化学小分子探针引导的细胞信号转导途径研究

91213303
2012
B0702.生物分子的化学生物学
姚祝军
重大研究计划
教授
南京大学
1080万元
小分子探针;信号转导通路;靶点;有机合成;药物候选物
2013-01至2015-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Multiplexing of combinatiorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility. 期刊论文 Zhang, D.|Awakawa, T.|Abe, I.|Liu, W.|
2 Pictet–Spengler reaction based biosyntheticmachinery in fungi 期刊论文 Wei Yan,Hui Ming Ge, Gang Wang, Nan Jiang, Ya Ning Mei,|Rong Jiang, Sui Jun Li, Chao Jun Chen, Rui Hua Jiao, Qiang Xu|Seik Weng Ng|Ren Xiang Tan|
3 Cytotoxic constituents from Cryptocarya maclurei. 期刊论文 Wang, T.|Wei, W.|Tan, R.-X.|Ge, H.-M.|
4 CuI-catalyzed and air promoted oxidative cyclization for one-pot synthesis of polyarylated oxazoles 期刊论文 Hu Ping;Wang Qiang;Yan Yizhe;Zhang Shuai;Zhang Baiqun;Wang Zhiyong
5 Cerium(III)-catalyzedcascade cyclization: an efficient approach to functionalizedpyrrolo[1,2-a]quinolines 期刊论文 Chengtao Feng, Yizhe Yan, Zhenglei Zhang, Kun Xu|Zhiyong Wang|
6 New flavonol and diterpenoids from the endophytic fungus Aspergillus sp. YXf3 期刊论文 Song, Y.-C.|Jiao, R.-H.|Tan, R.-X.|Ge, H.-M.|
7 A simple and efficient approach to realize difunctionalization of arylketoneswith malonate esters via an electrochemical oxidation 期刊论文 Huihui Gao, Zhenggen Zha*, Zhenlei Zhang, Huanyue Ma,|Zhiyong Wang|
8 Cyclization of polyketidesand non-ribosomal peptides on and off their assembly lines, 期刊论文 Pang, B.; Wang, M.|Liu, W.|
9 Fluorescence Polarization for the Evaluation of Small-Molecule Inhibitors of PCAF-BRD/Tat-AcK50 Association, Hu, P.; Wang, X.; Zhang, B.; Zhang, S.; Wang Q.;* Wang, Z.* 期刊论文 汪志勇|
10 An enzymatic [4+2]cyclization cascade creates the pentacyclic core of pyrroindomycins 期刊论文 Tian,Z, Sun, P., Yan,Y, Wu, J., Zheng, Q., Zhou,S., Yu,F.,|Chen,D., Mandi, A, Kurtan, T.,|Liu, W.|
11 FK506 maturation involves acytochrome P450 protein-catalyzed four electron oxidation in parallel with C-31O-methylation. 期刊论文 Chen, D.; Zhang, L.; Pang, B.; Chen, J.|Xu, Z.; Abe, I.|Liu, W.|
12 Biosynthesis of thiopeptide antibiotics and their pathway engineering. 期刊论文 Zhang, Q.|Liu, W.|
13 Spiroketal formation andmodification in avermectin biosynthesis involves a dual activity of AveC 期刊论文 Sun, P.; Zhao, Q.; Yu, F.; Zhang, H.|Wu, Z.; Wang, Y-Y.; Wang, Y.|Liu, W.|
14 Copper-catalyzed Ligand-free Amidation of Aryl iodides and Amino AcidAmides to Synthesize C3-(Z)-1H-benzo[e][1,4]diazepin-2(3H)-ones 期刊论文 Xiao Hu, Yi Dong|Gang Liu|
15 Copper-CatalyzedEnantioselective Friedel-Crafts Alkylation of Pyrrole with Isatins 期刊论文 Chong Li, Fengfeng Guo, Kun Xu, Sheng Zhang,|Yanbin Hu, Zhenggen Zha,|Zhiyong Wang|
16 Electrosynthesis of enaminones directly from methylketones and amines with nitromethane as a carbon source 期刊论文 Kun Xu, Zhenlei Zhang, Peng Qian, Zhenggen Zha,|Zhiyong Wang|
