AEP切割的tau和APP毒性片段能否在小鼠复制AD样病理和认知损伤
81528007
2015
H0912.神经退行性变及相关疾病
Keqiang Ye
海外及港澳学者合作研究基金
教授
华中科技大学
18万元
阿尔兹海默病；天冬酰胺酰内肽酶；tau蛋白；β淀粉样前体蛋白
2016-01至2017-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Asparagine endopeptidase cleaves alpha-synuclein and mediates pathologic activities in Parkinson's disease. | 期刊论文 | Zhang, Zhentao，Kang, Seong Su，Liu, Xia，Ahn, Eun Hee，Zhang, Zhaohui，He, Li，Iuvone, P Michael，Duong, Duc M，Seyfried, Nicholas T，Benskey, Matthew J，Manfredsson, Fredric P，Jin, Lingjing，Sun, Yi E，Wang, Jian-Zhi，Ye, Keqiang |
| 2 | Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory | 期刊论文 | Yang Y;Wang ZH;Jin S;Gao D;Liu N;Chen SP;Zhang S;Liu Q;Wang X;Liang X;Wei P;Li X;Li Y;Yue C;Li HL;Wang YL;Wang Q;Ke D;Xie Q;Xu F;Wang L;Wang JZ |
| 3 | Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease | 期刊论文 | Wang, Zhi-Hao，Liu, Pai，Liu, Xia，Manfredsson, Fredric P.，Sandoval, Ivette M.，Yu, Shan Ping，Wang, Jian-Zhi，Ye, Keqiang |
| 4 | Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. | 期刊论文 | Zhang, Zhentao，Obianyo, Obiamaka，Dall, Elfriede，Du, Yuhong，Fu, Haian，Liu, Xia，Kang, Seong Su，Song, Mingke，Yu, Shan-Ping，Cabrele, Chiara，Schubert, Mario，Li, Xiaoguang，Wang, Jian-Zhi，Brandstetter, Hans，Ye, Keqiang |
| 5 | Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling | 期刊论文 | Yaling Yin;Di Gao;Yali Wang;Zhi-Hao Wang;Xin Wang;Jinwang Ye;Dongqin Wu;Lin Fang;Guilin Pi;Ying Yang;Xiao-Chuan Wang;Chengbiao Lu;Keqiang Ye;Jian-Zhi Wang |
查看更多信息请先登录或注册
