化学小分子探针对染色体端粒DNA结构、生物学活性及相关信号转导的干预和影响
90813031
2008
B0702.生物分子的化学生物学
周翔
重大研究计划
教授
武汉大学
270万元
四链体核酸;端粒核酸;信号传导;小分子探针;端粒酶
2009-01-01到2012-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | High fluorescence selectivity and visual detection of G-quadruplex structures by a novel dinuclear ruthenium complex | 期刊论文 | Xu, Liang|Xu, Liang|Zhang, Dan|Zhang, Dan|Huang, Jing|Huang, Jing|Deng, Minggang|Deng, Minggang|Zhang, Ming|Zhang, Ming|Zhou, Xiang|Zhou, Xiang| |
| 2 | Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions | 期刊论文 | Xing, Xiwen|Xing, Xiwen|Wang, Xiaoling|Wang, Xiaoling|Xu, Liang|Xu, Liang|Tai, Yang|Tai, Yang|Dai, Luyang|Dai, Luyang|Zheng, Xiaolong|Zheng, Xiaolong|Mao, Wuxiang|Mao, Wuxiang|Xu, Xiaowei|Xu, Xiaowei|Zhou, Xiang|Zhou, Xiang| |
| 3 | Reaction-Based Two-Photon Fluorescent Probe for Turn-On Mercury(II) Sensing and Imaging in Live Cells | 期刊论文 | Huang, Rong|Huang, Rong|Zheng, Xiaolong|Zheng, Xiaolong|Wang, Changcheng|Wang, Changcheng|Wu, Renyi|Wu, Renyi|Yan, Shengyong|Yan, Shengyong|Yuan, Jiaqi|Yuan, Jiaqi|Weng, Xiaocheng|Weng, Xiaocheng|Zhou, Xiang|Zhou, Xiang| |
| 4 | Simultaneously sensitive detection of multiple miRNAs based on a strand displacement amplification | 期刊论文 | Tian, Tian|Tian, Tian|Meyers, Craig|Meyers, Craig|Zhou, Xiang|Zhou, Xiang|Xiao, Heng|Xiao, Heng|Zhang, Xiaolian|Zhang, Xiaolian|Peng, Shuang|Peng, Shuang|Zhang, Xiaoe|Zhang, Xiaoe|Guo, Shan|Guo, Shan|Wang, Shaoru|Wang, Shaoru|Liu, Songmei|Liu, Songmei|Zho |
| 5 | Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent | 期刊论文 | Zhang, Zhi|He, Rui|Yan, Kun|Guo, Qian-ni|Lu, Yun-guo|Wang, Xu-xia|Lei, Hao|Li, Zao-ying| |
| 6 | Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA | 期刊论文 | Du, Yuhao|Weng, Xiaocheng|Huang, Jing|Zhang, Dan|Ma, Heng|Chen, Dong|Zhou, Xiang|Constant, Jean-Francois| |
| 7 | Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells | 期刊论文 | Feng Wang|Ming-liang Tang|Zhi-xiong Zeng|Ren-yi Wu|Yong Xue|Yu-hua Hao|Dai-Wen Pang|Yong Zhao|Zheng Tan| |
| 8 | Ag+ and cysteine detection by Ag+-guanine interaction based on graphene oxide and G-quadruplex DNA | 期刊论文 | Liu, Lin|Liu, Lin|Liu, Wenting|Liu, Wenting|Hong, Tingting|Hong, Tingting|Weng, Xiaocheng|Weng, Xiaocheng|Zhai, Qianqian|Zhai, Qianqian|Zhou, Xiang|Zhou, Xiang| |
| 9 | A novel class of Cd(II), Hg(II) turn-on and Cu(II), Zn(II) turn-off Schiff base fluorescent probes | 期刊论文 | Hu, Yuan|Li, Qian-qian|Li, Hua|Guo, Qian-ni|Lu, Yun-guo|Li, Zao-ying| |
