多突变基因调控技术构建iPSCs来源的肝癌体内外模型及其机制研究
81872508
2018
H1826.肿瘤学研究新技术与新方法
朱继业
面上项目
教授
北京大学
57万元
突变基因;C09_肝和肝内胆管肿瘤;诱导多潜能干细胞;人源化动物模型;规律成簇的间隔短回文重复
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro | 期刊论文 | Changkun Zhang;Yang Wang;Xiaodong Xun;Siqi Wang;Xiao Xiang;Shihua Hu;Qian Cheng;Jinghang Guo;Zhao Li;Jiye Zhu |
| 2 | IDH Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic Cholangiocarcinoma | 期刊论文 | Xiao Xiang;Ziyang Liu;Chong Zhang;Zhao Li;Jie Gao;Changkun Zhang;Qi Cao;Jinghui Cheng;Hengkang Liu;Dingbao Chen;Qian Cheng;Ning Zhang;Ruidong Xue;Fan Bai;Jiye Zhu |
| 3 | Liver tumour immune microenvironment subtypes and neutrophil heterogeneity | 期刊论文 | Ruidong Xue;Qiming Zhang;Qi Cao;Ruirui Kong;Xiao Xiang;Hengkang Liu;Mei Feng;Fangyanni Wang;Jinghui Cheng;Zhao Li;Qimin Zhan;Mi Deng;Jiye Zhu;Zemin Zhang;Ning Zhang |
| 4 | Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma | 期刊论文 | Shuo Feng;Xiaoqing Meng;Zhao Li;Tse-Shao Chang;Xiaoli Wu;Juan Zhou;Bishnu Joshi;Eun-Young Choi;Lili Zhao;Jiye Zhu;Thomas D. Wang |
| 5 | NKG2D Enhances Double-Negative T Cell Regulation of B Cells | 期刊论文 | Shi-hua Hu;Long-hui Zhang;Jie Gao;Jing-heng Guo;Xiao-dong Xun;Xiao Xiang;Qian Cheng;Zhao Li;Ji-ye Zhu |
| 6 | Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization. | 期刊论文 | Xiaodong Xun;Changkun Zhang;Siqi Wang;Shi-Hua Hu;Xiao Xiang;Qian Cheng;Zhao Li;Yang Wang;Ji-ye Zhu |
| 7 | Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma | 期刊论文 | Shuo Feng;Juan Zhou;Zhao Li;Henry D.Appelman;Lili Zhao;Jiye Zhu;Thomas D.Wang |
| 8 | Liver and spleen stiffness in predicting the recurrence of hepatocellular carcinoma after resection: A comment for moving forward | 期刊论文 | Xiang Xiao;Wang Yang;Mo Dun-Chang;Wang Si-Q;Xun Xiao-Dong;Hu Shi-Hua;Cheng Qian;Li Zhao;Zhu Ji-Ye |
| 9 | Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids | 期刊论文 | Siqi Wang;Yang Wang;Xiaodong Xun;Changkun Zhang;Xiao Xiang;Qian Cheng;Shihua Hu;Zhao Li;Jiye Zhu |
| 10 | WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma | 期刊论文 | Yongjian Li;Qian Cheng;Jie Gao;Zhuomiaoyu Chen;Jingheng Guo;Zuyin Li;Lingyu Tian;Chao Zhang;Yuzi Li;Jiaxi Zheng;Zhao Li;Jiye Zhu |
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