心力衰竭中血管稳态和重构的转录后调控机制研究
91439203
2014
H0202.心肌损伤、修复、重构和再生
汪道文
重大研究计划
教授
华中科技大学
270万元
心肌血管新生;心力衰竭;非编码RNAs;血管稳态;转录后调控
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases | 期刊论文 | Xu Xizhen;Li Rui;Chen Guangzhi;Hoopes Samantha L.;Zeldin Darryl C.;Wang Dao Wen |
| 2 | Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo | 期刊论文 | Duan Quanlu;Ni Li;Wang Peihua;Chen Chen;Yang Lei;Ma Ben;Gong Wei;Cai Zhejun;Zou Ming-Hui;Wang Dao Wen |
| 3 | Gene variants in responsiveness to clopidogrel have no impact on clinical outcomes in Chinese patients undergoing percutaneous coronary intervention - A multicenter study | 期刊论文 | Li Chenze;Zhang Lina;Wang Haoran;Li Sha;Zhang Yan;You Ling;Sun Yang;Wang Dong;Yang Jun;Cui Yinghua;Cao Yanyan;Shen Xiaoqing;Wang Yan;Cui Wei;Yan Jiangtao;Zeng Hesong;Guo Xiaomei;Li Jianjun;Wang Dao Wen |
| 4 | Relationship Between beta-Blocker Therapy at Discharge and Clinical Outcomes in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention | 期刊论文 | Li Chenze;Sun Yang;Shen Xiaoqing;Yu Ting;Li Qing;Ruan Guoran;Zhang Lina;Huang Qiang;Zhuang Hang;Huang Jingqiu;Ni Li;Wang Luyun;Jiang Jiangang;Wang Yan;Wang Dao Wen |
| 5 | microRNA-320(miR-320a)及其反义核苷酸在诊断、防治心血管疾病中的用途 | 专利 | 汪道文;陈琛;杨盛兰;王峰;龙光文 |
| 6 | 表达hsa-miR-21的重组腺相关病毒的制备方法及其在高血压病治疗中的用途 | 专利 | 汪道文;陈琛;王峰;杨盛兰;马飞 |
| 7 | Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure | 期刊论文 | Sandip Chaugal;Tan Lun;Huang Jin;Li Qing;Ni Li;Cianflone Katherine;Wang Dao Wen |
| 8 | 用于治疗心力衰竭的药物及其筛选方法和制备方法 | 专利 | 汪道文;陈琛;李华萍;樊佳慧 |
| 9 | Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling | 期刊论文 | Nie Jiali;Duan Quanlu;He Mengying;Li Xianqing;Wang Bei;Zhou Chi;Wu Lujin;Wen Zheng;Chen Chen;Wang Dao Wu;Alsina Katherina M;Wehrens Xander H T;Wang Dao Wen;Ni Li |
| 10 | MiR-665 aggravates heart failure via suppressing CD34-mediated coronary microvessel angiogenesis | 期刊论文 | Fan Jiahui;Li Huaping;Nie Xiang;Yin Zhongwei;Zhao Yanru;Zhang Xudong;Yuan Shuai;Li Yuying;Chen Chen;Wang Dao Wen |
| 11 | MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo | 期刊论文 | Duan Quanlu;Chen Chen;Yang Lei;Li Ni;Gong Wei;Li Sheng;Wang Dao Wen |
| 12 | CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK2 and enhancing nuclear translocation of Akt1 | 期刊论文 | Wang Bei;Zeng Hesong;Wen Zheng;Chen Chen;Wang Dao Wen |
| 13 | MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis | 期刊论文 | Duan Quanlu;Yang Lei;Gong Wei;Chaugai Sandip;Wang Feng;Chen Chen;Wang Peihua;Zou Ming-Hui;Wang Dao Wen |
| 14 | MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation | 期刊论文 | Li Huaping;Zhang Xiaorong;Wang Feng;Zhou Ling;Yin Zhongwei;Fan Jiahui;Nie Xiang;Wang Peihua;Fu Xiang-Dong;Chen Chen;Wang Dao Wen |
| 15 | miR-320a mediates doxorubicin-induced cardiotoxicity by targeting VEGF signal pathway | 期刊论文 | Zhongwei Yin;Yanru Zhao;Huaping Li;Mengwen Yan;Ling Zhou;Chen Chen;Dao Wen Wang |
| 16 | 慢性心力衰竭相关的血清miRNA及其应用 | 专利 | 汪道文;陈琛;李华萍 |
| 17 | 血管生物学(第二版) | 专著 | 陈琛;汪道文 |
| 18 | Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients | 期刊论文 | Sun Yang;Li Chenze;Zhang Lina;Hu Dong;Zhang Xudong;Yu Ting;Tao Min;Wang Dao Wen;Shen Xiaoqing |