| 10 | Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change | 期刊论文 | Huang, Rong|Huang, Rong|Yan, Shengyong|Yan, Shengyong|Zheng, Xiaolong|Zheng, Xiaolong|Luo, Fengling|Luo, Fengling|Deng, Minggang|Deng, Minggang|Fu, Boshi|Fu, Boshi|Xiao, Yijie|Xiao, Yijie|Zhao, Xi|Zhao, Xi|Zhou, Xiang|Zhou, Xiang| |
| 11 | Folding Equilibrium Constants of Telomere G-Quadruplexes in Free State or Associated with Proteins Determined by Isothermal Differential Hybridization | 期刊论文 | Wang, Quan|Ma, Li|Hao, Yu-hua|Tan, Zheng| |
| 12 | Aptamer-based turn-on fluorescent four-branched quaternary ammonium pyrazine probe for selective thrombin detection | 期刊论文 | Yan, Shengyong|Yan, Shengyong|Huang, Rong|Huang, Rong|Zhou, Yangyang|Zhou, Yangyang|Zhang, Ming|Zhang, Ming|Deng, Minggang|Deng, Minggang|Wang, Xiaolin|Wang, Xiaolin|Weng, Xiaocheng|Weng, Xiaocheng|Zhou, Xiang|Zhou, Xiang| |
| 13 | Promoting the formation of tetramolecular G-quadruplexes under freezing condition | 期刊论文 | Zhai, Qianqian|Zhai, Qianqian|Deng, Minggang|Deng, Minggang|Xu, Liang|Xu, Liang|Zhang, Xiaolian|Zhang, Xiaolian|Zhou, Xiang|Zhou, Xiang| |
| 14 | 小分子对四链核酸结构和功能调控 | 会议论文 | 周翔| |
| 15 | 核酸甲基化检测方法进展 | 期刊论文 | 田沺|王少儒|吴建国|周翔| |
| 16 | Human telomeric G-quadruplexes undergo dynamic conversion in a molecular crowding environment | 期刊论文 | Xu, Liang|Xu, Liang|Feng, Shuo|Feng, Shuo|Zhou, Xiang|Zhou, Xiang| |
| 17 | Specific Recognition of DNA by Small Molecules | 期刊论文 | Du, Y. H.|Du, Y. H.|Huang, J.|Huang, J.|Weng, X. C.|Weng, X. C.|Zhou, X.|Zhou, X.| |
| 18 | The Sensitive and Selective Optical Detection of Mercury(II) Ions by Using a Phosphorothioate DNAzyme Strategy | 期刊论文 | Zhang, Dan|Deng, Minggang|Xu, Liang|Zhou, Yangyang|Yuwen, Jing|Zhou, Xiang| |
| 19 | G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase | 期刊论文 | Wang, Quan|Liu, Jia-quan|Chen, Zhao|Zheng, Ke-wei|Chen, Chang-yue|Hao, Yu-hua|Tan, Zheng| |
| 20 | Conformational Switching of G-Quadruplex DNA by Photoregulation | 期刊论文 | Wang, Xiaolin|Wang, Xiaolin|Huang, Jing|Huang, Jing|Zhou, Yangyang|Zhou, Yangyang|Yan, Shengyong|Yan, Shengyong|Weng, Xiaocheng|Weng, Xiaocheng|Wu, Xiaojun|Wu, Xiaojun|Deng, Minggang|Deng, Minggang|Zhou, Xiang|Zhou, Xiang| |
| 21 | Review: Advances in methodology of DNA methylation assay | 期刊论文 | Tian Tian|Tian Tian|Wang ShaoRu|Wang ShaoRu|Wu JianGuo|Wu JianGuo|Zhou Xiang|Zhou Xiang| |
