正常造血干/祖细胞在白血病体内的受抑规律

81090411
2010
H0801.造血、造血调控与造血微环境
程涛
重大项目
教授
中国医学科学院
445万元
造血干/祖细胞;白血病干细胞;造血微环境;数学建模
2011-01至2014-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The p53-PUMA axis suppresses iPSC generation 期刊论文 Miao, W.|Yuan, W.|Yuan, W.|Cheng, S. Y.|Cheng, S. Y.|Gollin, S. M.|Gollin, S. M.|Cheng, T.|Cheng, T.|
2 Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging. 期刊论文 Ju, Zhenyu|Ju, Zhenyu|Zhang, Junling|Zhang, Junling|Gao, Yingdai|Gao, Yingdai|Cheng, Tao|Cheng, Tao|
3 Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen. 期刊论文 Xu, Jing|Zhu, Xiaofan|Zhu, Xiaofan|Yuan, Weiping|Yuan, Weiping|Cheng, Tao|Cheng, Tao|Zheng, Guoguang|Zheng, Guoguang|
4 Antioxidant N-acetyl-l-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice. 期刊论文 Qiu, Lugui|Yuan, Weiping|Yuan, Weiping|Leung, Anskar Yu-Hung|Leung, Anskar Yu-Hung|Yang, Yong-Guang|Yang, Yong-Guang|Cheng, Tao|Cheng, Tao|
5 Stem Cell Science On the Rise in China 期刊论文 程涛|程涛|
6 Stem Cell Science On the Rise in China 期刊论文 Wang, Zack Z.|Deng, Hongkui|Deng, Hongkui|Pei, Duanqing|Pei, Duanqing|Zhou, Qi|Zhou, Qi|Cheng, Tao|Cheng, Tao|
7 Purinergic P2Y(1)(4) receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. 期刊论文 Lee, Dongjun|Park, Baehang|Park, Baehang|Cheng, Tao|Cheng, Tao|Scadden, David T|Scadden, David T|Lee, Byeong Chel|Lee, Byeong Chel|
8 The impact of tumor microenvironments on stem cells 期刊论文 Wang LN|Wang LN|Cheng T|Cheng T|Zheng GG|Zheng GG|
9 An acute negative bystander effect of γ-irradiated recipients on transplanted hematopoietic stem cells 期刊论文 XuFeng, R.|Yuan, Y.|Yuan, Y.|Zhang, P.|Zhang, P.|Smith, C. A.|Smith, C. A.|Cheng, T.|Cheng, T.|
10 Lead Discovery, Chemistry Optimization, and Biological Evaluation Studies of Novel Biamide Derivatives as CB(2) Receptor Inverse Agonists and Osteoclast Inhibitors 期刊论文 程涛|程涛|
11 <strong><span style="line-height: 115%; font-family: ;" roman?,?serif?;font-size:12pt;?="" new="" times="">Myeloid cell-derived reactive oxygen species externally regulate </span><span style=&qu 期刊论文 Haiyan Zhu|Li Chai|Li Chai|Leslie E. Silberstein|Leslie E. Silberstein|Tao Cheng|Tao Cheng|Hongbo R. Luo|Hongbo R. Luo|
12 Distinct sensitivity of CD8+ CD4- and CD8+ CD4+ leukemic cell subpopulations to cyclophosphamide and rapamycin in Notch1-induced T-ALL mouse model 期刊论文 Wang, X.|Gao, Y.|Gao, Y.|Zhu, X.|Zhu, X.|Cheng, T.|Cheng, T.|Yuan, W.|Yuan, W.|
13 The balance of positive and negative effects of TGF-beta signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells 期刊论文 Bai, H.|Xie, Y. L.|Xie, Y. L.|Gao, Y. X.|Gao, Y. X.|Cheng, T.|Cheng, T.|Wang, Z. Z.|Wang, Z. Z.|
14 Suppression of Cytochrome P450 Reductase Enhances Long-Term Hematopoietic Stem Cell Repopulation Efficiency in Mice 期刊论文 Xu, Jing|Ding, Xinxin|Ding, Xinxin|Cheng, Tao|Cheng, Tao|Gu, Jun|Gu, Jun|Yuan, Weiping|Yuan, Weiping|
15 <strong>NKT 细胞与移植物抗宿主病</strong> 期刊论文 赵蕾|赵蕾|郝莎|郝莎|袁卫平|袁卫平|程涛|程涛|
16 <span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;font-size:10.5pt;">p18<sup>INK4C</sup>&nbsp;</span><span style="font-family:&quot;Times New Roman&quot;,&quot; 期刊论文 Ji Qing|Bartlow Patrick|Bartlow Patrick|Ding Yahui|Ding Yahui|Yuan Weiping|Yuan Weiping|Cheng,Tao|Cheng,Tao|
17 Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation. 期刊论文 Gao, Jiao|Wang, Weili|Wang, Weili|Cheng, Tao|Cheng, Tao|Liu, Bing|Liu, Bing|Yang, Xiao|Yang, Xiao|
18 Rictor is required for early B cell development in bone marrow. 期刊论文 Zhang Yingchi;Hu Tianyuan;Hua Chunlan;Gu Jie;Zhang Liyan;Hao Sha;Liang Haoyue;Wang Xiaomin;Wang Weili;Xu Jing;Liu Hanzhi;Liu Bin;Cheng Tao;Yuan Weiping
