链霉菌多效调控子—WblA激活隐性抗生素合成基因簇 (tyl)的分子机制

31771378
2017
C0602.基因表达及非编码序列调控
谭华荣
面上项目
研究员
中国科学院微生物研究所
65万元
次级代谢产物;启动子;基因簇;转录调控;细菌
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Component optimization of neomycin biosynthesis via the reconstitution of a combinatorial mini-nene-cluster in Streptomyces fradiae 期刊论文 Zheng Jiazhen;Li Yue;Guan Hanye;Li Junyue;Li Dong;ZHang Jihui;Tan Huarong
2 Enhancement of neomycin production by engineering the entire biosynthetic gene cluster and feeding key precursors in Streptomyces fradiae CGMCC 4.576. 期刊论文 Zheng Jiazhen;Li Yue;Guan Hanye;Zhang Jihui;Tan Huarong
3 Important role of a LAL regulator StaR in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576 期刊论文 Guan Hanye;Li Yue;Zheng Jiazhen;Liu Ning;Zhang Jihui;Tan Huarong
4 A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules. 期刊论文 Liu Xiang;Wang Wenxi;Li Junyue;Li Yue;Zhang Jihui;Tan Huarong
5 Co-expression of a SARP family activator ChlF2 with a type II thioesterase ChlK led to high-production of chlorothricin in Streptomyces antibioticus DSM 40725 期刊论文 Li Yue;Zhang Jihui;Zheng Jiazhen;Guan Hanye;Liu Wen;Tan Huarong
6 Activation of cryptic antibiotic biosynthetic gene clusters guided by RNA-seq data from both Streptomyces ansochromogenes and ΔwblA. 期刊论文 Li Yue;Yu Haiying;Guan Hanye;Li Jingjing;Zhang Jihui;Xiang Hua;Li Jine;Tan Huarong
7 Reconstruction of a mini-gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus 期刊论文 Li Dong;Tian Yuqing;Liu Xiang;Wang Wenxi;Li Yue;Tan Huarong;Zhang Jihui
8 Enhancement of salinomycin production by ribosome engineering in Streptomyces albus 期刊论文 Li Dong;Zhang Jihui;Tian Yuqing;Tan Huarong
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