| 22 | Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA | 期刊论文 | Zheng, Ke-wei|Chen, Zhao|Hao, Yu-hua|Tan, Zheng| |
| 23 | Highly enantioselective addition of linear alkyl alkynes to linear aldehydes | 期刊论文 | Du, Yuhao|Turlington, Mark|Zhou, Xiang|Pu, Lin| |
| 24 | Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission | 期刊论文 | Huang, Jing|Wang, Ming|Zhou, Yangyang|Weng, Xiaocheng|Shuai, Liang|Zhou, Xiang|Zhang, Deqing| |
| 25 | Pyridyl-Substituted Corrole Isomers: Synthesis and their Regulation to G-quadruplex Structures | 期刊论文 | Ma, Heng|Ma, Heng|Deng, Minggang|Deng, Minggang|Xu, Liang|Xu, Liang|Zhou, Xiang|Zhou, Xiang|Zhang, Ming|Zhang, Ming|Zhang, Dan|Zhang, Dan|Huang, Rong|Huang, Rong|Zhao, Yang|Zhao, Yang|Yang, Hao|Yang, Hao|Liu, Yijing|Liu, Yijing|Weng, Xiaocheng|Weng, Xiaoc |
| 26 | Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives | 期刊论文 | Bai, Minghui|Bai, Minghui|Zhou, Xiang|Zhou, Xiang|Huang, Jing|Huang, Jing|Zheng, Xiaolong|Zheng, Xiaolong|Song, Zhibin|Song, Zhibin|Tang, Miru|Tang, Miru|Mao, Wuxiang|Mao, Wuxiang|Yuan, Libo|Yuan, Libo|Wu, Jun|Wu, Jun|Weng, Xiaocheng|Weng, Xiaocheng| |
| 27 | 联邻苯二酚类小分子作为DNA交联剂的研究 | 会议论文 | 白明慧|翁小成|周翔| |
| 28 | A novel cationic triazatetrabenzcorrole: selective detection of mercury(II) by nucleic acid-induced aggregation | 期刊论文 | Zhou, Yangyang|Zhou, Yangyang|Deng, Minggang|Deng, Minggang|Du, Yuanyuan|Du, Yuanyuan|Yan, Shengyong|Yan, Shengyong|Huang, Rong|Huang, Rong|Weng, Xiaocheng|Weng, Xiaocheng|Yang, Chuluo|Yang, Chuluo|Zhang, Xiaolian|Zhang, Xiaolian|Zhou, Xiang|Zhou, Xiang| |
| 29 | 核酸交联剂:设计合成及药物活性研究 | 会议论文 | 翁小成|翁小成|白明慧|白明慧|周翔|周翔| |
| 30 | Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition | 期刊论文 | Chen, Zhao|Zheng, Ke-wei|Hao, Yu-hua|Tan, Zheng| |
| 31 | Structural polymorphism of human telomere G-quadruplex induced by a pyridyl carboxamide molecule | 期刊论文 | Xu, Liang|Xu, Liang|Xu, Zhouxin|Xu, Zhouxin|Shang, Ye|Shang, Ye|Feng, Shuo|Feng, Shuo|Zhou, Xiang|Zhou, Xiang| |
| 32 | Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition | 期刊论文 | Du, Yuhao|Du, Yuhao|Zhang, Dan|Zhang, Dan|Chen, Wei|Chen, Wei|Zhang, Ming|Zhang, Ming|Zhou, Yangyang|Zhou, Yangyang|Zhou, Xiang|Zhou, Xiang| |
| 33 | 核酸结构调控和功能研究 | 会议论文 | 周翔|周翔|翁小成|翁小成|王少儒|王少儒|Xiang Zhou*, Xiaocheng Weng, Shaoru Wang College o|Xiang Zhou*, Xiaocheng Weng, Shaoru Wang College o| |
