghui Niu;Zuping He
16 Raman spectroscopy as an ex vivo noninvasive approach to distinguish complete and incomplete spermatogenesis within human seminiferous tubules 期刊论文 Yufei Liu;Yong Zhu;Ling Di;Charles Osterberg;Feng Liu;Lin He;Hongliang Hu;Yiran Huang;Philip S. Li;Zheng Li
17 Isolation, Identification, distinct global microRNA profiling and novel targets among human spermatogonia, pachytene spermatocytes and round spermatids 奖励 何祖平;刘云
18 MicroRNAs and DNA methylation as epigenetic regulators of mitosis, meiosis and spermiogenesis 期刊论文 Chencheng Yao;Yun Liu;Min Sun;Minghui Niu;Qingqing Yuan;Yanan Hai;Ying Guo;Zheng Chen;Jingmei Hou;Yang Liu;Zuping He
19 Establishment and Characterization of Human Germline Stem Cell Line with Unlimited Proliferation Potentials and no Tumor Formation 期刊论文 Jingmei Hou;Minghui Niu;Linhong Liu;Zijue Zhu;Xiaobo Wang;Min Sun;Qingqing Yuan;Wenxian Zeng;Yang Liu;Zheng Li;Zuping He
20 Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E 期刊论文 Zhenzhen Zhang;Yuehua Gong;Ying Guo;Yanan Hai;Hao Yang;Shi Yang;Yang Liu;Meng Ma;Linhong Liu;Zheng Li;Wei-Qiang Gao;Zuping He
21 BMP4 promotes mouse iPS cell differentiation to male germ cells via Smad1/5, Gata4, Id1 and Id2 期刊论文 Shi Yang;Qingqing Yuan;Minghui Niu;Jingmei Hou;Min Sun;Zheng Li;Zuping He
22 Nodal Promotes the Self-renewal of Human Colon Cancer Stem Cells via an Autocrine Manner through Smad2/3 Signaling Pathway 期刊论文 Yuehua Gong;Ying Guo;Yanan Hai;Hao Yang;Yang Liu;Shi Yang;Zhenzhen Zhang;Meng Ma;Linhong Liu;Zheng Li;Zuping He
23 MiRNA-133b promotes the proliferation of human Sertoli cells throughtargeting GLI3 期刊论文 Chencheng Yao;Min Sun;Qingqing Yuan;Minghui Niu;Zheng Chen;Jingmei Hou;Hong Wang;Liping Wen;Yun Liu;Zheng Li;Zuping He
24 The roles and regulation of Sertoli cells in fate determinations of spermatogonial stem cells and spermatogenesis 期刊论文 Yanan Hai;Jingmei Hou;Yun Liu;Yang Liu;Hao Yang;Zheng Li;Zuping He
25 Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of cryptorchid patients 期刊论文 Shi Yang;Ping Ping;Meng Ma;Peng Li;Ruhui Tian;Hao Yang;Yang Liu;Yuehua Gong;Zhenzhen Zhang;Zheng Li;Zuping He
26 Generation and characteristics of human Sertoli cell line immortalized by overexpression of human telomerase 期刊论文 Liping Wen;Qingqing Yuan;Min Sun;Minghui Niu;Hong Wang;Hongyong Fu;Fan Zhou;Chencheng Yao;Xiaobo Wang;Zheng Li;Zuping He
27 MiRNA-20 and MiRNA-106a Regulate Spermatogonial Stem Cell Renewal at the Post-Transcriptional Level via Targeting STAT3 and Ccnd1 期刊论文 Zuping He;Jiji Jiang;Maria Kokkinaki;Lin Tang;Wenxian Zeng;Ian Gallicano;Ina Dobrinski;Martin Dym
28 Expansion and longterm culture of human spermatogonial stem cells via the SMAD3 and AKT pathways 期刊论文 Ying Guo;Linhong Liu;Yanan Hai;Chencheng Yao;Zheng Chen;Jingmei Hou;Zheng Li;Zuping He
29 精子细胞 (生成,成熟,受精,再生) 专著 李铮;陈荪红;何祖平
30 Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients 期刊论文 Chencheng Yao;Qingqing Yuan;Minghui Niu;Hongyong Fu;Fan Zhou;Wenhui Zhang;Liping Wen;Ligang Wu;Zheng Li;Zuping He
31 一种分离人精原干细胞的方法 专利 何祖平;刘阳;刘建芳;张桢珍;李铮
32 The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice 期刊论文 An J;Zhang X;Qin J;Wan Y;Hu Y;Liu T;Li J;Dong W;Du E;Pan C;Wenxian Zeng
33 BMP6 regulates proliferation and apoptosis of human Sertoli cells via Smad2/3 and cyclin D1 pathway and DACH1 and TFAP2A activation 期刊论文 Hong Wang;Qingqing Yuan;Min Sun;Minghui Niu;Liping Wen;Hongyong Fu;Fan Zhou;Zheng Chen;Chencheng Yao;Jingmei Hou;Ruinan Shen;Qisheng Lin;Wenjie Liu;Ruobing Jia;Zheng Li;Zuping He
34 Efficient conversion of mouse spermatogonial stem cells to phenotypic and functional dopaminergic neurons via PI3K/Akt and P21/Smurf2/Nolz1 pathway 期刊论文 Hao Yang;Yang Liu;Yanan Hai;Yuehua Gong;Ying Guo;Shi Yang;Zhenzhen Zhang;Linhong Liu;Zheng Li;Wei-Qiang Gao;Zuping He
35 Dynamics of the Transcriptome during Human Spermatogenesis: Predicting the Potential Key Genes Regulating Male Gametes Generation 期刊论文 Zijue Zhu;Chong Li;Shi Yang;Ruhui Tian;Junlong Wang;Qingqing Yuan;Hui Dong;Zuping He;Shengyue Wang;Zheng Li
36 Generation of functional hepatocytes fromhuman spermatogonial stem cells 期刊论文 Zheng Chen;Min Sun;Qingqing Yuan;Minghui Niu;Chencheng Yao;Jingmei Hou;Hong Wang;Liping Wen;Yun Liu;Zheng Li;Zuping He
37 Transcriptional regulation of P63 on the apoptosis of male germ cells and three stages of spermatogenesis in mice 期刊论文 Hong Wang;Qingqing Yuan;Minghui Niu;Wenhui Zhang;Liping Wen;Hongyong Fu;Fan Zhou;Zuping He
38 Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects 期刊论文 Erlei Zhi;Peng Li;Huixing Chen;Peng Xu;Xiaobin Zhu;Zijue Zhu;Zuping He;Zheng Li
39 BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia 期刊论文 Yanan Hai;Min Sun;Minghui Niu;Qingqing Yuan;Zheng Li;Zuping He
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