17 Electrochemical Synthesis of the Arylα-Ketoesters fromAcetophenones Mediated by KI 期刊论文 Zhenlei Zhang, Jihu Su,|Zhenggen Zha*, Zhiyong Wang*|
18 Insight into bicyclic thiopeptide benifited from development of a uniform approach for molecular engineering and production improvement. 期刊论文 Yu, Y.|Zheng, Q.|Wu, J.|Liu, W.|
19 Metal-Organic Framework with Functional Amide Groupsfor Highly Selective Gas Separation 期刊论文 Shunshun Xiong, Yabing He, Rajamani Krishna,|Banglin Chen*,Zhiyong Wang*|
20 Copper CatalyzedEnantioselective Alkylation of Pyrrole with β,γ-Unsaturated α-Ketoesters:Application to One-Pot Construction of the Seven-Membered Ring by Merging aGold Catalysis 期刊论文 Yanbin Hu, Yanan Li, Sheng Zhang, Chong Li, Lijun Li,|Zhenggen Zha,|Zhiyong Wang|
21 Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons. Fei Xu, Han Zhao, Xiaojun Feng, Linhai Chen, Dongjuan Chen, Yang Zhang, Fajun Nan*, Jianfeng Liu*, Bi-Feng Liu*. 期刊论文 南发俊|
22 Highly Enantioselective Construction of Fluoroalkylated QuaternaryStereocenters viaOrganocatalytic Dehydrated Mannich Reaction ofUnprotected Hemiaminals with Ketones 期刊论文 ShengZhang, Lijun Li, Yanbin Hu, Yanan Li, Yu Yang,|Zhenggen Zha|Zhiyong Wang|
23 Iodine(III)-mediated[3+2] cyclization for one-pot synthesis of benzo[d]isoxazole-4,7-diol,benzodiisoxazole-4,8-diol, isoxazole[5,4-a]phenazine and indazole-4,7-diol inaqueous medium 期刊论文 Yingwei Hou, Shichao Lu|Gang Liu|
24 Regio-controlled synthesis of unsymmetrical pyrazine-fused sinomenine derivatives and discriminate substitution effects on TNF-a inhibitory activity 期刊论文 Zhou T.-T.;Hou J.;Wang M.;Ma L.-Y.;Wu L.-L.;Wang S.-z.;Sun B.; Yao Z.-J.
25 Discovery and efficientsynthesis of a biological active alkaloid inspired by thiostrepton biosynthesis 期刊论文 Zheng Q.;Wang S.;Liu W.
26 Goldnanoparticles supported on titanium dioxide: an efficient catalyst for highlyselective synthesis of benzoxazoles and benzimidazoles 期刊论文 Lin Tang, Xuefeng Guo, Yu Yang, Zhenggen Zha,|Zhiyong Wang|
27 Insight into bicyclic thiopeptide benefited from development of a uniform approach for molecular engineering and production improvement. Guo, H.; Wang, J.; Li, Y.; Yu, Y.; Zheng, Q.; Wu, J.; Liu, W. 期刊论文 刘文|
28 Supportedgold-catalyzed and ammonia-promoted selective synthesis of quinazolines inaqueous media 期刊论文 Lin Tang, Yu Yang, Lixian Wen, Sheng Zhang, Zhenggen Zha,|Zhiyong Wang|
29 Modified Calanolides incorporated with furan-2-nitro mimics againstMycobacterium tuberculosis 期刊论文 Zijie Liu, Xiaoyong Guo|Gang Liu|
30 Bifunctional Amino Sulfonohydrazide Catalyzed Direct Asymmetric MannichReaction of Cyclic Ketimines with Ketones: Highly Diastereo- andEnantioselective Construction of Quaternary Carbon Stereocenters 期刊论文 Sheng Zhang, Lijun Li, Yanbin Hu, Zhenggen Zha,|Zhiyong Wang,Teck-PengLoh*,|
