缓释小分子化合物Kartogenin水凝胶重建软骨及软骨下骨缺损的机制研究
81730067
2017
H0604.骨、关节、软组织损伤与修复
蒋青
重点项目
教授
南京大学
295万元
软骨下骨重建;软骨缺损;软骨损伤与修复;透明质酸凝胶
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Inactivation of Lkb1 in postnatal chondrocytes leads to epiphyseal growth-plate abnormalities and promotes enchondroma-like formation | 期刊论文 | Sheng Zhou;Yixuan Li;Liang Qiao;Yuxiang Ge;Xiaojing Huang;Xiang Gao;Huangxian Ju;Wei Wangf;Junfeng Zhang;Jun Yan;Huajian Teng;Qing Jiang |
| 2 | The biomechanical changes of load distribution with longitudinal tears of meniscal horns on knee joint: a finite element analysis | 期刊论文 | Zhang Kaijia;Li Lan;Yang Longfei;Shi Jianping;Zhu Liya;Liang Huixin;Wang Xingsong;Yang Xianfeng;Jiang Qing |
| 3 | PEGylated gold nanoparticles promote Osteogenic differentiation in in vitro and in vivo systems | 期刊论文 | Yibo Zhang;Peng Wang;Huaijun Mao;Yangheng Zhang;Liming Zheng;Pengjun Yu;Zhirui Guo;Lan Li;Qing Jiang |
| 4 | Self-Cascade Uricase/Catalase Mimics Alleviate Acute Gout | 期刊论文 | Anqi Lin;Ziying Sun;Xingquan Xu;Sheng Zhao;Jiawei Li;Heng Sun;Quan Wang;Qing Jiang;Hui Wei;Dongquan Shi |
| 5 | Self-curling 3D oriented scaffolds from fish scales for skeletal muscle regeneration | 期刊论文 | Yong Shi;Xiaoxuan Zhang;Rui Liu;Xiaoyan Shao;Yuanjin Zhao;Zhuxiao Gu;Qing Jiang |
| 6 | Three-dimensional finite-element analysis of aggravating medial meniscus tears on knee osteoarthritis | 期刊论文 | Li Lan;Yang Longfei;Zhang Kaijia;Zhu Liya;Wang Xingsong;Jiang Qing |
| 7 | Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models | 期刊论文 | Li Lan;Shi Jianping;Zhang Kaijia;Yang Longfei;Yu Fei;Zhu Liya;Liang Huixin;Wang Xingsong;Jiang Qing |
| 8 | Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study | 期刊论文 | Ma Kaiwei;Zhao Tianzheng;Yang Longfei;Wang Peng;Jin Jing;Teng Huajian;Xia Dan;Zhu Liya;Li Lan;Jiang Qing;Wang Xingsong |
| 9 | Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome | 期刊论文 | Lei Zhang;Xiang Chen;Pingqiang Cai;Han Sun;Siyu Shen;Baosheng Guo;Qing Jiang |
| 10 | Nrf2 epigenetic derepression by running exercise alleviates osteoporosis | 期刊论文 | Xingren Chen;Xiaobo Zhu;Ai Wei;Fang Chen;Qi Gao;Ke Lu;Qing Jiang;Wangsen Cao |
| 11 | Trehalose enhances bone fracture healing in a rat sleep deprivation model | 期刊论文 | Xu Xingquan;Wang Rongliang;Sun Ziying;Wu Rui;Yan Wenjin;Jiang Qing;Shi Dongquan |
| 12 | Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment | 期刊论文 | Lei Zhang;Ziguo Qin;Han Sun;Xiang Chen;Jian Dong;Siyu Shen;Liming Zheng;Ning Gu;Qing Jiang |
| 13 | Effect of degenerative and radial tears of the meniscus and resultant meniscectomy on the knee joint: a finite element analysis | 期刊论文 | Zhang Kaijia;Li Lan;Yang Longfei;Shi Jianping;Zhu Liya;Liang Huixin;Wang Xingsong;Yang Xianfeng;Jiang Qing |
| 14 | Development of a novel polysaccharide-based iron oxide nanoparticle to prevent iron accumulation-related osteoporosis by scavenging reactive oxygen species. | 期刊论文 | Yu Pengjun;Zheng Liming;Wang Peng;Chai Senlin;Zhang Yibo;Shi Tianshu;Zhang Lei;Peng Rui;Huang Caoxing;Guo Baosheng;Jiang Qing |
| 15 | Intraarticular injection of SHP2 inhibitor SHP099 promotes the repair of rabbit full-thickness cartilage defect | 期刊论文 | Ziying Sun;Xingquan Xu;Zhongyang Lv;Jiawei Li;Tianshu Shi;Heng Sun;Kuoyang Sun;Guihua Tan;Wenqiang Yan;Yannick Xiaofan Yang;Rui Wu;Jia Xu;Hu Guo;Qing Jiang;Dongquan Shi |
| 16 | NRF2 is a critical regulator and therapeutic target of metal implant particle-incurred bone damage. | 期刊论文 | Jian Dong;Lijun Zhang;None Binjia Ruan;Zhongyang Lv;Hongwei Wang;Yongxiang Wang;Qing Jiang;Wangsen Cao |
