FGFR3在调节生长板软骨发育及软骨瘤样发育畸形中作用与机制研究
81530071
2015
H06.运动系统
陈林
重点项目
研究员
中国人民解放军第三军医大学
274万元
发育;成纤维细胞生长因子受体3;疾病;生长板;小鼠模型
2016-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | FGF信号在骨骼发育及骨病中的作用与机制研究 | 奖励 | 陈林;王铸钢;苏楠;谢杨丽;杜晓兰 |
| 2 | Pulsed Electromagnetic Field Inhibits Synovitis via Enhancing the Efferocytosis of Macrophages | 期刊论文 | Ouyang Junjie;Zhang Bin;Kuang Liang;Yang Peng;Du Xiaolan;Qi Huabin;Su Nan;Jin Min;Yang Jing;Xie Yangli;Tan Qiaoyan;Chen Hangang;Chen Shuai;Jiang Wanling;Liu Mi;Luo Xiaoqing;He Mei;Ni Zhenhong;Chen Lin |
| 3 | PTH 1-34 Ameliorates the Osteopenia and Delayed Healing of Stabilized Tibia Fracture in Mice with Achondroplasia Resulting from Gain-Of-Function Mutation of FGFR3 | 期刊论文 | Chen Hangang;Sun Xianding;Yin Liangjun;Chen Shuai;Zhu Ying;Huang Junlan;Jiang Wanling;Chen Bo;Zhang Ruobin;Chen Lin;Nie Mao;Xie Yangli;Deng Zhongliang |
| 4 | Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/beta-catenin signaling | 期刊论文 | Sun Xianding;Zhang Ruobin;Chen Hangang;Du Xiaolan;Chen Shuai;Huang Junlan;Liu Mi;Xu Meng;Luo Fengtao;Jin Min;Su Nan;Qi Huabing;Yang Jing;Tan Qiaoyan;Zhang Dali;Ni Zhenhong;Liang Sen;Zhang Bin;Chen Di;Zhang Xin;Luo Lingfei;Chen Lin;Xie Yangli |
| 5 | FGF/FGFR signaling in health and disease. | 期刊论文 | Xie Yangli;Su Nan;Yang Jing;Tan Qiaoyan;Huang Shuo;Jin Min;Ni Zhenhong;Zhang Bin;Zhang Dali;Luo Fengtao;Chen Hangang;Sun Xianding;Feng Jian Q;Qi Huabing;Chen Lin |
| 6 | Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy | 期刊论文 | Yin Jie;Yang Lele;Xie Yangli;Liu Yan;Li Sheng;Yang Wenjun;Xu Bo;Ji Hongbin;Ding Lianghua;Wang Kun;Li Gang;Chen Lin;Hu Ping |
| 7 | FGFR3 deficient mice have accelerated fracture repair | 期刊论文 | Xie Yangli;Luo Fengtao;Xu Wei;Wang Zuqiang;Sun Xianding;Xu Meng;Huang Junlan;Zhang Dali;Tan Qiaoyan;Chen Bo;Jiang Wanling;Du Xiaolan;Chen Lin |
| 8 | The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1 beta production of macrophages and aggravated synovitis in osteoarthritis | 期刊论文 | Ni Zhenhong;Kuang Liang;Chen Hangang;Xie Yangli;Zhang Bin;Ouyang Junjie;Wu Jiangyi;Zhou Siru;Chen Liang;Su Nan;Tan QiaoYan;Luo Xiaoqing;Chen Bo;Chen Shuai;Yin Liangjun;Huang Haiyang;Du Xiaolan;Chen Lin |
| 9 | Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway | 期刊论文 | Sun Xianding;Zhou Yang;Zhang Ruobin;Wang Zuqiang;Xu Meng;Zhang Dali;Huang Junlan;Luo Fengtao;Li Fangfang;Ni Zhenhong;Zhou Siru;Chen Hangang;Chen Shuai;Chen Liang;Du Xiaolan;Chen Bo;Huang Haiyang;Liu Peng;Yin Liangjun;Qiu Juhui;Chen Di;Deng Chuxia;Xie Yangli;Luo Lingfei;Chen Lin |
| 10 | Chondrocyte FGFR3 Regulates Bone Mass by Inhibiting Osteogenesis | 期刊论文 | Wen Xuan;Li Xiaogang;Tang Yubin;Tang Junzhou;Zhou Siru;Xie Yangli;Guo Jingyuan;Yang Jing;Du Xiaolan;Su Nan;Chen Lin |