| 34 | Visual Detection of rpoB Mutations in Rifampin-Resistant Mycobacterium tuberculosis Strains by Use of an Asymmetrically Split Peroxidase DNAzyme | 期刊论文 | Deng, Minggang|Deng, Minggang|Feng, Shuo|Feng, Shuo|Luo, Fengling|Luo, Fengling|Wang, Shaoru|Wang, Shaoru|Sun, Xiaoming|Sun, Xiaoming|Zhou, Xiang|Zhou, Xiang|Zhang, Xiao-Lian|Zhang, Xiao-Lian| |
| 35 | Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex | 期刊论文 | Huang, Jing|Li, Guorui|Wu, Zhiguo|Song, Zhibin|Zhou, Yangyang|Shuai, Liang|Weng, Xiaocheng|Zhou, Xiang|Yang, Guangfu| |
| 36 | A specific probe for two-photon fluorescence lysosomal imaging | 期刊论文 | Wu, Zhiguo|Wu, Zhiguo|Wang, Chunjiang|Wang, Chunjiang|Zhou, Xiang|Zhou, Xiang|Tang, Mingliang|Tang, Mingliang|Tian, Tian|Tian, Tian|Wu, Jianguo|Wu, Jianguo|Deng, Yuanlin|Deng, Yuanlin|Dong, Xiaohu|Dong, Xiaohu|Tan, Zheng|Tan, Zheng|Weng, Xiaocheng|Weng, X |
| 37 | Sensitive and Visual Detection of Adenosine by a Rationally Designed FokI-Based Biosensing Strategy | 期刊论文 | Zhang, Ming|Huang, Jing|Deng, Minggang|Weng, Xiaocheng|Ma, Heng|Zhou, Xiang| |
| 38 | A pyridyl carboxamide molecule selectively stabilizes DNA G-quadruplex and regulates duplex-quadruplex competition | 期刊论文 | Xu, Liang|Xu, Liang|Wu, Weixin|Wu, Weixin|Ding, Jie|Ding, Jie|Feng, Shuo|Feng, Shuo|Xing, Xiwen|Xing, Xiwen|Deng, Minggang|Deng, Minggang|Zhou, Xiang|Zhou, Xiang| |
| 39 | 小分子对核酸结构的调控研究 | 会议论文 | 吴志国|吴志国|徐亮|徐亮|翟倩倩|翟倩倩|翁小成|翁小成|周翔|周翔| |
| 40 | Advancements in Z-DNA: Development of Inducers and Stabilizers for B to Z Transition | 期刊论文 | Yang, L.|Yang, L.|Wang, S.|Wang, S.|Tian, T.|Tian, T.|Zhou, X.|Zhou, X.| |
| 41 | Kinetic and Thermodynamic Control of G-Quadruplex Folding | 期刊论文 | Xue, Yong|Liu, Jia-quan|Zheng, Ke-wei|Kan, Zhong-yuan|Hao, Yu-hua|Tan, Zheng| |
| 42 | Formation of Sequence-Independent Z-DNA Induced by a Ruthenium Complex at Low Salt Concentrations | 期刊论文 | Wu, Zhiguo|Wu, Zhiguo|Tian, Tian|Tian, Tian|Yu, Junping|Yu, Junping|Weng, Xiaocheng|Weng, Xiaocheng|Liu, Yi|Liu, Yi|Zhou, Xiang|Zhou, Xiang| |
| 43 | Some cationic porphyrins: synthesis, stabilization of G-qua druplexes, and down-regulation of c-myc in Hep G2 cells | 期刊论文 | Wang, Shao R.|Zhang, Dan|Luo, Feng L.|Liu, Lin|Weng, Xiao C.|Huang, Jing|Li, Guo R.|Zhang, Xiao L.|Zhou, Xiang| |
| 44 | QUADRUPLEX-DUPLEX MOTIFS AS NEW TOPOISOMERASE I INHIBITORS | 期刊论文 | Shuai, Li|Deng, Minggang|Zhang, Dan|Zhou, Yangyang|Zhou, Xiang| |
