PI3Kα/钙调蛋白协调调控K-Ras4B在胰腺导管腺癌中的分子机制及靶点识别

21778037
2017
B0702.生物分子的化学生物学
陆绍永
面上项目
研究员
上海交通大学
65万元
蛋白质-蛋白质相互作用;消化道肿瘤;分子模拟;靶点识别;原癌基因
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Emerging roles of allosteric modulators in the regulation of protein-protein interactions (PPIs): A new paradigm for PPI drug discovery 期刊论文 Ni Duan;Lu Shaoyong;Zhang Jian
2 Discovery of hidden allosteric sites as novel targets for allosteric drug design 期刊论文 Lu Shaoyong;Ji Mingfei;Ni Duan;Zhang Jian
3 Rational Design of Peptide-Based Inhibitors Disrupting Protein-Protein Interactions 期刊论文 Wang Xuefei;Ni Duan;Liu Yaqin;Lu Shaoyong
4 Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit 期刊论文 Wang Guanqiao;Zhang Mingzhen;Jang Hyunbum;Lu Shaoyong;Lin Shizhou;Chen Guoqiang;Nussinov Ruth;Zhang Jian;Gaponenko Vadim
5 Deactivation Pathway of Ras GTPase Underlies Conformational Substates as Targets for Drug Design 期刊论文 Lu Shaoyong;Ni Duan;Wang Chengxiang;He Xinheng;Lin Houwen;Wang Zheng;Zhang Jian
6 Emergence of allosteric drugresistance mutations: new challenges for allosteric drug discovery 期刊论文 Lu Shaoyong;Qiu Yuran;Ni Duan;He Xinheng;Pu Jun;Zhang Jian
7 Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling Proteins 期刊论文 Wang Yuanhao;Ji Dong;Lei Chaoyu;Chen Yingfei;Qiu Yuran;Li Xinyi;Li Mingyu;Ni Duan;Pu Jun;Zhang Jian;Fu Qiang;Liu Yaqin;Lu Shaoyong
8 Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators 期刊论文 Qiu Yuran;Wang Yuanhao;Chai Zongtao;Ni Duan;Li Xinyi;Pu Jun;Chen Jie;Zhang Jian;Lu Shaoyong;Lv Chuan;Ji Mingfei
9 Insight into the mechanism of allosteric activation of PI3K alpha by oncoprotein K-Ras4B 期刊论文 Li Xinyi;Dai Jinyuan;Ni Duan;He Xinheng;Zhang Hao;Zhang Jian;Fu Qiang;Liu Yaqin;Lu Shaoyong
10 Drugging K-Ras(G12C) through covalent inhibitors: Mission possible? 期刊论文 Ni Duan;Li Xinyi;He Xinheng;Zhang Hao;Zhang Jian;Lu Shaoyong
11 Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85 Regulatory Subunit of PI3K: Implication for PI3K Activation by Calmodulin 期刊论文 Ni Duan;Liu Dingyu;Zhang Jian;Lu Shaoyong
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