线粒体自噬关键蛋白Parkin的动态修饰与化学小分子干预
91853109
2018
B0702.生物分子的化学生物学
孙洋
重大研究计划
教授
南京大学
60万元
线粒体自噬;先导化合物;化学小分子;磷酸化修饰;动态修饰
2019-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Enhanced Copper-Temozolomide Interactions by Protein for Chemotherapy against Glioblastoma Multiforme. | 期刊论文 | Xiao Li;Fenli Shao;Jian Sun;Ke Du;Yang Sun;Fude Feng |
| 2 | 新型冠状病毒肺炎的免疫失衡及干预策略 | 期刊论文 | 杨晨茜;瞿娇;刘怡彤;孟思伟;王冰琳;冯美卿;孙洋 |
| 3 | Sonidegib在制备治疗强直性脊柱炎药物中的应用 | 专利 | 孙洋;徐强;邵粉丽 |
| 4 | 炎症及相关疾病治疗的新靶点和新策略研究 | 奖励 | 徐强;郭文洁;孙洋;吴雪丰;吴兴新;罗琼;沈燕;刘雯 |
| 5 | Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. | 期刊论文 | Jian Gao;Shuang Peng;Xinni Shan;Guoliang Deng;Lihong Shen;Jian Sun;Chunhong Jiang;Xiaoling Yang;Zhigang Chang;Xinchen Sun;Fude Feng;Lingdong Kong;Yanhong Gu;Wenjie Guo;Qiang Xu;Yang Sun |
| 6 | 蛋白酪氨酸磷酸酶SHP2抑制剂在制备治疗银屑病药物中的应用(授权专利) | 专利 | 孙洋;徐强;朱雨雨;郭文洁 |
| 7 | Deciphering the rules of in silico autophagy methods for expediting medicinal research | 期刊论文 | Yi Chen;Guan Wang;Haoyang Cai;Yang Sun;Liang Ouyang;Bo Liu |
| 8 | 阿司匹林在制备治疗子宫内膜增生药物中的应用 | 专利 | 孙洋;徐强;瞿娇;张涛;丁衍 |
| 9 | Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis | 期刊论文 | Fenli Shao;Qianqian Liu;Yuyu Zhu;Zhidan Fan;Wenjun Chen;Shijia Liu;Xiaohui Li;Wenjie Guo;Gen-Sheng Feng;Haiguo Yu;Qiang Xu;Yang Sun |
| 10 | Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophagesmediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice | 期刊论文 | Yuyu Zhu;Ning Wan;Xinni Shan;Guoliang Deng;Qiang Xu;Hui Ye;Yang Sun |
| 11 | Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels | 期刊论文 | Wen Liu;Ye Yin;Meijing Wang;Ting Fan;Yuyu Zhu;Lihong Shen;Shuang Peng;Jian Gao;Guoliang Deng;Xiangbao Meng;Lingdong Kong;Gensheng Feng;Wenjie Guo;Qiang Xu;Yang Sun |
| 12 | Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis | 期刊论文 | Yuyu Zhu;Zhigui Wu;Wei Yan;Fenli Shao;Bowen Ke;Xian Jiang;Xianjia Qi;Wenjie Guo;Yuping Lai;Dijun Chen;Qiang Xu;Yang Sun |
| 13 | 蛋白酪氨酸磷酸酶SHP2抑制剂在制备治疗骨关节炎药物中的应用 | 专利 | 孙洋;徐强;刘倩倩;王美晶 |
| 14 | Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis | 期刊论文 | Mingxia Zhao;Lihong Shen;Zijun Ouyang;Manru Li;Guoliang Deng;Chenxi Yang;Wei Zheng;Lingdong Kong;Xuefeng Wu;Xudong Wu;Wenjie Guo;Ye Yin;Qiang Xu;Yang Sun |
| 15 | Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics | 期刊论文 | Jian Gao;Zhigui Wu;Mingxia Zhao;Rui Zhang;Manru Li;Dongdong Sun;Haibo Cheng;Xianjia Qi;Yuxian Shen;Qiang Xu;Hongqi Chen;Dijun Chen;Yang Sun |
| 16 | 环黄芪醇在制备治疗银屑病药物中的应用(授权专利) | 专利 | 孙洋;徐强;顾正兵;邓国亮;朱雨雨 |
| 17 | SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice | 期刊论文 | Wen Liu;Meijing Wang;Lihong Shen;Yuyu Zhu;Hongyue Ma;Bo Liu;Liang Ouyang;Wenjie Guo;Qiang Xu;Yang Sun |
| 18 | Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release. | 期刊论文 | Wen Liu;Ting Fan;Manru Li;Guohui Zhang;Wenjie Guo;Xiaoling Yang;Chunhong Jiang;Xiang Li;Xiangyu Xu;Anshu Tang;Keqin Liu;Lixuan Liu;Lingdong Kong;Qiang Xu;Yang Sun |
| 19 | Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies | 期刊论文 | Zhen-Dong Song;Mei-Jing Wang;Yang Ge;Xue-Ping Chen;Zi-Yang Xu;Yang Sun;Xiao-Feng Xiong |
| 20 | Targeting SHP2 as a promising strategy for cancer immunotherapy. | 期刊论文 | Jiao Qu;Qianqian Liu;Mingxia Zhao;Qiang Xu;Yang Sun |
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