代谢性炎症发生的机制及其在糖代谢稳态失衡中的作用
81390354
2013
H07.内分泌系统/代谢和营养支持
阮雄中
重大项目
教授
重庆医科大学
320万元
慢性炎症;肥胖症;糖代谢异常;胰岛素抵抗;
2014-01至2018-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | TSC1-mTOR signaling determines brown-to-white adipocyte phenotypic switch | 期刊论文 | Xiang, Xinxin; Lan, He; Tang, Hong; Yuan, Fang; Xu, Yanhui; Zhao, Jing; Li, Yin; Zhang, Weizhen |
| 2 | R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating beta-catenin. | 期刊论文 | Liu Shiying; Yin Yue; Yu Ruili; Li Yin; Zhang Weizhen |
| 3 | Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery. | 期刊论文 | He Rui; Yin Yue; Yin Wenzhen; Li Yin; Zhao Jing; Zhang Weizhen |
| 4 | mTOR activation protects liver from ischemia/reperfusion-induced injury through NF-kappaB pathway | 期刊论文 | Li, Ziru; Zhang, Jing; Mulholland, Michael; Zhang, Weizhen |
| 5 | Lipopolysaccharide inhibits the expression of resistin in adipocytes | 期刊论文 | Xiang Xinxin();An Wenjiao;Jiang Changtao;Zhao Jing;Wang Xian;Sun Guang;Li Yin();Zhang Weizhen() |
| 6 | Irisin inhibits hepatic cholesterol synthesis via AMPK/SREBP2 signaling | 期刊论文 | Tang, Hong; Yu, Ruili; Liu, Shiying; Huwatibieke, Bahetiyaer; Li, Ziru; Zhang, Weizhen |
| 7 | Genome-Wide Transcriptome Analysis of CD36 Overexpression in HepG2.2.15 Cells to Explore Its Regulatory Role in Metabolism and the Hepatitis B Virus Life Cycle | 期刊论文 | Huang Jian;Zhao Lei;Yang Ping;Chen Zhen;Tang Ni;Ruan Xiong Z.;Chen Yaxi |
| 8 | Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice | 期刊论文 | Zhao Lei;Zhong Shan;Qu Haiyang;Xie Yunxia;Cao Zhennan;Li Qing;Yang Ping;Varghese Zac;Moorhead John F;Chen Yaxi;Ruan Xiong Z |
| 9 | Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice. | 期刊论文 | Yang Ping; Xiao Yayun; Luo Xuan; Zhao Yunfei; Zhao Lei; Wang Yan; Wu Tingting; Wei Li; Zac Varghese; John F Moorhead; Chen Yaxi; Xiong Z Ruan |
| 10 | Suppression of CD36 attenuates adipogenesis with a reduction of P2X7 expression in 3T3-L1 cells | 期刊论文 | Gao Huanqing;Li Danyang;Yang Ping;Zhao Lei;Wei Li;Chen Yaxi();Ruan Xiong Z.() |
| 11 | HDAC5-mTORC1 interaction in differential regulation of ghrelin and nucleobindin2 (NUCB2)/nesfatin-1 | 期刊论文 | Ma, Liangxiao; Tang, Hong; Yin, Yue; Yu, Ruili; Zhao, Jing; Li, Yin; Mulholland, Michael W.; Zhang, Weizhen |
| 12 | LGR4 and its role in intestinal protection and energy metabolism | 期刊论文 | Li, Ziru; Zhang, Weizhen; Mulholland, Michael W. |
| 13 | Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and Hepatic Inflammation by Upregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway | 期刊论文 | Zhong Shan();Zhao Lei();Wang Yan;Zhang Chang;Liu Jun;Wang Pei;Zhou Wei;Yang Ping;Varghese Zac;Moorhead John F.;Chen Yaxi();Ruan Xiong Z.() |