| 19 | MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin | 期刊论文 | Dai Beibei;Li Huaping;Fan Jiahui;Zhao Yanru;Yin Zhongwei;Nie Xiang;Wang Dao Wen;Chen Chen |
| 20 | 基于hsa-miR-320a的防治糖尿病的药物及其筛选方法和制备方法 | 专利 | 汪道文;陈琛;李华萍;殷中伟 |
| 21 | AMPK2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation | 期刊论文 | Wang Bei;Nie Jiali;Wu Lujin;Hu Yangyang;Wen Zheng;Dong Lingli;Zou Ming-Hui;Chen Chen;Wang Dao Wen |
| 22 | MiR-30c/PGC-1beta protects against diabetic cardiomyopathy via PPARalpha | 期刊论文 | Yin Zhongwei;Zhao Yanru;He Mengying;Li Huaping;Fan Jiahui;Nie Xiang;Yan Mengwen;Chen Chen;Wang Dao Wen |
| 23 | Decreased Peripheral Mitochondrial DNA Copy Number is Associated with the Risk of Heart Failure and Long-term Outcomes | 期刊论文 | Huang Jin;Tan Lun;Shen Rufei;Zhang Lina;Zuo Houjuan;Wang Dao W. |
| 24 | Mir30c Is Involved in Diabetic Cardiomyopathy through Regulation of Cardiac Autophagy via BECN1 | 期刊论文 | Chen Chen;Yang Shenglan;Li Huaping;Yin Zhongwei;Fan Jiahui;Zhao Yanru;Gong Wei;Yan Mengwen;Wang Dao Wen |
| 25 | miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN | 期刊论文 | Nie Xiang;Fan Jiahui;Li Huaping;Yin Zhongwei;Zhao Yanru;Dai Beibei;Dong Nianguo;Chen Chen;Wang Dao Wen |
| 26 | Recombinant Adeno-Associated Virus-Mediated Delivery of MicroRNA-21-3p Lowers Hypertension | 期刊论文 | Wang Feng;Fang Qin;Chen Chen;Zhou Ling;Li Huaping;Yin Zhongwei;Wang Yan;Zhao Chun Xia;Xiao Xiao;Wang Dao Wen |
| 27 | Identification of cardiac long non-coding RNA profile in human dilated cardiomyopathy | 期刊论文 | Li Huaping;Chen Chen;Fan Jiahui;Yin Zhongwei;Ni Li;Cianflone Katherine;Wang Yan;Wang Dao Wen |
| 28 | 基于hsa-miR-320a的糖尿病早期预警和或诊断试剂盒的制备方法 | 专利 | 汪道文;陈琛;李华萍;殷中伟 |
| 29 | Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3 | 期刊论文 | Zhou Ning;Ye Yong;Wang Xingxu;Ma Ben;Wu Jian;Li Lei;Wang Lin;Wang Dao Wen;Zou Yunzeng |
| 30 | MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice | 期刊论文 | Zhao Yanru;Yin Zhongwei;Li Huaping;Fan Jiahui;Yang Shenglan;Chen Chen;Wang Dao Wen |
| 31 | Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection | 期刊论文 | Li Zongzhe;Zhou Chengming;Tan Lun;Chen Peng;Cao Yanyan;Li Chenze;Li Xianqing;Yan Jiangtao;Zeng Hesong;Wang Dao-Wu;Wang Dao-Wen |
| 32 | P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice | 期刊论文 | Wu Lujin;Zhao Fujie;Dai Meiyan;Li Huaping;Chen Chen;Nie Jiali;Wang Peihua;Wang Dao Wen |
| 33 | Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration | 期刊论文 | Chen Jing;Wang Bei;Lai Jinsheng;Braunstein Zachary;He Mengying;Ruan Guoran;Yin Zhongwei;Wang Jin;Cianflone Katherine;Ning Qin;Chen Chen;Wang Dao Wen |
| 34 | ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to beta-blockers in patients with heart failure | 期刊论文 | Huang Jin;Li Chenze;Song Ying;Fan Xiaohan;You Ling;Tan Lun;Xiao Lei;Li Qing;Ruan Guoran;Hu Senlin;Cui Wei;Li Zongzhe;Ni Li;Chen Chen;Woo Anthony Yiu-Ho;Xiao Rui-Ping;Wang Dao Wen |
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