31 Oxidative coupling of methylamine with an aminylradical: direct amidation catalyzed by I2/TBHP with HCl 期刊论文 Lingfeng Gao, Haoming Tang,|Zhiyong Wang|
32 Cyclization of polyketidesand non-ribosomal peptides on and off their assembly linesEffect of Stereochemistryof Avermectin-Like 6,6-Spiroketals on Biological Activities and EndogenousBiotransformations in Streptomycesavermectinius 期刊论文 Sun, P.; Zhao, Q.; Zhang, H.; Wu, J.|Liu, W.|
33 Curvulamine, a Novel Antibacterial Alkaloid with New Extender Units from Curvularia sp. IFB-Z10. Wen Bo Han, Yan Hua Lu, Ai Hua Zhang, Gao Fei Zhang, Ya Ning Mei, Na Jiang, Xinxiang Lei, Yong Chun Song, Seik Weng Ng, and Ren Xiang Tan*. 期刊论文 谭仁祥|
34 A novel approach for the one-pot preparation of α-ketoamides by anodic oxidation 期刊论文 Zhenlei Zhang, Jihu Su, Zhenggen Zha*|Zhiyong Wang*|
35 Small organic molecules targeting PCAF bromodomin as potent inhibitors of HIV-1 replication. 期刊论文 Zhang, B. Q.|Zhang, S.|Zheng, Y. T.|Wang, Z. Y.|
36 Electrosynthesis of oxadiazoles from benzoylhydrazines 期刊论文 Ma Huan-Yue;Zha Zheng-Gen;Zhang Zhen-Lei;Meng Li;Wang Zhi-Yong
37 Discovery of a Negative Allosteric Modulator of GABAB Receptors. Lin-Hai Chen, Sun Bing, Yang Zhang, Tong-Jie Xu, Zhi-Xiong Xia, Jian-Feng Liu*, Fa-Jun Nan*. 期刊论文 南发俊|
38 An efficient synthesis of amides from alcohols andazides catalyzed by a bifunctional catalyst Au/DNA under mild conditions 期刊论文 Xuefeng Guo, Lin Tang, Yu Yang, Zhenggen Zha,|Zhiyong Wang|
39 Targeting the γ-/β-secretase interaction reducesβ-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis 期刊论文 Cui, J.; Wang, X.; Li, X.; Wang, X.; Zhang, C.; Li, W.|Zhang, Y.; Gu, H.; Xie, X.|Nan, F.|Zhao, J.; Pei, G.|
40 Copper/Silver-MediatedCascade Reactions for the Construction of 2-Sulfonylbenzo[b]furans from trans-2-HydroxycinnamicAcids and Sodium Sulfinates 期刊论文 Hong-Shuang Li|Gang Liu|
41 Opportunities and challenges from current invetigations into the biosynthetic logic of nosiheptide-represented thiopeptide antibiotics. 期刊论文 Wang, S.|Zhou, S.|Liu, W.|
42 Agreen and efficient access to aryl nitriles via an electrochemical anodicoxidation 期刊论文 Jia-Qian Ye, Zhenlei Zhang,|Zhenggen Zha*, Zhiyong Wang*|
43 Bismuth nanoparticles: an efficient catalyst for reductive coupling of nitroarenes toazo-compounds 期刊论文 Kishore Pothula,Lin Tang,Zhenggen Zha,|Zhiyong Wang|
44 Synthesisof benzofused five-ring sultams via Rh-catalyzed CH olefination directed by anN-Ac substituted sulfonamide group 期刊论文 Xueyuan Li, Yi Dong,|Fengyu QU*, Gang Liu*|
45 Copper-CatalyzedEnantioselective Hetero-Diels-Alder Reaction of Danishefsky?’s Diene withβ,γ-Unsaturated α-Ketoesters 期刊论文 Yanbin Hu, Kun Xu, Sheng Zhang, Fengfeng Guo, Zhenggen Zha|Zhiyong Wang|
