基于分子靶向给药的肿瘤联合治疗

81130059
2011
H3408.药剂学
张强
重点项目
教授
北京大学
280万元
肿瘤;化疗药;作用机理;联合治疗;分子动靶向给药
2012-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Combined mTOR inhibitor rapamycin and doxorubicin-loaded cyclic octapeptide modified liposomes for targeting integrin alpha 3 in triple-negative breast cancer 期刊论文 He, Qihua|Wang, Xueqing|Zhang, Hua|Zhang, Qiang|
2 Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis 期刊论文 Zhang, Hua|Wang, Xueqing|Fang, Weigang|Zhang, Qiang|
3 Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis 期刊论文 Dai, Wenbing|Gemeinhart, Richard A.|Zhang, Qiang|Li, Tonglei|
4 A specific peptide ligand-modified lipid nanoparticle carrier for the inhibition of tumor metastasis growth 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
5 Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)-Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo 期刊论文 Dai, Wenbing|He, Bing|Wang, Xueqing|Zhang, Qiang|
6 Transferrin receptor specific nanocarriers conjugated with functional 7peptide for oral drug delivery 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
7 A smart tumor targeting peptide-drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells 期刊论文 Zhang, Hua|Dai, Wenbing|Wang, Xueqing|Zhang, Qiang|
8 Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo 期刊论文 Dai, Wenbing|Wang, Xinglin|Wang, Xueqing|Zhang, Qiang|
9 The impact of a chlorotoxin-modified liposome system on receptor MMP-2 and the receptor-associated protein ClC-3 期刊论文 Zhang, Xuan|Wang, Guangji|Yin, Lifang|Zhang, Qiang|
10 Nanotoxicity comparison of four amphiphilic polymeric micelles with similar hydrophilic or hydrophobic structure 期刊论文 Wang, Jun|Zhong, Zhen-Lin|Wu, Hou-Nan|Zhang, Qiang|
11 The use of alpha-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to alpha 7 nAChR-overexpressing breast cancer 期刊论文 Zhang, Xuan|Lu, Wanliang|Zhou, Demin|Zhang, Qiang|
12 Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis 期刊论文 Dai, Wenbing|Wang, Xinglin|Wang, Xueqing|Zhang, Qiang|
13 Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
14 Dual targeting for metastatic breast cancer and tumor neovasculature by EphA2-mediated nanocarriers 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
15 The modulation of tumor vessel permeability by thalidomide and its impacts on different types of targeted drug delivery systems in a sarcoma mouse model 期刊论文 Zhang, Hua|Wang, Xueqing|Tian, Jie|Zhang, Qiang|
16 Novel Biological Functions of ZIF-NP as a Delivery Vehicle: High Pulmonary Accumulation, Favorable Biocompatibility, and Improved Therapeutic Outcome 期刊论文 Zhong, Chongli|Wu, Hounan|Yang, Qingyuan|Zhang, Qiang|
17 A comparative study of thermo-sensitive hydrogels with water-insoluble paclitaxel in molecule, nanocrystal and microcrystal dispersions 期刊论文 Wang, Xueqing|Dai, Wenbing|Yin, Yuxin|Zhang, Qiang|
18 他莫昔芬介导脂质体细胞内化的机制研究(英文) 期刊论文 王学清|王坚成|张烜|张强|
19 A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel 期刊论文 Wang, Jiancheng|Zhang, Xuan|Zhang, Hua|Zhang, Qiang|
20 The transport pathways of polymer nanoparticles in MDCK epithelial cells 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
21 Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer 期刊论文 Dai, Wenbing|Zhang, Hua|Wang, Xueqing|Zhang, Qiang|
22 The development of site-specific drug delivery nanocarriers based on receptor mediation 期刊论文 Zhang, Hua|Dai, Wenbing|He, Bing|Zhang, Qiang|
23 Targeting efficiency of RGD-modified nanocarriers with different ligand intervals in response to integrin alpha v beta 3 clustering 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
24 The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cells 期刊论文 Wang, Jun|Wang, Xing-Lin|Wang, Xue-Qing|Zhang, Qiang|
25 The reduction of tumor interstitial fluid pressure by liposomal imatinib and its effect on combination therapy with liposomal doxorubicin 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
26 Bionano Interactions of MCF-7 Breast Tumor Cells with a Transferrin Receptor Targeted Nanoparticle 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
27 Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes 期刊论文 Zhang, Xuan|Wang, Guangji|Yin, Lifang|Zhang, Qiang|
28 The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhan, Qiang|
29 维生素A修饰的阿霉素隐形脂质体对肝星状细胞的靶向性 期刊论文 章俊麟|金武|王学清|张强|
30 Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
31 A novel approach to improve the pharmacokinetic properties of 8-chloro-adenosine by the dual combination of lipophilic derivatisation and liposome formulation 期刊论文 Wang, Xue-qing|Lu, Wan-liang|Yang, Zhen-jun|Zhang, Qiang|
32 The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells 期刊论文 Wang, Xueqing|Wang, Jiancheng|Zhang, Xuan|Zhang, Qiang|
33 iRGD修饰的阿霉素主动靶向脂质体的细胞毒与抗肿瘤效果评价 期刊论文 王学清|代文兵|张强|王杏林|
34 Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis 期刊论文 Dai, Wenbing|Gemeinhart, Richard A.|Zhang, Qiang|Li, Tonglei|
35 Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis 期刊论文 Dai, Wenbing|Wang, Xinglin|Wang, Xueqing|Zhang, Qiang|
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