基于关节软骨多元耦合仿生的分层制备及其在多参数调控动态环境中有效构建的协同作用机制

31670978
2016
C1002.生物材料与生物效应
宋克东
面上项目
研究员
大连理工大学
62万元
生物相容性;复合材料设计;梯度;仿生复合材料;界面
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 多壁碳纳米管在骨组织工程复合支架中的应用及其在体外对细胞生长的影响 奖励 徐杰;刘天庆;宋克东
2 一种细胞三维扩增培养用微载体的制备方法 专利 宋克东;李丽颖;孔倩;李文芳;刘天庆
3 Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids 会议论文 Kong Q;Zheng SS;Liu TQ;Nie Y;Song KD
4 Fabrication and development of artificial osteochondral constructs based on cancellous bone/chitosan-gelatin hydrogel hybrid Scaffold 会议论文 Song K;Li L;Li W;Hu X;Liu T
5 Evaluation of inhibitory effects of geniposide on a tumor model of human breast cancer based on 3D printed Cs/Gel hybrid scaffold. 期刊论文 Lv K;Zhu J;Zheng S;Jiao Z;Nie Y;Song F;Liu T;Song K
6 Biophysical Characterization of Poly (l-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite 会议论文 Li LY;Liu TQ;Li XQ;Song KD
7 Influence of copolymer grafting density on cell adhesion performance onto surface of a novel thermosensitive chitosan membrane 会议论文 Song K;Li L;Hu X;Wang Y;Liu T
8 一种壳聚糖基梯度仿生复合支架材料及其构建方法 专利 宋克东;卢延国;李丽颖;李文芳;刘天庆
9 Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells. 会议论文 Lv K;Zheng S;Li X;Nie Y;Liu T;Song K
10 一种三维肿瘤模型脱细胞衍生基质支架的构建方法及其应用 专利 宋克东;郑乐;李丽颖;胡雪岩;徐杰;李香琴;刘天庆
11 A novel tissue-engineered 3D tumor model for anti-cancer drug discovery 期刊论文 Li Wenfang;Hu Xueyan;Yang Shuaitao;Wang Shuping;Zhang Chenghong;Wang Hai;Cheng Yuen Yee;Wang Yiwei;Liu Tianqing;Song Kedong
12 Effects of concentration variation on the physical properties of alginate-based substrates and cell behavior in culture 奖励 李丽颖;宋克东;刘天庆
13 A biomimetic cartilage gradient hybrid scaffold for functional tissue engineering of cartilage 期刊论文 Hu Xueyan;Li Wenfang;Li Liying;Lu Yanguo;Wang Yiwei;Parungao Roxanne;Zheng Shuangshuang;Liu Tianqing;Nie Yi;Wang Hongfei;Song Kedong
14 基于物理掺杂与表面修饰设计与表征聚乳酸基微载体 奖励 李丽颖;宋克东;陈涌智;刘天庆
15 基于脱细胞基质的新型3D肿瘤模型的构建及评估 奖励 李文芳;胡雪岩;宋克东;刘天庆
16 D Bio-Printing Fabrication and Properties of Graphene Dispersion-based Hybrid Scaffolds. 会议论文 Peng J;Li L;Nie Y;Liu T;Song K
17 Preparation of temperature-sensitive P (CS-g-TMSPM-g-NIPAAm) copolymer using a chemical cross-linking method 期刊论文 Song Kedong;Li Liying;Tian Jiaxin;Wang Mengyu;Wang Yiwei;Liu Tianqing
18 一种用于造血干细胞体外培养的免疫隔离动态共培养生物反应器 专利 宋克东;李丽颖;聂毅;胡雪岩;杨延飞;刘天庆
19 Comparison and evaluation of tissue-engineered 3D tumor model based on different resources of biomaterials 会议论文 Li WF;Li XQ;Liu TQ;Song KD
20 基于水凝胶-松质骨的组织工程骨软骨复合物的动态构建 奖励 宋克东;李文芳;王海;李丽颖
21 The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro 期刊论文 Xu Jie;Hu Xueyan;Jiang Siyu;Wang Yiwei;Parungao Roxanne;Zheng Shuangshuang;Nie Yi;Liu Tianqing;Song Kedong
22 Effects of concentration variation on the physical properties of alginate-based substrates and cell behavior in culture 期刊论文 Li Liying;Chen Yongzhi;Wang Yiwei;Shi Fangxin;Nie Yi;Liu Tianqing;Song Kedong
23 Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation 期刊论文 Li Wenfang;Hu Xueyan;Wang Shuping;Jiao Zeren;Sun Tongyi;Liu Tianqing;Song Kedong
