蛋白质胆固醇动态修饰的调控机制、化学干预和功能研究
91753204
2017
B0702.生物分子的化学生物学
宋保亮
重大研究计划
教授
武汉大学
300万元
肿瘤;胆固醇;Smo;探针;hedgehog
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol | 期刊论文 | Jiang Shi-You;Li Hui;Tang Jing-Jie;Wang Jie;Luo Jie;Liu Bing;Wang Jin-Kai;Shi Xiong-Jie;Cui Hai-Wei;Tang Jie;Yang Fan;Qi Wei;Qiu Wen-Wei;Song Bao-Liang |
| 2 | Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2 | 期刊论文 | Zhou Zhang-Sen;Li Mei-Xin;Liu Jie;Jiao Hengwu;Xia Jing-Ming;Shi Xiong-Jie;Zhao Huabin;Chu Liping;Liu Jingrong;Qi Wei;Luo Jie;Song Bao-Liang |
| 3 | 一种三环二萜类似物及其合成和应用 | 专利 | 仇文卫;宋保亮;何丽明;刘源彬 |
| 4 | Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S] | 期刊论文 | Chen Liang;Ma Mei-Yan;Sun Ming;Jiang Lu-Yi;Zhao Xue-Tong;Fang Xian-Xiu;Lam Sin Man;Shui Guang-Hou;Luo Jie;Shi Xiong-Jie;Song Bao-Liang |
| 5 | Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase | 期刊论文 | Jiang Shi-You;Tang Jing-Jie;Xiao Xu;Qi Wei;Wu Suqian;Jiang Chao;Hong Jiaxu;Xu Jianjiang;Song Bao-Liang;Luo Jie |
| 6 | The 3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase EBP inhibits cholesterylation of Smoothened. | 期刊论文 | Qiu Zhi-Ping;Hu Ao;Song Bao-Liang |
| 7 | Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate. | 期刊论文 | Hu Ao;Zhang Jing-Zan;Wang Jie;Li Chen-Chen;Yuan Meng;Deng Gang;Lin Zi-Cun;Qiu Zhi-Ping;Liu Hu-Yue;Wang Xian-Wei;Wei Peng-Cheng;He Xiao;Zhao Xiaolu;Qiu Wen-Wei;Song Bao-Liang |
| 8 | The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling | 期刊论文 | Hu Ao;Song Bao-Liang |
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