针对CKLF1与趋化因子受体的相互作用设计、发现和获取小分子化合物及其炎症干预作用的研究

90813025
2008
C0807.生殖免疫与移植免疫
王应
重大研究计划
教授
北京大学
50万元
趋化因子受体;CKLF1;小分子化合物;炎症;拮抗作用。
2009-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Synthesis of thiourea derivatives as CCR4 antagonists 期刊论文 Xiao, Jun Hai|Wang, Ying|Zhao, Fang|Li, Song|
2 Potent antitumor activities of recombinant human PDCD5 protein in combination with chemotherapy drugs in K562 cells 期刊论文 Lou, Yaxin|Tian, Linjie|Zhang, Yingmei|Zheng, Yi|Ke, Xiaoyan|Wang, Ying|Song, Quansheng|Shi, Lin|Ma, Dalong|Wang, Yanfang|
3 Screening of thiourea derivatives and carbonyl-2-aminothiazole derivatives for potential CCR4 antagonists using capillary zone electrophoresis. 期刊论文 王应|
4 芳酰胺基噻唑类衍生物的合成及其CCR4趋化抑制活性研究 期刊论文 王应|李松|赵芳|肖军海|
5 Alleviation of murine allergic rhinitis by C19, a C-terminal peptide of chemokine-like factor 1 (CKLF1). 期刊论文 王应|
6 Interactions of Peptides from Secreted Human CKLF1 and the N-Terminal Extracellular Tail of CCR4 Analyzed by CZE 期刊论文 Wang, Ying|Zhang, Yingmei|Ling, Xiaomei|Tian, Linjie|Sun, Zhe|
7 Rat CC chemokine receptor 4 is the functional homologue of human CC chemokine receptor 4 and can interact with human CCL17 and CCL22 期刊论文 Tian LinJie|Wang Ying|Zhang YingMei|Zhang WenJuan|Qi Hui|Xie Yuan|Ma DaLong|Sun XiangYu|
8 C-terminal peptides of Chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4. 期刊论文 王应|
9 The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4- mediated chemotaxis in a mouse model of asthma. 期刊论文 王应|
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