白血病状态下造血微环境的改变及机制研究

81090412
2010
H0801.造血、造血调控与造血微环境
诸江
重大项目
研究员
上海交通大学
185万元
白血病；造血干/祖细胞；造血微环境；分子机制
2011-01至2014-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF 期刊论文 Wei Gao|Lihong Wang|Qinghua Li|Guoqiang Chang|Li Ma|Yani Lin|Weina Jin|Huawen Li|Jian Wang|Tianxiang Pang|
2 Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment 期刊论文 Tian C|Zheng GG|Cao ZP| Li Q|Ju ZY| Wang JH|Yuan WP|Cheng T|
3 Functional expression of P2X family receptors in macrophages is affected by microenvironment in mouse T cell acute lymphoblastic leukemia 期刊论文 Chen Shayan;Feng Wenli;Yang Xiao;Yang Wanzhu;Ru Yongxin;Liao Jinfeng;Wang Lina;Lin Yongmin;Ren Qian;Zheng Guoguang
4 NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP 期刊论文 Qinghua Li|Li Ma|Tianxiang Pang|Weina Jin|Lihong Wang|Jian Wang|Huawen Li|Guoqiang Chang|Yani Lin|
5 Neutrophil gelatinase–associated lipocalin regulates intracellular accumulation of Rh123 in cancer cells 期刊论文 Zhang HJ| Wang J| Lin YN| Ji WN| Li HW|Gao W|Wang RJ|Li QH|Pang TX|
6 Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance , quiescence and niche interaction 期刊论文 JY Wang|P Yu|S Chen|H Xing|Y Chen|M Wang...|
7 NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP 期刊论文 Lihong Wang|Jian Wang|Li Ma|Weina Jin|Qinghua Li|Huawen Li|Yani Lin|Tianxiang Pang|
8 RIG-I Modulates Src-Mediated AKT Activation to Restrain Leukemic Stemness 期刊论文 Li Xian Yang;Jiang Lin Jia;Chen Lei;Ding Meng Lei;Guo He Zhou;Zhang Wu;Zhang Hong Xin;Ma Xiao Dan;Liu Xiang Zhen;Xi Xiao Dong;Chen Sai Juan;Chen Zhu;Zhu Jiang
9 Reversal of Imatinib resistance in BCR-ABL-positive leukemia after inhibition of the Na+/H+ exchanger 期刊论文 Yani Lin|Jianxiang Wang|Ying Lu|Li Ma|Tianxiang Pang|Ronghua Hu|Qinghua Li,|Lihong Wang|Weina Jin|Huawen Li|
10 CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment 期刊论文 Jiang Li;Liu Jian-Feng;Sun Dongxiao;Ma Peipei;Ding Xiangdong;Yu Ying;Zhang Qin
11 Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation 期刊论文 Jia Yujiao;Peng Leiwen;Rao Qing;Xing Haiyan;Huai Lei;Yu Pei;Chen Yirui;Wang Cuicui;Wang Min;Mi Yingchang;Wang Jianxiang
12 Cariporide sensitizes leukemic cells to tumor necrosis factor related apoptosis-inducing ligand by up-regulation of death receptor 5 via endoplasmic reticulum stress - CCAAT/enhancer binding protein homologous protein dependent mechanism 期刊论文 Huawen Li;Guoqiang Chang;Jian Wang;Lihong Wang;Weina Jin;Yani Lin;Yan Yan;Ruojun Wang;Wei Gao;Li Ma;Qinghua Li;Tianxiang Pang
13 CIAPIN1 targets Na+/H+ exchanger 1  to mediate K562 chronic myeloid leukemia cell' differentiation via ERK1/2 signaling pathway 期刊论文 Yongxin Ru|Haoyue Liang|Qinghua Li|Tianxiang Pang|
14  Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen 期刊论文 Pang YK|Dong F|Cheng H|Hao S|Xu J|Zhu XF|Yuan WP|Cheng T|Zheng GG|
15 C/EBPζ targets to neutrophil gelatinase associated lipocalin (NGAL) as a repressor for metastasis of MDA-MB-231 cells 期刊论文 Wang J| Gao W| Lin YN| Jin WN|Chang GQ|Wang RJ|Li QH|Ma L|Pang TX|
16 Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment 期刊论文 ...|Z Cao|Q Li|Z Ju|J Wang|W Yuan|T Cheng|
17 CD44 targets Na+/H+ exchanger 1 to mediate MDA-MB-231 cells metastasis via the regulation of ERK1/2 期刊论文 Guoqiang Chang;Jian Wang;Hongju Zhang;Yujuan Zhang;Chijuan Wang;Hua Xu;Hairui Zhang;Li Ma;Qinghua Li;Tianxiang Pang
18 Na+/H+ exchanger 1 inhibition contributes to K562 leukemic cell differentiation 期刊论文 Jin W| Li Q| Wang J| Chang G| Lin Y| Li H| Wang L|Pang T|
19 Decreased intracellular pH induced by cariporide differentially contributes to human umbilical cord-derived mesenchymal stem cells differentiation 期刊论文 Gao W|Zhang H|Chang G|Xie Z|Wang H|Ma L|Han Z|Li Q|Pang T|
20 The Regulation of Normal and Leukemic Hematopoietic Stem Cells by Niches 期刊论文 Meng-meng Huang| Jiang Zhu |
21 CD44 targets Wnt/beta-catenin pathway to mediate the proliferation of K562 cells 期刊论文 Guoqiang Chang;Hongju Zhang;Jian Wang;Yujuan Zhang;Hua Xu;Chijuan Wang;Hairui Zhang;Li Ma;Qinghua Li;Tianxiang Pang
22 Down-regulation of the P-glycoprotein relevant for multidrug resistance by intracellular acidification through the crosstalk of MAPK signaling pathways 期刊论文 Jin Wei-Na;Lu Ying;Li Qinghua;Wang Jian;Zhang Hongju;Chang Guoqiang;Lin Yani;Pang Tianxiang
23 Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis. 期刊论文 Xu Hua;Wang Jian;Wang Chijuan;Chang Guoqiang;Lin Yani;Zhang Hongju;Zhang Hairui;Li Qinghua;Pang Tianxiang
24 The impact of tumor microenvironments on stem cells. 期刊论文 Wang LN;Cheng T;Zheng GG
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