修饰核酸的化学标记和检测技术研发
91753201
2017
B0701.生物体系分子探针
周翔
重大研究计划
教授
武汉大学
300万元
单碱基分辨率的测序;修饰核酸标记;分子探针;修饰核酸识别
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes | 期刊论文 | Yang Ying;Zeng Chang;Lu Xingyu;Song Yanqun;Nie Ji;Ran Ruoxi;Zhang Zhou;He Chuan;Zhang Wei;Liu Song-Mei |
| 2 | Gene specific-loci quantitative and single-base resolution analysis of 5-formylcytosine by compound-mediated polymerase chain reaction | 期刊论文 | Wang Yafen;Liu Chaoxing;Zhang Xiong;Yang Wei;Wu Fan;Zou Guangrong;Weng Xiaocheng;Zhou Xiang |
| 3 | Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication | 期刊论文 | Bian Wen-Xiu;Xie Yan;Wang Xiao-Ning;Xu Guo-Hua;Fu Bo-Shi;Li Shu;Long Gang;Zhou Xiang;Zhang Xiao-Lian |
| 4 | Pt(IV) Prodrugs Designed to Embed in Nanotubes of a Polysaccharide for Drug Delivery | 期刊论文 | Chen Kun;Cai Liqin;Yang Shixi;Peng Shuang;Huang Jinguo;Xu Jinglei;Lu Ziang;Xu Xiaojuan;Fu Boshi;Zhang Lina;Zhou Xiang |
| 5 | 5-Formyluracil as a cornerstone for aluminum detection in vitro and in vivo: a more natural and sustainable strategy | 期刊论文 | Zou Guangrong;Liu Chaoxing;Cong Chen;Fang Zhentian;Yang Wei;Luo Xiaomeng;Jia Shaokang;Wu Fan;Zhou Xiang |
| 6 | Photostable lysosomal imaging of living cell with hyperspectral stimulated Raman scattering microscopy using a probe based on bisarylbutadiyne | 期刊论文 | Ding Cong;Chen Yage;Li Haozheng;Wang Bingyao;Wei Qi;Tang Huajun;Jia Shaokang;He Zhiyong;Wang Ping;Zhou Xiang |
| 7 | Ligation-Based qPCR-Amplification Assay for Radiolabel-Free Detection of ATP and NAD(+) with High Selectivity and Sensitivity | 期刊论文 | Zhang Xiong;Wang Yafen;Zhou Xiang |
| 8 | Efficient Separation of Nucleic Acids with Different Secondary Structures by Metal-Organic Frameworks | 期刊论文 | Peng Shuang;Bie Binglin;Jia Hongnan;Tang Heng;Zhang Xiong;Sun Yuqing;Wei Qi;Wu Fan;Yuan Yushu;Deng Hexiang;Zhou Xiang |
| 9 | Sodium Sulfite-Mediated s(4)U Conversion for m(6)A Profiling of Nascent Transcriptome-Wide RNA | 期刊论文 | Wei Qi;Han Shaoqing;Chen Yuqi;Zhou Xiang |
| 10 | Multiplexed microRNA Detection Using Metal–Organic Framework for Signal Output | 期刊论文 | Shuang Peng;Min Liu;Binglin Bie;Yajun Zhang;Heng Tang;Yuqing Sun;Xiang Zhou |
| 11 | Assay for TET1 activity and its inhibitors screening with signal amplification by both nanoparticles and Ru(III) redox recycling | 期刊论文 | Cheng Ying;Tang Jing;Chen Xue;Wang Fang;Chen Zilin |
| 12 | Precise Antibody -Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution | 期刊论文 | Hong Tingting;Yuan Yushu;Chen Zonggui;Xi Kun;Wang Tianlu;Xie Yalun;He Zhiyong;Su Haomiao;Zhou Yu;Tan Zhi-Jie;Weng Xiaocheng;Zhou Xiang |
| 13 | Enantioselective Diels-Alder reactions with left-handed G-quadruplex DNA-based catalysts | 期刊论文 | Chen Kun;He Zhiyong;Xiong Wei;Wang Chun-Jiang;Zhou Xiang |
| 14 | Highly Selective 5-Formyluracil Labeling and Genome-wide Mapping Using (2-Benzimidazolyl)Acetonitrile Probe | 期刊论文 | Wang Yafen;Liu Chaoxing;Wu Fan;Zhang Xiong;Liu Sheng;Chen Zonggui;Zeng Weiwu;Yang Wei;Zhang Xiaolian;Zhou Yu;Weng Xiaocheng;Wu Zhiguo;Zhou Xiang |
| 15 | Sequencing 5-Formyluracil in Genomic DNA at Single-Base Resolution | 期刊论文 | Yang Wei;Han Shaoqing;Zhang Xiong;Wang Yafen;Zou Guangrong;Liu Chaoxing;Xu Muxin;Zhou Xiang |
| 16 | Photocaged probes for spatiotemporal imaging | 期刊论文 | Zou Guangrong;Liu Chaoxing;Fang Zhentian;Jia Shaokang;Yang Wei;Zhang Xiong;Chen Mingkai;Tian Tian;Weng Xiaocheng;Zhou Xiang |
