乙型肝炎病毒逃逸免疫反应的分子结构基础研究
31390432
2013
C0801.固有免疫
高福
重大项目
研究员
中国科学院微生物研究所
400万元
乙型肝炎病毒（HBV）;抗原递呈T细胞免疫;免疫抑制受体与配体相互作用;免疫逃逸;结构基础
2014-01至2018-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | CD8(+) T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress | 期刊论文 | Zhang Yu; Wu Yan; Deng Mengmeng; Xu Dongping; Li Xiaodong; Xu Zhihui; Hu Jun; Zhang Han; Liu Kefang; Zhao Yingze; Gao Feng; Bi Shengli; Gao George F.; Zhao Jingmin; Liu William J.; Meng Songdong |
| 2 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy | 期刊论文 | Liu Kefang();Tan Shuguang();Chai Yan;Chen Danqing;Song Hao;Zhang Catherine Wei-Hong;Shi Yi;Liu Jun;Tan Wenjie;Lyu Jianxin;Gao Shan;Yan Jinghua;Qi Jianxun();Gao George F() |
| 3 | Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors. | 期刊论文 | Lin Xia;Yu Liu;Zhibo Li |
| 4 | PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid | 期刊论文 | Lu Qiong;Lu Guangwen;Qi Jianxun;Wang Han;Xuan Yifang;Wang Qihui;Li Yan;Zhang Yanfang;Zheng Chunfu;Fan Zheng;Yan Jinghua;Gao George F. |
| 5 | Seeing is believing: anti-PD-1/PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy. | 期刊论文 | Tan Shuguang();Zhang Catherine W-H;Gao George F() |
| 6 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies | 期刊论文 | Tan Shuguang();Chen Danqing;Liu Kefang;He Mengnan;Song Hao;Shi Yi;Liu Jun;Zhang Catherine W. -H.;Qi Jianxun;Yan Jinghua;Gao Shan();Gao George F.() |
| 7 | 一种抗PD-1抗体及其应用 | 专利 | 高福;严景华;谭曙光;仝舟;陈丹青;张浩;何为无;马东辉 |
| 8 | Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab | 期刊论文 | Tan Shuguang();Liu Kefang();Chai Yan;Zhang Catherine W.-H.;Gao Shan;Gao George F;Qi Jianxun() |
| 9 | 一种结核诊断组合物及其应用 | 专利 | 高福;谭曙光;范盘生;张宁;万康林 |
| 10 | 生命科学研究 | 奖励 | 高福 |
| 11 | 个人奖 | 奖励 | 邹建平;熊贞晟;秦元成 |
| 12 | 个人奖 | 奖励 | 邹建平;熊贞晟;秦元成 |
| 13 | Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies | 期刊论文 | He Mengnan();Chai Yan();Qi Jianxun;Zhang Catherine W H;Tong Zhou;Shi Yi;Yan Jinghua;Tan Shuguang();Gao George F() |
| 14 | 生命科学领域 | 奖励 | 高福 |
| 15 | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab | 期刊论文 | Li Yan; Tan Shuguang; Zhang Chang; Chai Yan; He Mengnan; Zhang Catherine W-H; Wang Qihui; Tong Zhou; Liu Kefang; Lei Yifan; Liu William J.; Liu Yingxia; Tian Zhigang; Cao Xuetao; Yan Jinghua; Qi Jianxun; Tien Po; Gao Shan; Gao George F. |
| 16 | Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5. | 期刊论文 | Wang Han; Qi Jianxun; Zhang Shuijun; Li Yan; Tan Shuguang; Gao George F |
| 17 | An unexpected N-terminal loop in PD-1 dominates binding by nivolumab | 期刊论文 | Tan Shuguang();Zhang Hao();Chai Yan();Song Hao;Tong Zhou;Wang Qihui;Qi Jianxun;Wong Gary;Zhu Xiaodong;Liu William J;Gao Shan;Wang Zhongfu;Shi Yi;Yang Fuquan;Gao George F();Yan Jinghua() |
| 18 | CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection. | 期刊论文 | Tan Shuguang();Lin Nan;Huang Mingxiang;Wang Qing;Tan Yunhong;Li Bingxi;Zhang Ning;Guo Tianling;Cui Yingbin;Chen Xinchao;Wang Dongping;Wang Jue;Xiao Haixia;Liu William J;Yan Jinghua;Zhang Catherine W-H;Liu Cui Hua;Wan Kanglin();Gao George F() |
| 19 | T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV | 期刊论文 | William J. Liu;Min Zhao;Kefang Liu;Kun Xu;Gary Wong;Wenjie Tan;George F. Gao |
| 20 | Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I | 期刊论文 | Xiao, Jin; Xiang, Wangzhen; Chai, Yan; Haywood, Joel; Qi, Jianxun; Ba, Limin; Qi, Peng; Wang, Ming; Liu, Jun; Gao, George F |
| 21 | 精准医疗与肿瘤免疫治疗伴随诊断 | 期刊论文 | 谭曙光()();高福 |
| 22 | 可用于结核分枝杆菌感染检测的表位多肽及其应用 | 专利 | 高福;谭曙光 |
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