24 Characterization of human adipose tissue-derived stem cells in vitro culture and in vivo differentiation in a temperature-sensitive chitosan/beta-glycerophosphate/collagen hybrid hydrogel 期刊论文 Song Kedong;Li Liying;Yan Xinyu;Zhang Wen;Zhang Yu;Wang Yiwei;Liu Tianqing
25 Characterization of human adipose tissue-derived stem cells in vitro culture and in vivo differentiation in a temperature-sensitive chitosan/β-glycerophosphate/collagen hybrid hydrogel frame 奖励 宋克东;刘天庆;闫新宇;李丽颖
26 一种聚乳酸/羟基磷灰石/脱细胞羊膜复合支架及其构建方法 专利 宋克东;闫新宇;卢延国;李丽颖;李文芳;刘天庆
27 基于物理掺杂与表面修饰设计与表征聚乳酸基微载体 会议论文 李丽颖;宋克东;陈涌智;李文芳;刘天庆
28 Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo 期刊论文 Li Wenfang;Hu Xueyan;Wang Shuping;Xing Yan;Wang Hai;Nie Yi;Liu Tianqing;Song Kedong
29 Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation 期刊论文 Li Wenfang;Song Kedong;Wang Shuping;Zhang Chenghong;Zhuang Meiling;Wang Yiwei;Liu Tianqing
30 Development of decellularized meniscus extracellular matrix and gelatin/chitosan scaffolds for meniscus tissue engineering 期刊论文 Zhang Yu;Jiang Lili;Zheng Tiezheng;Sha Li;Wang Jianzhuang;Dong Haichao;Song Kedong;Liu Tianqing
31 3D Bio-Printing Fabrication and Properties of Graphene Dispersion-based Hybrid Scaffolds. 期刊论文 Peng J;Li L;Nie Y;Liu T;Song K
32 Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting 期刊论文 Xu J;Zheng S;Hu X;Li L;Li W;Parungao R;Wang Y;Nie Y;Liu T;Song K
33 梯度骨软骨复合物的体外构建与生物相容性检测 会议论文 胡雪岩;宋克东;李文芳;李丽颖;刘天庆
34 Development and fabrication of a two-layer tissue engineered osteochondral composite using hybrid hydrogel-cancellous bone scaffolds in a spinner flask 期刊论文 Song Kedong;Li Wenfang;Wang Hai;Zhang Yu;Li Liying;Wang Yiwei;Wang Hong;Wang Ling;Liu Tianqing
35 一种含碳纳米管的复合多孔支架及其制备方法 专利 宋克东;蒋思宇;卢延国;李文芳;李丽颖;刘天庆
36 Detection and Evaluation of Anti-Cancer Efficiency of Astragalus Polysaccharide Via a Tissue Engineered Tumor Model 期刊论文 Li Wenfang;Hu Xueyan;Wang Shuping;Wang Hai;Parungao Roxanne;Wang Yiwei;Liu Tianqing;Song Kedong
37 Development and Fabrication of a Two-layer Tissue Engineered Osteochondral Composite using Hybrid Hydrogel-Cancellous Bone Scaffolds in a Bioreactor 会议论文 Song K;Li W;Wang Y;Liu T
38 Numerical Simulation of Immunoisolated Co-culture Bioreactor for in Vitro Expansion of Human Hematopoietic Stem Cells 会议论文 Man Y;Li L;Zheng S;Nie Y;Liu T;Song K
39 Effects of concentration variation on the physical properties of alginate-based substrates and cell behavior in culture. 会议论文 Li LY;Li XQ;Liu TQ;Song KD
40 Numerical Simulation of Immunoisolated Co-culture Bioreactor for in Vitro Expansion of Human Hematopoietic Stem Cells. 期刊论文 Man Y;Li L;Nie Y;Liu T;Song K
41 体外构建壳聚糖/β-甘油磷酸钠/明胶仿生梯度支架 期刊论文 胡雪岩;宋克东;卢延国;李文芳;李丽颖;郑双双;刘天庆
42 Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells 期刊论文 Lv Kena;Zheng Shuangshuang;Li Xiangqin;Nie Yi;Liu Tianqing;Song Kedong
43 Effect of thermal-responsive surfaces based on PNIPAAm on cell adsorption/desorption 期刊论文 Bi Jiajie;Song Kedong;Wu Suli;Zhang Yu;Wang Yiwei;Liu Tianqing