19 Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). 期刊论文 Xiong, Sidong|Wang, Zhen|Wang, Zhen|Yuan, Jinduo|Yuan, Jinduo|Li, Qiang|Li, Qiang|Zhang, Yan|Zhang, Yan|
20 Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells 期刊论文 Hu, L.|Hou, D.|Hou, D.|Zou, Z.|Zou, Z.|Gao, S.|Gao, S.|Cheng, T.|Cheng, T.|
21 Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment 期刊论文 Tian Chen;Zheng Guoguang;Cao Zhipan;Li Qiao;Ju Zhenyu;Wang Jinhong;Yuan Weiping;Cheng Tao
22 Systematic transcriptome analysis of the zebrafish model of diamond-blackfan anemia induced by RPS24 deficiency 期刊论文 Wan, Yang|Jia, Qiong|Wang, Xiaomin|Zhu, Xiaofan|Leung, Anskar Yu-Hung|Cheng, Tao|Fang, Xiangdong|Yuan, Weiping|Jia, Haibo|
23 p18~(INK4C)调控小鼠T细胞的发育及功能 期刊论文 董芳|王娅婕|王娅婕|程辉|程辉|袁卫平|袁卫平|程涛|程涛|
24 Mouse Embryonic Head as a Site for Hematopoietic Stem Cell Development 期刊论文 袁卫平|袁卫平|
25 Mll2 controls cardiac lineage differentiation of mouse embryonic stem cells by promoting H3K4me3 deposition at cardiac-specific genes. 期刊论文 Zhou, Hong|Li, Qiang|Li, Qiang|Zhang, Shenghai|Zhang, Shenghai|Xiong, Sidong|Xiong, Sidong|Zhang, Yan|Zhang, Yan|
26 Identification of functional cooperative mutations of SETD2 in human acute leukemia 期刊论文 Liu, X.|Yuan, W.|Yuan, W.|Huang, G.|Huang, G.|Cheng, T.|Cheng, T.|Wang, Q. F.|Wang, Q. F.|
27 Reprogramming of MLL-AF9 Leukemic Cells Into Pluripotent Stem Cells in Mice 会议论文 Liu Yanfeng;Cheng Hui;Hu Linping;Xu Jing;Yuan Weiping;Gao Shaorong;Cheng Tao
28 Transcriptome analysis of the zebrafish model of Diamond-Blackfan anemia from RPS19 deficiency via p53-dependent and -independent pathways 期刊论文 Jia Q.;Zhang Q.;Zhang Z.;Wang Y.;Zhang W.;Zhou Y.;Wan Y.;Cheng T.;Zhu X.;Fang X.;Yuan W.;Jia H.
29 An Opposite Effect of the CDK Inhibitor, p18(INK4c) on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells 期刊论文 Li Y.;Pal R.;Sung L. Y.;Feng H.;Miao W.;Cheng S. Y.;Tian C.;Cheng T.
30 Graft-versus-host disease causes broad suppression of hematopoietic primitive cells and blocks megakaryocyte differentiation in a murine model. 期刊论文 Lin Yan;Hu Xiaoxia;Cheng Hui;Pang Yakun;Wang Libing;Zou Lin;Xu Sheng;Zhuang Xiaomeng;Jiang Chuanhe;Yuan Weiping;Cheng Tao;Wang Jianmin
31 Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice 期刊论文 Yao Yunyi;Liu Senyan;Wang Yue;Yuan Weiping;Ding Xinxin;Cheng Tao;Shen Qin;Gu Jun
32 Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment 期刊论文 Tian Chen;Zheng Guoguang;Cao Zhipan;Li Qiao;Ju Zhenyu;Wang Jinhong;Yuan Weiping;Cheng Tao
33 Hematopoietic Stem Cell Regeneration Enhanced by Ectopic Expression of ROS-detoxifying Enzymes in Transplant Mice 期刊论文 Miao Weimin;XuFeng Richard;Park Moo-Rim;Gu Haihui;Hu Linping;Kang Jin Wook;Ma Shihui;Liang Paulina H.;Li Yanxin;Cheng Haizi;Yu Hui;Epperly Michael;Greenberger Joel;Cheng Tao
34 <strong>PI3K/AKT/mTOR信号通路在造血干细胞中作用的研究进展</strong> 期刊论文 张英驰|张英驰|程涛|程涛|袁卫平|袁卫平|
35 <strong>mTOR信号通路在造血及其它系统衰老中作用的研究进展</strong> 期刊论文 华春兰|华春兰|程涛|程涛|袁卫平|袁卫平|
36 <strong>内皮细胞微环境对造血干细胞的调控</strong> 期刊论文 顾欣|顾欣|袁卫平|袁卫平|程涛|程涛|
37 IFN-gamma promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation. 期刊论文 Yang Yanping;Wang Hui;Yu Hui;Yeap Beow Yong;Liang Tingting;Wang Guanjun;Cheng Tao;Yang Yong-Guang
38 Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors. 期刊论文 Yang Peng;Myint Kyaw-Zeyar;Tong Qin;Feng Rentian;Cao Haiping;Almehizia Abdulrahman A;Alqarni Mohammed Hamed;Wang Lirong;Bartlow Patrick;Gao Yingdai;Gertsch Jurg;Teramachi Jumpei;Kurihara Noriyoshi;Roodman Garson David;Cheng Tao;Xie Xiang-Qun
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