| 14 | mTOR Signaling in X/A-Like Cells Contributes to Lipid Homeostasis in Mice. | 期刊论文 | Li Ziru; Yu Ruili; Yin Wenzhen; Qin Yan; Ma Liangxiao; Mulholland Michael; Zhang Weizhen |
| 15 | Exendin-4 decreases ghrelin levels through mTOR signaling | 期刊论文 | Hong Xiaosi;Zhang Heng;Liang Hongbin;Li Danjie;Huang Jiana;Li Zhi;Jiang Sibo;Zhang Weizhen;Xu Geyang |
| 16 | The Role of Ghrelin in Senescence: A Mini-Review | 期刊论文 | Yin Yue;Zhang Weizhen |
| 17 | Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway | 期刊论文 | Moorhead, John F.|Varghese, Zac|Chen, Yaxi|Ruan, Xiong Z.| |
| 18 | Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis | 期刊论文 | Moorhead JF|Varghese Z|Chen Y|Ruan XZ| |
| 19 | Inflammatory Stress Induces Statin Resistance by Disrupting 3-Hydroxy-3-Methylglutaryl-CoA Reductase Feedback Regulation | 期刊论文 | Chen Yaxi;Ku Halcyon;Zhao Lei;Wheeler David C.;Li Lung-Chih;Li Qing;Varghese Zac;Moorhead John F.;Powis Stephen H.;Huang Ailong;Ruan Xiong Z. |
| 20 | Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo | 期刊论文 | Yang Ping;Zhao Yunfei;Zhao Lei;Yuan Jun;Chen Yao;Varghese Zac;Moorhead John F;Chen Yaxi;Ruan Xiong Z |
| 21 | Ghrelin O-acyltransferase (GOAT) and energy metabolism | 期刊论文 | Li, Ziru; Mulholland, Michael; Zhang, Weizhen |
| 22 | Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway. | 期刊论文 | Yang Ping();Su Chunxiao();Luo Xuan();Zeng Han;Zhao Lei;Wei Li;Zhang Xiaoyu;Varghese Zac;Moorhead John F;Chen Yaxi();Ruan Xiong Z() |
| 23 | Esophagus-duodenum Gastric Bypass Surgery Improves Glucose and Lipid Metabolism in Mice. | 期刊论文 | He Rui; Yin Yue; Li Yin; Li Ziru; Zhao Jing; Zhang Weizhen |
| 24 | Fatty acid translocase promoted hepatitis B virus replication by upregulating the levels of hepatic cytosolic calcium | 期刊论文 | Huang Jian();Zhao Lei;Yang Ping;Chen Zhen;Ruan Xiong Z;Huang Ailong;Tang Ni();Chen Yaxi() |
| 25 | Knocking down Stard3 decreases adipogenesis with decreased mitochondrial ROS in 3T3-L1 cells. | 期刊论文 | Zhou Xiaoqian;Gao Huanqing;Guo Yinfeng;Chen Yaxi();Ruan Xiong Z() |
| 26 | Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation | 期刊论文 | Varghese Z|Moorhead JF|Powis SH|Ruan XZ| |
| 27 | TSC1-mTOR signaling determines the differentiation of islet cells | 期刊论文 | Li Ding;Yue Yin;Lingling Han;Yin Li;Jing Zhao;Weizhen Zhang |
| 28 | Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion | 期刊论文 | Qin, Yan|Li, Ziru|Wang, Zhigang|Li, Yin|Zhao, Jing|Mulholland, Michael|Zhang, Weizhen| |
| 29 | Nesfatin-1 promotes brown adipocyte phenotype | 期刊论文 | Wang Yuexin();Li Ziru;Zhang Xinyu;Xiang Xinxin;Li Yin;Mulholland Michael W.();Zhang Weizhen() |
| 30 | Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPAR gamma signaling pathway | 期刊论文 | Li Ziru;Xu Geyang;Qin Yan;Zhang Chao;Tang Hong;Yin Yue;Xiang Xinxin;Li Yin;Zhao Jing;Mulholland Michael;Zhang Weizhen |
