尿素通道蛋白作为新型利尿药作用靶标的确认及其活性化合物的结构优化

81330074
2013
H34.药物学
杨宝学
重点项目
教授
北京大学
290万元
利尿药;先导化合物;药物化学;尿素通道;新药物靶标
2014-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Generation and phenotypic analysis of mice lacking all urea transporters 期刊论文 Jiang T;Li Y;Layton AT;Wang W;Sun Y;Li M;Zhou H;Yang B
2 Aquaporins in Urinary System 期刊论文 Li Y;Wang W;Jiang T;Yang B
3 Extrarenal Phenotypes of the UT-B Knockout Mouse 期刊论文 Yang B.;X Li;L. Guo;Y. Meng;Z. Dong;X. Zhao
4 Transport characteristics of urea transporter-B 期刊论文 Yang B.
5 Water Transport Mediated by Other Membrane Proteins 期刊论文 Boyue Huang;Hongkai Wang;Baoxue Yang
6 Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress 期刊论文 Zhong D.;H. Wang;M. Liu;X. Li;M. Huang;H. Zhou;S. Lin;Z. Lin;B. Yang
7 凝血酶激活的纤溶抑制物在心脑血管疾病中作用的研究进展 期刊论文 李英杰;杨宝学
8 Urea transporter knockout mice and their renal phenotypes 期刊论文 Fenton R. A.;B. Yang
9 Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway 期刊论文 Liu Jiangfeng;Wang Weiling;Liu Ming;Su Limin;Zhou Hong;Xia Yin;Ran Jianhua;Lin Herbert Y.;Yang Baoxue
10 Dapagliflozin Aggravates Renal Injury via Promoting Gluconeogenesis in db/db Mice 期刊论文 Yingli Jia;Jinzhao He;Liang Wang;Limin Su;Hong Zhou;Baoxue Yang
11 Ganoderma triterpenes retard renal cyst development via down-regulating Ras/MAPK signaling pathway and promoting cell differentiation 期刊论文 Su L;Liu L;Jia Y;Lei L;Liu J;Zhu S;Zhou H;Chen R;Lu HAJ;Yang B
12 尿素通道蛋白抑制剂的应用 专利 杨宝学;李飞;周虹;雷天落;李敏
13 Elevated urinary urea by high-protein diet could be one of the inducements of bladder disorders 期刊论文 Liu M.;M. Li;J. Liu;H. Wang;D. Zhong;H. Zhou;B. Yang
14 Transport Characteristics of Aquaporins 期刊论文 Geng X;B. Yang
15 NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip 期刊论文 Ren H;B. Yang;P.A. Molina;J.M. Sands;J.D. Klein
16 Development and validation of an LC-MS/MS method for the determination of a novel thienoquinolin urea transporter inhibitor PU-48 in rat plasma and its application to a pharmacokinetic study 期刊论文 Zhang Z;Yang BX;Wang X;Liu D;ZHang H;Zhang Q;Lu Y;Li P;Lou Y;Yang B;Lu C;Lou Y;Zhang G
17 Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload 期刊论文 Jia Yingli;Sun Yi;Weng Lin;Li Yingjie;Zhang Quanbin;Zhou Hong;Yang Baoxue
18 Urea Transporters 专著 Baoxue Yang;Jeff Sands
19 Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway 期刊论文 Yi Sun;Chi-Wai Lau;Yingli Jia;Yingjie L;WeilingWang;Jianhua Ran;Fei Li;Yu Huang;Hong Zhou;BaoxueYang
20 尿素通道蛋白B的转运活性 期刊论文 钟丹丹;杨宝学
21 Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling 期刊论文 Wang W;F. Li;Y. Sun;L. Lei;H. Zhou;T. Lei;Y. Xia;A. S. Verkman;B. Yang
22 Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters 期刊论文 Ren H.;Y. Wang;Y. Xing;J. Ran;M. Liu;T. Lei;H. Zhou;R. Li;J.M. Sands;B. Yang
23 尿素通道蛋白的组织分布和生理功能 期刊论文 姜涛;杨宝学
24 Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF 期刊论文 Dandan Zhong;Zhengwei Xie;Boyue Huang;Shuai Zhu;Guoqian Wang;Hong Zhou;Shuqian Lin;Zhibin Lin;Baoxue Yang
25 Aquaporins in Digestive System 期刊论文 Zhu S;J. Ran;B. Yang;Z. Mei.
26 Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury 期刊论文 Lei L;Wang W;Jia Y;Su L;Zhou H;Verkman AS;Yang B
27 Developing hypothetical inhibition mechanism of novel urea transporter B inhibitor 期刊论文 Li M.;W.I. Tou;H. Zhou;F. Li;H. Ren;C.Y. Chen;B. Yang
28 1-[2-(3-氨基-6-甲基噻吩并2,3-b喹啉基)]乙酮在制备血管扩张剂中的应用 专利 周虹;杨宝学;孙逸
29 The knockout of urea transporter-B improves the hemorheological properties of erythrocyte 期刊论文 Geng Xiaoqianga;Lei Tianluoa;Hong Zhou;Weijuan Yao;Xin Weihongc;Baoxue Yang
30 Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes 期刊论文 Chen J.;W. Wang;Q. Zhang;F. Li;T. Lei;D. Luo;H. Zhou;B. Yang
31 一种尿素通道蛋白抑制剂优必的应用 专利 杨宝学;李飞;周虹;雷天落;李敏
32 一种尿素通道蛋白抑制剂优体的应用 专利 杨宝学;李飞;周虹;雷天落;李敏
33 Aquaporins in Nervous System 期刊论文 Xu M;M. Xiao;S. Li;B. Yang
34 3-氨基-6-甲氧基噻吩并[2,3-b]喹啉-2-羧酸甲酯的合成工艺研究 期刊论文 邢永宁;苏奥泽;杨宝学;李润涛
35 Aquaporins 专著 Baoxue Yang
36 Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model 期刊论文 Ran Jian-hua;Li Min;Tou Weng-Ieong;Lei Tian-luo;Zhou Hong;Chen Calvin Yu-Chian;Yang Bao-xue
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