| 17 | Photoactive G-Quadruplex Ligand Identifies Multiple G-Quadruplex-Related Proteins with Extensive Sequence Tolerance in the Cellular Environment | 期刊论文 | Su Haomiao;Xu Jinglei;Chen Yuqi;Wang Qi;Lu Ziang;Chen Yage;Chen Kun;Han Shaoqing;Fang Zhentian;Wang Ping;Yuan Bi-Feng;Zhou Xiang |
| 18 | Acrylonitrile-Mediated Nascent RNA Sequencing for Transcriptome-Wide Profiling of Cellular RNA Dynamics | 期刊论文 | Chen Yuqi;Wu Fan;Chen Zonggui;He Zhiyong;Wei Qi;Zeng Weiwu;Chen Kun;Xiao Feng;Yuan Yushu;Weng Xiaocheng;Zhou Yu;Zhou Xiang |
| 19 | Link Between m6A Modification and Cancers | 期刊论文 | Zhen-Xian Liu;Li-Man Li;Hui-Lung Sun;Song-Mei Liu |
| 20 | Fluorescence assay based on the thioflavin T-induced conformation switch of G-quadruplexes for TET1 detection | 期刊论文 | Chen Xue;Cheng Ying;Wang Yafen;Tang Jing;Wang Fang;Chen Zilin |
| 21 | Bisulfite-free and quantitative detection of 5-formylcytosine in DNA through qPCR | 期刊论文 | Liu Jizhou;Yang Wei;Zhang Xiong;Wang Yafen;Zhou Xiang |
| 22 | The roles of microRNAs in epigenetic regulation | 期刊论文 | Yao Qian;Chen Yuqi;Zhou Xiang |
| 23 | A novel nucleic acid aptamer tag: a rapid fluorescence strategy using a self-constructing G-quadruplex from AGG trinucleotide repeats | 期刊论文 | Fu Boshi;Park Yoojin;Kim Ki Tae;Chen Kun;Zou Guangrong;Wei Qi;Peng Shuang;Chen Yuqi;Kim Byeang Hyean;Zhou Xiang |
| 24 | End-labeling-based electrochemical strategy for detection of adenine methylation in nucleic acid by differential pulse voltammetry | 期刊论文 | Yang Hongmei;Wang Yafen;Tang Jing;Wang Fang;Chen Zilin |
| 25 | High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis | 期刊论文 | Su Haomiao;Xu Jinglei;Wang Qi;Wang Fuan;Zhou Xiang |
| 26 | Correction to An Ultrasensitive Diagnostic Biochip Based on Biomimetic Periodic Nanostructure-Assisted Rolling Circle Amplification | 期刊论文 | Qian Yao;Yingqian Wang;Jie Wang;Shaomin Chen;Haoyang Liu;Zhuoran Jiang;Xiaoe Zhang;Songmei Liu;Quan Yuan;Xiang Zhou |
| 27 | One-pot fluorescent assay for sensitive detection of APOBEC3A activity | 期刊论文 | Wang Bingyao;Zhang Xiong;Wang Yafen;Chen Kun;Wang Fang;Weng Xiaocheng;Zhou Xiang |
| 28 | Chemical methods and advanced sequencing technologies for deciphering mRNA modifications | 期刊论文 | Wang Yafen;Zhang Xiong;Liu Hui;Zhou Xiang |
| 29 | Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs | 期刊论文 | Yuan Er-Feng;Yang Ying;Cheng Lin;Deng Xujing;Chen Shao-Min;Zhou Xin;Liu Song-Mei |
| 30 | TRADES: Targeted RNA Demethylation by SunTag System | 期刊论文 | Mo Jing;Chen Zonggui;Qin Shanshan;Li Shu;Liu Chuangang;Zhang Lu;Ran Ruoxi;Kong Ying;Wang Fang;Liu Songmei;Zhou Yu;Zhang Xiaolian;Weng Xiaocheng;Zhou Xiang |
| 31 | Glucose Is Involved in the Dynamic Regulation of m(6)A in Patients With Type 2 Diabetes | 期刊论文 | Yang Ying;Shen Fan;Huang Wei;Qin Shanshan;Huang Jing-Tao;Sergi Consolato;Yuan Bi-Feng;Liu Song-Mei |
| 32 | A m(6)A Sensing Method by Its Impact on the Stability of RNA Double Helix | 期刊论文 | Yang Shixi;Wu Fan;Peng Shuang;Wang Fang;Chen Yi;Yuan Yushu;Weng Xiaocheng;Zhou Xiang |
| 33 | An Ultrasensitive Diagnostic Biochip Based on Biomimetic Periodic Nanostructure-Assisted Rolling Circle Amplification | 期刊论文 | Yao Qian;Wang Yingqian;Wang Jie;Chen Shaomin;Liu Haoyang;Jiang Zhuoran;Zhang Xiaoe;Liu Songmei;Yuan Quan;Zhou Xiang |
