核磁中等交换极限下蛋白-先导化合物低丰度结合态结构表征新方法
21874123
2018
B0403.谱学方法与理论
阮科
面上项目
教授
中国科学技术大学
66万元
核磁共振波谱;低丰度构象;顺磁共振;结构生物学;基于片段的药物先导化合物发现
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Identification of Novel Hits of the NSD1 SET Domain by NMR Fragment-Based Screening | 期刊论文 | Heng Tang;Nshogoza Gilbert;Mingqing Liu;Yaqian Liu;Ke Ruan;Rong-sheng Ma;Jia Gao |
| 2 | Two Binding Sites of SARS-CoV-2 Macrodomain 3 Probed by Oxaprozin and Meclomen | 期刊论文 | Jiao Li;Fumei Zhong;Mingwei Li;Yaqian Liu;Lei Wang;Mingqing Liu;Fudong Li;Jiahai Zhang;Jihui Wu;Yunyu Shi;Zhiyong Zhang;Xiaoming Tu;Ke Ruan;Jia Gao |
| 3 | 抑制G3BP1应激颗粒形成的化合物、制备方法及其用途 | 专利 | 张家海;樊伟伟;李彦;呼朵朵;王细胜;阮科;杨振业;侯中怀 |
| 4 | 王天眷波谱学奖 | 奖励 | 阮科 |
| 5 | Driving force of biomolecular liquid-liquid phase separation probed by nuclear magnetic resonance spectroscopy | 期刊论文 | Zhang Hanyu;Fan Weiwei;Nshogoza Gilbert;Liu Yaqian;Gao Jia;Wu Jihui;Shi Yunyu;Tu Xiaoming;Zhang Jiahai;Ruan Ke |
| 6 | Structural insight into the unique ds DNA binding topology of the human ORC 2 wing helix domain | 期刊论文 | Jiahai Zhang;Qiong Guo;Jun Gao;Chao Xu;Beibei Zhang;Mingwei Li;Jiaqi She;Yunyu Shi;Zhiyong Zhang;Ke Ruan;Jihui Wu |
| 7 | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1 | 期刊论文 | Mengqi Lv;Jia Gao;Mingwei Li;Rongsheng Ma;Fudong Li;Yaqian Liu;Mingqing Liu;Jian Zhang;Xuebiao Yao;Jihui Wu;Yunyu Shi;Yajun Tang;Yueyin Pan;Zhiyong Zhang;Ke Ruan |
| 8 | Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy | 期刊论文 | Lei Wang;Jia Gao;Rongsheng Ma;Yaqian Liu;Mingqing Liu;Fumei Zhong;Jie Hu;Shuju Li;Jihui Wu;Hualiang Jiang;Jiahai Zhang;Ke Ruan |
| 9 | NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43 | 期刊论文 | Gilbert Nshogoza;Yaqian Liu;Jia Gao;Mingqing Liu;Sayed Ala Moududee;Rongsheng Ma;Fudong Li;Jian Zhang;Jihui Wu;Yunyu Shi;Ke Ruan |
| 10 | 具有抗增殖活性的抑制剂 | 专利 | 张家海;金若星;边康杰;汪锐;刘亚茜;王细胜;阮科;刘丹;陈宇星 |
| 11 | Fragment-Based Discovery of AF9 YEATS Domain Inhibitors | 期刊论文 | Yaqian Liu;Ruoxing Jin;Hui Lu;Kangjie Bian;Rui Wang;Lei Wang;Rui Gao;Jiahai Zhang;Jihui Wu;Xuebiao Yao;Xing Liu;Dan Liu;Xisheng Wang;Zhiyong Zhang;Ke Ruan |
| 12 | Structural Basis of Biomolecular Interactions Studied by NMR Spectroscopy | 专著 | Ke Ruan;Jihui Wu;Yunyu Shi |
| 13 | Repurposing Low-Molecular-Weight Drugs against the Main Protease of Severe Acute Respiratory Syndrome Coronavirus 2 | 期刊论文 | Jia Gao;Liang Zhang;Xing Liu;Fudong Li;Rongsheng Ma;Zhongliang Zhu;Jian Zhang;Jihui Wu;Yunyu Shi;Yueyin Pan;Yushu Ge;Ke Ruan |
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