| 31 | The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation | 期刊论文 | Yin, Yue|Li, Yin|Zhang, Weizhen| |
| 32 | Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet | 期刊论文 | Wu, Yu; Wu, Tingting; Wu, Jun; Zhao, Lei; Li, Qing; Varghese, Zac; Moorhead, John F.; Powis, Stephen H.; Chen, YX; Ruan, Xiong Z. |
| 33 | AMPK-dependent regulation of GLP1 expression in L-like cells | 期刊论文 | Sushi Jiang;Hening Zhai;Danjie Li;Jiana Huang;Ziru Li;Weizhen Zhang();Geyang Xu() |
| 34 | SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE-/- mice | 期刊论文 | Li, Danyang; Chen, Amei; Lan,Tan; Zou,Yang; Zhao,Lei; Yang,Ping; Qu,Haiyang; Wei,Li; Varghese, Z; Moorhead, JF; Chen,Yaxi; Ruan,Xiong Z |
| 35 | CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis. | 期刊论文 | Zhao, Lei; Zhang, Chang; Luo, Xiaoxiao; Wang, Pei; Zhou, Wei; Zhong, Shan; Xie, Yunxia; Jiang, Yibo; Yang, Ping; Tang, Renkuang; Pan, Qin; Hall, Andrew R; Luong, Tu Vinh; Fan, Jiangao; Varghese, Zac; Moorhead, John F; Pinzani, Massimo; Chen, Yaxi; Ruan, Xiong Z |
| 36 | CD36 and lipid metabolism in the evolution of atherosclerosis | 期刊论文 | Zhao Lei;Varghese Z;Moorhead J F;Chen Yaxi;Ruan Xiong Z() |
| 37 | Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice. | 期刊论文 | Wu Wei;Zhao Lei;Yang Ping;Zhou Wei;Li Beibei;Moorhead John F;Varghese Zac;Ruan Xiong Z();Chen Yaxi() |
| 38 | Ghrelin Inhibits the Differentiation of T Helper 17 Cells through mTOR/STAT3 Signaling Pathway | 期刊论文 | Yanhui Xu;Ziru Li;Yue Yin;He Lan;Jun Wang;Jing Zhao;Juan Feng;Yin Li;Weizhen Zhang |
| 39 | Long-chain fatty acid activates hepatocytes through CD36 mediated oxidative stress | 期刊论文 | Liu Jun();Yang Ping();Zuo Guoqing();He Song;Tan Wei;Zhang Xiaoyu;Su Chunxiao;Zhao Lei;Wei Li;Chen Yao;Ruan Xiongzhong;Chen Yaxi() |
| 40 | AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1 | 期刊论文 | Yin Yue;Li Ziru;Gao Ling;Li Yin;Zhao Jing;Zhang Weizhen |
| 41 | Central and peripheral irisin differentially regulate blood pressure | 期刊论文 | Zhang Weizhen;Chang Ling;Zhang Chao;Zhang Ruthann Li Ziru Chai Biaoxin Li Jiyao Chen Eugene;Mulholland Michael |
| 42 | Irisin: A myokine with locomotor activity | 期刊论文 | Zhang Weizhen;Chang Lin;Zhang Chao;Zhang Ruthann;Li Ziru;Chai Biaoxin;Li Jiyao;Chen Eugene;Mulholland Michael |
| 43 | CD36 in chronic kidney disease: novel insights and therapeutic opportunities | 期刊论文 | Yang Xiaochun;Okamura Daryl M.;Lu Xifeng;Chen Yaxi;Moorhead John;Varghese Zac;Ruan Xiong Z. |
| 44 | Neurogenin 3 directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma | 期刊论文 | Ding, Li; Han, Lingling; Li, Yin; Zhao, Jing; He, Ping; Zhang, Weizhen |
| 45 | Can irisin be a linker between physical activity and brain function? | 期刊论文 | Zhang Jing; Zhang weizhen |
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