| 11 | Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint | 期刊论文 | Wang Zuqiang;Huang Junlan;Zhou Siru;Luo Fengtao;Tan Qiaoyan;Sun Xianding;Ni Zhenhong;Chen Hangang;Du Xiaolan;Xie Yangli;Chen Lin |
| 12 | 便携可调式低强度脉冲超声治疗仪 | 专利 | 陈林;杜晓兰;刘汨;谢杨丽;杨京;蒋宛凌;陈涵纲;罗凤涛;王祖强 |
| 13 | 调节FGFR1活性的多肽及其应用 | 专利 | 陈林;谭乔燕;金旻;杜晓兰;王晓凤;王权;徐伟;王先行 |
| 14 | Skeletal muscle regeneration is modulated by inflammation | 期刊论文 | Yang Wenjun;Hu Ping |
| 15 | FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice | 期刊论文 | Kuang Liang;Wu Jiangyi;Su Nan;Qi Huabing;Chen Hangang;Zhou Siru;Xiong Yan;Du Xiaolan;Tan Qiaoyan;Yang Jing;Jin Min;Luo Fengtao;Ouyang Junjie;Zhang Bin;Wang Zuqiang;Jiang Wanling;Chen Liang;Chen Shuai;Wang Ziming;Liu Peng;Yin Liangjun;Guo Fengjin;Deng Chuxia;Chen Di;Liu Chuanju;Xie Yangli;Ni Zhenhong;Chen Lin |
| 16 | 小鼠关节软骨表层细胞分离培养及鉴定 | 期刊论文 | 谭乔燕;王权;旷梁;谢杨丽;李灿;罗凤涛;杜晓兰;陈林 |
| 17 | 关节软骨干/祖细胞治疗关节软骨缺损研究进展 | 期刊论文 | 谭乔燕;李灿;谢杨丽;罗凤涛;杜晓兰;陈林 |
| 18 | p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice | 期刊论文 | Yi Young Su;Jian Jinlong;Gonzalez Gugel Elena;Shi Yong Xiang;Tian Qingyun;Fu Wenyu;Hettinghouse Aubryanna;Song Wenhao;Liu Ronghan;He Michun;Qi Huabing;Yang Jing;Du Xiaolan;Xiao GuoZhi;Chen Lin;Liu Chuan Ju |
| 19 | 低强度脉冲超声调控滑膜巨噬细胞极化抑制关节滑膜炎 | 期刊论文 | 张斌;倪振洪;杨鹏;旷梁;欧阳俊杰;谢杨丽;蒋宛凌;刘汨;杜晓兰;陈林 |
| 20 | Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies | 期刊论文 | Bosakova Michaela Kunova;Varecha Miroslav;Hampl Marek;Duran Ivan;Nita Alexandru;Buchtova Marcela;Dosedelova Hana;Machat Radek;Xie Yangli;Ni Zhenhong;Martin Jorge H;Chen Lin;Jansen Gert;Krakow Deborah;Krejci Pavel |
| 21 | Deletion of FGFR3 in Osteoclast Lineage Cells Results in Increased Bone Mass in Mice by Inhibiting Osteoclastic Bone Resorption | 期刊论文 | Su Nan;Li Xiaogang;Tang Yubin;Yang Jing;Wen Xuan;Guo Jingyuan;Tang Junzhou;Du Xiaolan;Chen Lin |
| 22 | New insights on the reparative cells in bone regeneration and repair. | 期刊论文 | Huang Shuo;Jin Min;Su Nan;Chen Lin |
| 23 | A novel FGFR1-binding peptide attenuates the degeneration of articular cartilage in adult mice | 期刊论文 | Tan Q.;Chen B.;Wang Q.;Xu W.;Wang Y.;Lin Z.;Luo F.;Huang S.;Zhu Y.;Su N.;Jin M.;Li C.;Kuang L.;Qi H.;Ni Z.;Wang Z.;Luo X.;Jiang W.;Chen H.;Chen S.;Li F.;Zhang B.;Huang J.;Zhang R.;Jin K.;Xu X.;Deng C.;Du X.;Xie Y.;Chen L. |
| 24 | SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1 beta and contributes to LIPUS-mediated anti-inflammatory effect | 期刊论文 | Zhang Bin;Chen Hangang;Ouyang Junjie;Xie Yangli;Chen Liang;Tan Qiaoyan;Du Xiaolan;Su Nan;Ni Zhenhong;Chen Lin |
| 25 | 生长板损伤修复的研究进展 | 期刊论文 | 谢杨丽;谭乔燕;罗凤涛;李灿;黄俊兰;杜晓兰;陈林 |
| 26 | Effects and Mechanisms of Exogenous Electromagnetic Field on Bone Cells: A Review. | 期刊论文 | Zhang Bin;Xie Yangli;Ni Zhenhong;Chen Lin |
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