| 34 | Selective Labeling Aldehydes in DNA | 期刊论文 | Liu Chaoxing;Luo Xiaomeng;Chen Yuqi;Wu Fan;Yang Wei;Wang Yafen;Zhang Xiong;Zou Guangrong;Zhou Xiang |
| 35 | Efficient Self-Assembled DNA Nanoparticles through Rolling Circle Amplification for siRNA Delivery in vitro | 期刊论文 | Yao Qian;Chen Yuqi;Wu Fan;Liu Chaoxing;Hong Tingting;Li Wei;Chen Yi;Zhou Xiang |
| 36 | Keth-seq for transcriptome-wide RNA structure mapping | 期刊论文 | Weng Xiaocheng;Gong Jing;Chen Yi;Wu Tong;Wang Fang;Yang Shixi;Yuan Yushu;Luo Guanzheng;Chen Kai;Hu Lulu;Ma Honghui;Wang Pingluan;Zhang Qiangfeng Cliff;Zhou Xiang;He Chuan |
| 37 | N-3-Kethoxal-Based Bioorthogonal Intracellular RNA Labeling | 期刊论文 | Huang Jinguo;Zhao Ruiqi;Mo Jing;Wang Fang;Weng Xiaocheng;Zhou Xiang |
| 38 | 4-Thiouridine-Enhanced Peroxidase-Generated Biotinylation of RNA | 期刊论文 | Huang Jinguo;Zhao Ruiqi;Qin Shanshan;Yang Shixi;Li Wei;Mo Jing;Wang Fang;Du Yuhao;Weng Xiaocheng;Zhou Xiang |
| 39 | Luminescence Sensing for Qualitative and Quantitative Detection of 5-Methylcytosine | 期刊论文 | Yuan Yushu;Hong Tinting;Chen Yi;Wang Yafen;Qiu Xueping;Zheng Fang;Weng Xiaocheng;Zhou Xiang |
| 40 | Light-Driven Activation of RNA-Guided Nucleic Acid Cleavage | 期刊论文 | Wang Shaoru;Wei Lai;Wang Jia-Qi;Ji Huimin;Xiong Wei;Liu Jian;Yin Ping;Tian Tian;Zhou Xiang |
| 41 | Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA | 期刊论文 | Wang Yafen;Zhang Xiong;Zou Guangrong;Peng Shuang;Liu Chaoxing;Zhou Xiang |
| 42 | Bisulfite-free, single base-resolution analysis of 5-hydroxymethylcytosine in genomic DNA by chemical-mediated mismatch | 期刊论文 | Wang Yafen;Zhang Xiong;Wu Fan;Chen Zonggui;Zhou Xiang |
| 43 | 5-Formyluracil as a Multifunctional Building Block in Biosensor Designs | 期刊论文 | Liu Chaoxing;Zou Guangrong;Peng Shuang;Wang Yafen;Yang Wei;Wu Fan;Jiang Zhuoran;Zhang Xiong;Zhou Xiang |
| 44 | 5-Formyluracil targeted biochemical reactions with proteins inhibit DNA replication, induce mutations and interference gene expression in living cells | 期刊论文 | Zou Guangrong;Zhang Kaiyuan;Yang Wei;Liu Chaoxing;Fang Zhentian;Zhou Xiang |
| 45 | Conditional control of RNA-guided nucleic acid cleavage and gene editing | 期刊论文 | Wang Shao-Ru;Wu Ling-Yu;Huang Hai-Yan;Xiong Wei;Liu Jian;Wei Lai;Yin Ping;Tian Tian;Zhou Xiang |
| 46 | Systematic investigation of bioorthogonal cellular DNA metabolic labeling in a photo-controlled manner | 期刊论文 | Jia Shaokang;Yang Shixi;Ji Huimin;Peng Shuang;Chen Kun;He Zhiyong;Zhou Xiang |
| 47 | Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells | 期刊论文 | Peng Shuang;Bie Binglin;Sun Yangzesheng;Liu Min;Cong Hengjiang;Zhou Wentao;Xia Yucong;Tang Heng;Deng Hexiang;Zhou Xiang |
| 48 | Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays | 期刊论文 | Wang Yafen;Liu Chaoxing;Yang Wei;Zou Guangrong;Zhang Xiong;Wu Fan;Yu Shuyi;Luo Xiaomeng;Zhou Xiang |
| 49 | Copper (II) synergistic AS1411 conjunction with chemical decaging reactions for selective fluorescence imaging and prodrug activation in living systems | 期刊论文 | Chen Kun;Zou Guangrong;Xiong Wei;He Zhiyong;Yan Shen;Qin Shanshan;Wang Qi;Cong Hengjiang;Wang Chun-Jiang;Zhou Xiang |
| 50 | Selective Chemical Labeling and Sequencing of 5-Carboxylcytosine in DNA at Single-Base Resolution | 期刊论文 | Xie Yalun;Wang Yafen;He Zhiyong;Yang Wei;Fu Boshi;Zou Guangrong;Zhang Xiong;Huang Jinguo;Zhou Xiang |
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