46 Synthesis of Chromones through LiOtBu/Air-Mediated Oxidation and Regioselective Cyclization of o-Hydroxyphenyl Propargyl Carbinols 期刊论文 Zhang, Baiqun|Gao, Lingfeng|Zha, Zhenggen|Wang, Zhiyong|
47 Aromatic PolyketidesProduced by Bacterial Iterative Type I Polyketide Synthases 期刊论文 Zhang, Q.; Pang, B.; Ding, W.|Liu, W.|
48 Cobalt-catalyzed oxidative [3 + 2] cycloaddition reactions: an efficient synthesis of pyrrolo- and imidazo-[2,1-a]isoquinolines 期刊论文 Chengtao Feng|Jihu Su|Yizhe Yan|Fengfeng Guo|Zhiyong Wang*|
49 Direct Electrosynthesis of Ketones from Benzylic Methylenes by Electrooxidative CH Activation 期刊论文 Li Meng, Jihu Su, Zhenggen Zha* Li Zhang|Zhenlei Zhang, Zhiyong Wang*|
50 Antitumor effect of naturally occurring oligomeric resveratrol derivatives. 期刊论文 Zhao, G.|Hou, Y.|Ge, H. M.|Tan, R. X.|
51 Thiopeptide AntibioticsExhibit a DualModeof Action against Intracellular Pathogens by Affecting BothHost and Microbe 期刊论文 Zheng, Q.; Wang, Q.; Wang, S.|Wu, J.; Gao, Q.|Liu, W.|
52 Regio-controlled synthesis of unsymmetrical pyrazine-fused sinomenine derivatives and discriminate substitution effects on TNF-α inhibitory activity. Zhou, T.-T.; Hou, J.; Wang, M.; Ma, L.-Y.; Wu, L.-L.; Wang, S.-M.; Sun, B.*; Yao, Z.-J.* 期刊论文 姚祝军|
53 基于活性小分子探针的蛋白质标记基于活性小分子探针的蛋白质标记 (第9章),化学生物学前沿与展望(蒋华良等编) 期刊论文 南发俊|
54 Copper-CatalyzedRadical Methylation/C-H Amination/Oxidation Cascade for the Synthesis ofQuinazolinones 期刊论文 Yajie Bao, Yizhe Yan, Kun Xu, Jihu Su,|Zhenggen Zha,|Zhiyong Wang|
55 Cross-couplingtype tandem chloropalladation/dearomative cyclization towards functionalizedbridged [3.2.1] skeleton compounds 期刊论文 Yi Dong, Nana Du, Xueyuan Li, Litao Zheng,|Gang Liu|
56 Highly Diastereo- and Enantioselective Michael Addition of Nitroalkanes to2-Enoyl-Pyridine N-Oxides Catalyzed by Scandium(III)/Copper(II) Complexes 期刊论文 Lijun Li, Sheng Zhang, Yanbin Hu, Yanan Li,|Chong Li, Zhenggen Zha,|Zhiyong Wang|
57 Benzothiazoles exhibit broad-spectrum antitumor activity: their potency, structure-activity and structure-metabolism relationships. Xie X, Yan Y, Zhu N, Liu G. 期刊论文 刘刚|
58 Fumigaclavines D–H, New Ergot Alkaloids from Endophytic Aspergillus fumigatus. Jing Xu, Yong Chun Song, Ye Guo, Ya Ning Mei, Ren Xiang Tan*. 期刊论文 谭仁祥|
59 Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylicC-H aminations of methylarenes 期刊论文 Liyan Liu, Yizhe Yan, Yajie Bao,|Zhiyong Wang|
60 Catalyst-freesulfonylation of activated alkenes for highly efficient synthesis ofmono-substituted ethyl sulfones in water 期刊论文 Yu Yang, Lin Tang, Sheng Zhang, Xuefeng Guo, Zhenggen Zha|Zhiyong Wang|
61 Metabolic coupling of twosmall-molecule thiols programs the biosynthesis of lincomycin A 期刊论文 Zhao, Q., Wang,M., Xu,D., Zhang,Q.|Liu, W.|
查看更多信息请先登录或注册