新一代非核苷类HIV-RT抑制剂先导物的结构优化和类药性研究

30930106
2009
H3401.合成药物化学
谢蓝
重点项目
研究员
中国人民解放军军事科学院军事医学研究院
190万元
非核苷类HIV逆转录酶抑制剂;抗耐药性;药物代谢动力学;先导物优化;类药性
2010-01-01到2013-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Synthesis and biological evaluation of dibenzocyclooactatetraenederivatives and relatedunsymmetrical biphenyls as new antitumor agents inhibiting NF-κB signaling pathway 期刊论文 F. L.Yu, X. Y. He, C. Gu,E. Ohkoshi,L. T. Wang,|
2 Discovery of diarylamines and diarylethers as selective Mer kinase tyrosine kinase inhibitors 会议论文 L Xie|X. T. Tian|E. Ohkoshi|B. Qin|Y. N. Liu|H. Y. Hung|P. C. Wu|R. Huang|J. H. Hsieh|
3 二芳基嘧啶类HIV-1非核苷类逆转录酶抑制剂研究进展 期刊论文 田兴涛|谢蓝|
4 Synthesis, anti-HIV activity and drug–like property evaluation of diarylanilines and diarylpyridinamines as novel HIV-1 NNRTIs. 会议论文 L. Xie|L. Q. Sun|Z. Y. Wu|B. Qin|L. Huang|K. Qian|C. H. Chen|K. H. Lee|
5 抗HIV候选化合物DAPA-7035的大鼠药代动力学研究 期刊论文 王瑞|原梅|王生彪|谢剑炜|李桦|谢蓝|
6 Discovery of N-aryl-6-methoxy-1,2,3,4-tetrahydro-quinolines as anovel class of antitumor agents targeting at colchicine binding site of tubulin 期刊论文 X. F. Wang, S.B. Wang, E. Ohkoshi, L. T. Wang,E.|
7 Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors, 期刊论文 L Xie|X. K. Jiang,,|H. Lu|X. T. Tian|F. Barbault|C. H. Chen|S. Jiang|R. Huang|K. Qian|
8 Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors 期刊论文 X. T. Tian|B. J. Qin,|Z. Y. Wu|H. Lu|X. F. Wang| S. Jiang|C. H. Chen|K. H. Lee|L Xie|
9 新型非核苷类HIV-1逆转录酶抑制剂研究进展 期刊论文 谢蓝|田兴涛|
10 二芳基胺类抗肿瘤先导物的结构修饰和活性评价 期刊论文 王生彪|王晓锋, 谢蓝,|
11 Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site 期刊论文 X. F. Wang, F. Guan, E. Ohkoshi, W. Guo, L. Wang,|
12 A New 3D-Pharmacophore Model Based on Tubulin-Colchicine Binding Site and Ligands for Virtual Screening of New Leads 会议论文 X. F. Wang|B. J. Qin|L. Xie|
13 Discovery and optimization of antitumor diaryl-tertiaryamines as novel tubulin inhibitors targeting colchicines binding site （邀请报告） 会议论文 谢蓝|
14 Pharmacophore Mapping and Virtual Screening Based on the Cochicine Binding Site for Hit Identification 会议论文 X. F. Wang,|B. J. Qin,|L Xie|
15 Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents, 期刊论文 谢蓝|X. T. Tian|E. Ohkoshi|B. J. Qin|Y. N. Liu|P. C. Wu|H. Y. Hung|M. J. Hour|K. Qian|
16 Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors 期刊论文 L.Q. Sun| B. Qin|L. Huang| K. Qian|C. H. Chen|K. H. Lee|L Xie|
17 新一代HIV–NNRTIs二芳基苯胺类先导物的结构优化和类药性评价 会议论文 刘娜|谢蓝|
18 分子模拟技术在抗HIV新药研究中的应用 会议论文 谢蓝|
19 Design and discovery of diarylpyridines and diarylanilines as novel potent non-nucleoside hiv-1 reverse transcriptase inhibitors 会议论文 秦炳杰|田兴涛|蒋兴凯|武智渊|王晓锋|谢蓝|
20 基于微管蛋白和秋水仙碱结合位点化合物构建3D-药效团新模型及先导物虚拟筛选 期刊论文 王晓锋|秦炳杰|谢蓝|
21 Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 NNRTI drug candidates 期刊论文 L.Q. Sun,|L. Zhu|K. Qian| B. Qin| L Huang|C. H. Chen|K. H. Lee|L. Xie|
22 两类抗HIV先导物的大鼠肝微粒体的代谢产物筛查 期刊论文 王瑞|陈佳|秦炳杰|谢剑伟|李桦|谢蓝|
23 Synthesis and Biological Evaluation of N-Alkyl-N-(4-methoxyphenyl)pyridin-2-amines asa New Class of Tubulin Polymerization Inhibitors 期刊论文 X. F. Wang, E. Ohkoshi, S. B. Wang, E. Hamel, K.|
24 Diarylaniline derivatives as a novel class of HIV-1 non-nucleoside reverse transcriptase inhibitors 会议论文 K. H. Lee|B. Qin,|X. T. Tian|X. K. Jiang|H. Lu|F. Barbault|L. Huang|K. Qian|R. Huang|
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