| 45 | Dissecting the Strand Folding Orientation and Formation of G-Quadruplexes in Single- and Double-Stranded Nucleic Acids by Ligand-Induced Photocleavage Footprinting | 期刊论文 | Zheng, Ke-wei|Zhang, Dan|Zhang, Li-xia|Hao, Yu-hua|Zhou, Xiang|Tan, Zheng| |
| 46 | A Two-photon Fluorescent Probe for Intracellular Detection of Tyrosinase Activity | 期刊论文 | Yan, Shengyong|Yan, Shengyong|Huang, Rong|Huang, Rong|Wang, Changcheng|Wang, Changcheng|Zhou, Yimin|Zhou, Yimin|Wang, Jiaqi|Wang, Jiaqi|Fu, Boshi|Fu, Boshi|Weng, Xiaocheng|Weng, Xiaocheng|Zhou, Xiang|Zhou, Xiang| |
| 47 | Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme | 期刊论文 | Tian, Tian|Tian, Tian|Xiao, Heng|Xiao, Heng|Long, Yuelin|Long, Yuelin|Zhang, Xiaoe|Zhang, Xiaoe|Wang, Shaoru|Wang, Shaoru|Zhou, Xiang|Zhou, Xiang|Liu, Songmei|Liu, Songmei|Zhou, Xin|Zhou, Xin| |
| 48 | 小分子化合物对核酸结构调控作用研究 | 会议论文 | 王小琳|徐亮|翁小成|周翔|Xiaolin Wang, Liang Xu, Xiang Zhou* College of Che| |
| 49 | Selective cleavage of DNA at guanosine bases which locate in DNA non-duplex portions within duplexes by ruthenium(II) complexes | 期刊论文 | Liu, Lin|Liu, Lin|Zhai, Qianqian|Zhai, Qianqian|Hong, Tingting|Hong, Tingting|Ge, Yushu|Ge, Yushu|Hu, Peng|Hu, Peng|Weng, Xiaocheng|Weng, Xiaocheng|Liu, Yi|Liu, Yi|Zhou, Xiang|Zhou, Xiang| |
| 50 | Exploring Quaternized Hydroxyethylcellulose as Potential Gene Carriers | 期刊论文 | Ding Fei|Ding Fei|You Jun|You Jun|Weng Xiaocheng|Weng Xiaocheng|Zhou Jinping|Zhou Jinping|Zhang Xiaolian|Zhang Xiaolian|Zhou Xiang|Zhou Xiang|Zhang Lina|Zhang Lina| |
| 51 | 磷硫酰化的人端粒序列被二价汞离子诱导形成G-四链体结构 | 会议论文 | 章丹|邓明刚|周翔| |
| 52 | Site-Specific Recognition of Guanosine by Manganese(III) Corroles in DNA Non-Duplex Regions through Active Oxygen Transfer | 期刊论文 | Zhai, Qianqian|Zhai, Qianqian|Zhou, Xiang|Zhou, Xiang|Xu, Liang|Xu, Liang|Ge, Yushu|Ge, Yushu|Tian, Tian|Tian, Tian|Wu, Wendi|Wu, Wendi|Yan, Shengyong|Yan, Shengyong|Zhou, Yangyang|Zhou, Yangyang|Deng, Minggang|Deng, Minggang|Liu, Yi|Liu, Yi| |
| 53 | Studies of the Activity of Peroxidase-Like DNAzyme by Modifying 3 ';- or 5 ';-End of Aptamers | 期刊论文 | Zhang, Ming|Zhang, Ming|Li, Haiqun|Li, Haiqun|Deng, Minggang|Deng, Minggang|Weng, Xiaocheng|Weng, Xiaocheng|Ma, Heng|Ma, Heng|Feng, Shuo|Feng, Shuo|Zhou, Yangyang|Zhou, Yangyang|Zhou, Xiang|Zhou, Xiang| |
| 54 | Dipyrrolylquinoxaline-bridged hydrazones: a new class of chemosensors for copper(II) | 期刊论文 | Guo, Qian-ni|Zhong, Cheng|Lu, Yun-guo|Shi, Chuang|Li, Zao-ying| |
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