锌转运体ZnT3通过调节突触锌离子释放参与tau蛋白磷酸化的分子机制研究

31371091
2013
C0901.分子与细胞神经生物学
王占友
面上项目
教授
东北大学
88万元
tau蛋白;基因敲除小鼠;阿尔茨海默病;突触锌离子释放;锌转运体
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1 beta and A beta between glial and neuron cells 期刊论文 Wang Pu;Guan Pei-Pei;Wang Tao;Yu Xin;Guo Jian-Jun;Wang Zhan-You
2 Erythrocyte membrane-encapsulated celecoxib improves the cognitive decline of Alzheimer's disease by concurrently inducing neurogenesis and reducing apoptosis in APP/PS1 transgenic mice. 期刊论文 Guo Jing-Wen;Guan Pei-Pei;Ding Wei-Yan;Wang Si-Ling;Huang Xue-Shi;Wang Zhan-You;Wang Pu
3 By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization 期刊论文 Guan Pei-Pei;Yu Xin;Guo Jian-Jun;Wang Yue;Wang Tao;Li Jia-Yi;Konstantopoulos Konstantinos;Wang Zhan-You;Wang Pu
4 Disruption of brain zinc homeostasis promotes the pathophysiological progress of Alzheimer's disease 期刊论文 Li Lin-Bo;Wang Zhan-You
5 一种细胞间接共培养支架 专利 李丹丹;赵蒲;王占友
6 Prostaglandin I(2) Attenuates Prostaglandin E(2)-Stimulated Expression of Interferon gamma in a beta-Amyloid Protein- and NF-kappaB-Dependent Mechanism. 期刊论文 Wang Pu;Guan Pei-Pei;Yu Xin;Zhang Li-Chao;Su Ya-Nan;Wang Zhan-You
7 The Role of Cyclooxygenase-2, Interleukin-1 beta and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage 期刊论文 Guan Pei-Pei;Guo Jing-Wen;Yu Xin;Wang Yue;Wang Tao;Konstantopoulos Konstantinos;Wang Zhan-You;Wang Pu
8 Magnesium ion influx reduces neuroinflammation in A beta precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1 beta 期刊论文 Wang Pu;Yu Xin;Guan Pei-Pei;Guo Jing-Wen;Wang Yue;Zhang Yan;Zhao Hang;Wang Zhan-You
9 COX-2 metabolic products, the prostaglandin I2 and F2alpha, mediate the effects of TNF-alpha and Zn(2+) in stimulating the phosphorylation of Tau. 期刊论文 Wang Yue;Guan Pei-Pei;Yu Xin;Guo Yan-Su;Zhang Ying-Jie;Wang Zhan-You;Wang Pu
10 Prostaglandin I-2 upregulates the expression of anterior pharynx-defective-1 and anterior pharynx-defective-1 in amyloid precursor protein/presenilin 1 transgenic mice 期刊论文 Wang Pu;Guan Pei-Pei;Guo Jing-Wen;Cao Long-Long;Xu Guo-Biao;Yu Xin;Wang Yue;Wang Zhan-You
11 Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease 期刊论文 Wang Pu;Wang Zhan-You
12 By suppressing the expression of anterior pharynx-defective-1 alpha and-1 beta and inhibiting the aggregation of beta-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice 期刊论文 Yu Xin;Guan Pei-Pei;Guo Jing-Wen;Wang Yue;Cao Long-Long;Xu Guo-Biao;Konstantopoulos Konstantinos;Wang Zhan-You;Wang Pu
13 Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice 期刊论文 Zhang Shuai;Chai Rui;Yang Ying-Ying;Guo Shi-Qi;Wang Shan;Guo Tian;Xu Shuang-Feng;Zhang Yan-Hui;Wang Zhan-You;Guo Chuang
14 Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model. 期刊论文 Guo Chuang;Zhang Shuai;Li Jia-Yi;Ding Chen;Yang Zhao-Hui;Chai Rui;Wang Xu;Wang Zhan-You
15 Intranasal Lactoferrin Enhances alpha-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1alpha Pathways in an Alzheimer's Disease Mouse Model. 期刊论文 Guo Chuang;Yang Zhao-Hui;Zhang Shuai;Chai Rui;Xue Han;Zhang Yan-Hui;Li Jia-Yi;Wang Zhan-You
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