44 Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering 会议论文 Wenfang Li;Xueyan Hu;Tianqing Liu;Kedong Song
45 Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair 期刊论文 Hu Xueyan;Xu Jie;Li Wenfang;Li Liying;Parungao Roxanne;Wang Yiwei;Zheng Shuangshuang;Nie Yi;Liu Tianqing;Song Kedong
46 一种掺杂石墨烯的仿生复合支架材料及其构建方法 专利 宋克东;卢延国;李丽颖;李文芳;胡雪岩;刘天庆
47 A novel tissue-engineered 3D tumor model for anti-cancer drug discovery. 会议论文 Li WF;Li XQ;Liu TQ;Song KD
48 Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation. 会议论文 Song K;Li W;Wang Y;Nie Y;Liu T
49 Engineering gelatin-based alginate/carbon nanotubes blend bioink for direct 3D printing of vessel constructs 期刊论文 Li Liying;Qin Shuai;Peng Jun;Chen Ang;Nie Yi;Liu Tianqing;Song Kedong
50 一种三维肿瘤模型脱细胞多孔支架、构建方法及其应用 专利 宋克东;李文芳;李丽颖;胡雪岩;刘天庆
51 Numerical Simulation for Distribution and Mass Transfer of Nutrient Substance within Microbeads in Different Culture Systems. 会议论文 Song K;Qin S;Lu Y;Tian J;Wang Y;Liu T
52 Toxicological evaluation of ionic liquid in a biological functional tissue construct model based on nano-hydroxyapatite/chitosan/gelatin hybrid scaffolds 期刊论文 Jingjing Zhu;Qian Kong;Shuangshuang Zheng;Yiwei Wang;Zeren Jiao;Yi Nie;Tianqing Liu;Kedong Song
53 Ex Vivo Expansion of Hematopoietic Stem/Progenitor Cells supported by Microencapsulated Osteoblasts under a Hypoxia environment. 会议论文 Song K;Li L;Li W;Hu X;Liu T
54 A biomimetic cartilage gradient hybrid scaffolds for functional tissue engineering of cartilage. 会议论文 Hu XY;Li XQ;Liu TQ;Song KD
55 Effects of concentration variation on the physical properties of alginate-based substrates and cell behavior in culture 会议论文 李丽颖;宋克东;刘天庆
56 Design and characterization of poly (L-lactic) acid microcarriers with and without modification of chitosan and nanohydroxyapatite. 会议论文 Li L;Song K;Nie Y;Liu T
57 3D Bio-Printing of CS/Gel/HA/Gr Hybrid Osteochondral Scaffolds 期刊论文 Hu Xueyan;Man Yuan;Li Wenfang;Li Liying;Xu Jie;Parungao Roxanne;Wang Yiwei;Zheng Shuangshuang;Nie Yi;Liu Tianqing;Song Kedong
58 In Vitro Fabrication and Biocompatibility Assay of a Biomimetic Osteoblastic Niche 期刊论文 Song Kedong;Kong Qian;Li Liying;Wang Yiwei;Parungao Roxanne;Zheng Shuangshuang;Nie Yi;Jiao Zeren;Wang Hongfei;Liu Tianqing
59 Design and modification of poly (L-lactic) acid microcarriers and their biocompatibility for MC3T3-E1 cells culture 会议论文 Song K;Li L;Wang Y;Nie Y;Liu T
60 多壁碳纳米管在骨组织工程复合支架中的应用及其在体外对细胞生长的影响 会议论文 徐杰;刘天庆;宋克东
61 一种用于造血干细胞体外培养的免疫隔离动态共培养生物反应器 专利 宋克东;李丽颖;聂毅;胡雪岩;杨延飞;刘天庆
62 Design and Biophysical Characterization of Poly (L-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite 期刊论文 Li Liying;Song Kedong;Chen Yongzhi;Wang Yiwei;Shi Fangxin;Nie Yi;Liu Tianqing
63 一种三维肿瘤模型脱细胞多孔支架、构建方法及其应用 专利 宋克东;李文芳;李丽颖;胡雪岩;刘天庆
64 多壁碳纳米管在骨组织工程复合支架中的应用及其在体外对细胞生长的影响 奖励 徐杰;刘天庆;宋克东
65 Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids. 期刊论文 Kong Q;Zheng SS;Liu TQ;Nie Y;Song KD
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