FoxO1表达与表观遗传修饰在胰岛β细胞衰老和功能障碍中的作用及其机制

91749101
2017
H0708.糖尿病
洪天配
重大研究计划
教授
北京大学
60万元
胰岛β细胞;表观遗传修饰;细胞衰老;糖尿病;FoxO1
2018-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output 期刊论文 Liu J;Yang K;Yang J;Xiao W;Le Y;Yu F;Gu L;Lang S;Tian Q;Jin T;Wei R;Hong T
2 Liraglutide ameliorates palmitate-induced oxidative injury in islet microvascular endothelial cells through GLP-1 receptor/PKA and GTPCH1/eNOS signaling pathways 期刊论文 Le Y;Wei R;Yang K;Lang S;Gu L;Liu J;Hong T;Yang J
3 Glucagon receptor antagonism increases mouse pancreatic delta-cell mass through cell proliferation and duct-derived neogenesis 期刊论文 Gu L;Cui X;Lang S;Wang H;Hong T;Wei R
4 High baseline FGF21 levels are associated with poor glucose-lowering eicacy of exenatide in patients with type 2 diabetes 期刊论文 Yang K;Wang H;Wei R;Xiao W;Tian Q;Wang C;Yang J;Hong T
5 Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes 期刊论文 Lang S;Yang J;Yang K;Gu L;Cui X;Wei T;Liu J;Le Y;Wang H;Wei R;Hong T
6 Molecular imaging of diabetes and diabetic complications: Beyond pancreatic beta-cell targeting 期刊论文 Yang J;Zhang L;Wang F;Hong T;Liu Z
7 肠道胰高糖素原衍生肽在血糖稳态调控和糖尿病治疗中的作用 期刊论文 郎杉;洪天配;魏蕊
8 MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity 期刊论文 Si W;Liu X;Wei R;Zhang Y;Zhao Y;Cui L;Hong T
9 Synergistic anti-tumor effects of liraglutide with metformin on pancreatic cancer cells 期刊论文 Lu R;Yang J;Wei R;Ke J;Tian Q;Yu F;Liu J;Zhang J;Hong T
10 Myopathy after rapid correction of hyperthyroidism A case report and review of literature 期刊论文 Lu R;Wang H;Hong T;Gao H
11 Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice. 期刊论文 Wei R;Cui X;Feng J;Gu L;Lang S;Wei T;Yang J;Liu J;Le Y;Wang H;Yang K;Hong T
12 我国GLP-1受体激动剂治疗糖尿病的临床与基础研究 期刊论文 刘珺玲;魏蕊;洪天配
13 Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice 期刊论文 Lang S;Wei R;Wei T;Gu L;Feng J;Yan H;Yang J;Hong T
14 肠促胰素效应的发现及其临床应用展望 期刊论文 洪天配;田勍;杨进
15 GLP-1 receptor agonists stimulate ANGPTL8 production through the PI3K/Akt pathway in a GLP-1 receptor-dependent manner 期刊论文 Liu J;Yang K;Xiao W;Le Y;Lang S;Zhang J;Wei R;Yang J;Hong T
16 胰岛α细胞功能和表型变化在糖尿病治疗学中的重要意义 期刊论文 魏蕊;洪天配
17 Antagonistic Glucagon Receptor Antibody Promotes alpha-Cell Proliferation and Increases beta-Cell Mass in Diabetic Mice 期刊论文 Wei R;Gu L;Yang J;Yang K;Liu J;Le Y;Lang S;Wang H;Thai D;Yan H;Hong T
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