组蛋白变体H1.2调控细胞衰老进而影响糖尿病视网膜病变机制研究
31871381
2018
C0705.细胞衰老、死亡及自噬
郑凌
面上项目
教授
武汉大学
60万元
组织器官退行性变化;PARP-1;DNA;细胞老化;损伤反应;组蛋白H1.2
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Histone demethylase UTX is a therapeutic target for diabetic kidney disease. | 期刊论文 | Hong Chen;Yixue Huang;Xiuqin Zhu;Chong Liu;Yangmian Yuan;Hua Su;Chun Zhang;Chengyu Liu;Mingrui Xiong;Yannan Qu;Peng Yun;Ling Zheng;Kun Huang |
| 2 | Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms | 期刊论文 | Yixue Huang;Yunhao Xie;Dong Yang;Mingrui Xiong;Xingrui Chen;Di Wu;Qing Wang;Yuchen Chen;Ling Zheng;Kun Huang |
| 3 | Histone methyltransferase G9a protects against acute liver injury through GSTP1 | 期刊论文 | Zhang Yu;Xue Weili;Zhang Wenquan;Yuan Yangmian;Zhu Xiuqin;Wang Qing;Wei Yujuan;Yang Dong;Yang Chen;Chen Yan;Sun Yu;Wang Shun;Huang Kun;Zheng Ling |
| 4 | Fat-Specific Knockout of Mecp2 Upregulates Slpi to Reduce Obesity by Enhancing Browning | 期刊论文 | Liu Chengyu;Wang Jiao;Wei Yujuan;Zhang Wenquan;Geng Mengyuan;Yuan Yangmian;Chen Yuchen;Sun Yu;Chen Hong;Zhang Yu;Xiong Mingrui;Li Yangkai;Zheng Ling;Huang Kun |
| 5 | Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress | 期刊论文 | Yuan Yangmian;Liu Chengyu;Chen Xingrui;Sun Yuyan;Xiong Mingrui;Fan Yu;Petersen Robert B.;Chen Hong;Huang Kun;Zheng Ling |
| 6 | Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p | 期刊论文 | Sun Yu;Wang Qing;Zhang Yu;Geng Mengyuan;Wei Yujuan;Liu Yanrui;Liu Shanshan;Petersen Robert B.;Yue Junqiu;Huang Kun;Zheng Ling |
| 7 | Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling | 期刊论文 | Qing Wang;Yuchen Chen;Yunhao Xie;Dong Yang;Yuyan Sun;Yangmian Yuan;Hong Chen;Yu Zhang;Kun Huang;Ling Zheng |
| 8 | Mecp2 protects kidney from ischemia-reperfusion injury through transcriptional repressing IL-6/STAT3 signaling | 期刊论文 | Jiao Wang;Mingrui Xiong;Yu Fan;Chengyu Liu;Qing Wang;Dong Yang;Yangmian Yuan;Yixue Huang;Shun Wang;Yu Zhang;Shuxuan Niu;Junqiu Yue;Hua Su;Chun Zhang;Hong Chen;Ling Zheng;Kun Huang |
| 9 | Lmo4‐resistin signaling contributes to adipose tissue‐liver crosstalk upon weight cycling | 期刊论文 | Sun Yu;Geng Mengyuan;Yuan Yangmian;Guo Peilian;Chen Yuchen;Yang Dong;Petersen Robert B.;Huang Kun;Zheng Ling |
| 10 | Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication | 期刊论文 | Yuchen Chen;Dong Yang;Biao Cheng;Jian Chen;Anlin Peng;Chen Yang;Chong Liu;Mingrui Xiong;Aiping Deng;Yu Zhang;Ling Zheng;Kun Huang |
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