| 17 | Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression | 期刊论文 | Ke Lu;Tian-Shu Shi;Si-Yu Shen;Yong Shi;Hong-Liang Gao;Jing Wu;Xiang Lu;Xiang Gao;Huang-xian Ju;Wei Wang;Yi Cao;Di Chen;Chao-Jun Li;Bin Xue;Qing Jiang |
| 18 | Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling | 期刊论文 | Ziying Sun;Qianqian Liu;Zhongyang Lv;Jiawei Li;Xingquan Xu;Heng Sun;Maochun Wang;Kuoyang Sun;Tianshu Shi;Zizheng Liu;Guihua Tan;Wenqiang Yan;Rui Wu;Yannick Xiaofan Yang;Shiro Ikegawa;Qing Jiang;Yang Sun;Dongquan Shi |
| 19 | Articular fibrocartilage-targeted therapy by microtubule stabilization | 期刊论文 | Jiawei Li;Huiming Jiang;Zhongyang Lv;Ziying Sun;Chaoqun Cheng;Guihua Tan;Maochun Wang;Anlong Liu;Heng Sun;Guo Hu;Fufei Chen;Zizheng Liu;Yuxiang Fei;Yaun Liu;Rui Wu;Xingquan Xu;Wenjin Yan;Qing Jiang;Dongquan Shi |
| 20 | Estrogen prevents articular cartilage destruction in a mouse model of AMPK deficiency via ERK-mTOR pathway | 期刊论文 | Ge Yuxiang;Zhou Sheng;Li Yixuan;Wang Zixu;Chen Shuai;Xia Tianwei;Shen Jirong;Teng Huajian;Jiang Qing |
| 21 | The changes of the calf-vein deformation and femoral vein peak velocity during ankle pump exercise with or without graduated compression stockings | 期刊论文 | Zaikai Zhuang;Dongmei Ai;Yao Yao;Liming Zheng;Jianghui Qin;Dongyang Chen;Senlin Chai;Jun Lu;Qing Jiang;Xinhua Li |
| 22 | Injectable, anti-inflammatory and conductive hydrogels based on graphene oxide and diacerein-terminated four-armed polyethylene glycol for spinal cord injury repair(Open Access) | 期刊论文 | Zhang Kaijia;Li Jiashuai;Jin Jing;Dong Jian;Li Lan;Xue Bin;Wang Wei;Jiang Qing;Cao Yi |
| 23 | Specific Clearance of Senescent Synoviocytes Suppresses the Development of Osteoarthritis based on Aptamer‐Functionalized Targeted Drug Delivery System | 期刊论文 | Xiang Chen;Lei Zhang;Xiaoyan Shao;Wang Gong;Tianshu Shi;Jian Dong;Yong Shi;Siyu Shen;Yi He;Jianghui Qin;Jun Lu;Qing Jiang;Baosheng Guo |
| 24 | An Injectable Hydrogel Scaffold With Kartogenin-Encapsulated Nanoparticles for Porcine Cartilage Regeneration: A 12-Month Follow-up Study | 期刊论文 | Wenqiang Yan;Xingquan Xu;Qian Xu;Ziying Sun;Zhongyang Lv;Rui Wu;Wenjin Yan;Qing Jiang;Dongquan Shi |
| 25 | Co-culture of hWJMSCs and pACs in double biomimetic ACECM oriented scaffold enhances mechanical properties and accelerates articular cartilage regeneration in a caprine model | 期刊论文 | Zhang Yu;Hao Chunxiang;Guo Weimin;Peng Xiaoyu;Wang Mingjie;Yang Zhen;Li Xu;Zhang Xueliang;Chen Mingxue;Sui Xiang;Peng Jiang;Lu Shibi;Liu Shuyun;Guo Quanyi;Jiang Qing |
| 26 | Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up | 期刊论文 | Wenqiang Yan;Xingquan Xu;Qian Xu;Ziying Sun;Qing Jiang;Dongquan Shi |
| 27 | PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice | 期刊论文 | Xiaobo Zhu;Fang Chen;Ke Lu;Ai Wei;Qing Jiang;Wangsen Cao |
| 28 | Injectable Photo-Crosslinked Bioactive BMSCs-BMP2-GelMA Scaffolds for Bone Defect Repair | 期刊论文 | Senlin Chai;Jianhao Huang;Abdurahman Mahmut;Bin Wang;Yao Yao;Xiaofeng Zhang;Zaikai Zhuang;Chunmei Xie;Zhihong Xu;Qing Jiang |
| 29 | TDP-43 maintains chondrocyte homeostasis and alleviates cartilage degradation in osteoarthritis | 期刊论文 | Liang Chang;Anlong Liu;Jia Xu;Xingquan Xu;Jin Dai;Rui Wu;Jin Dai;Rongliang Wang;Ziying Sun;Shiro Ikegawa;Qing Jiang;Dongquan Shi |
| 30 | Chondral Defects Cause Kissing Lesions in a Porcine Model | 期刊论文 | Wenqiang Yan;Xingquan Xu;Qian Xu;Ziying Sun;Zhongyang Lv;Rui Wu;Wenjin Yan;Qing Jiang;Dongquan Shi |
| 31 | Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFκB p65 pathway | 期刊论文 | Tianshu Shi;Yong Shi;Hongliang Gao;Yuze Ma;Qianjin Wang;Siyu Shen;Xiaoyan Shao;Wang Gong;Xiang Chen;Jian Qin;Jing Wu;Qing Jiang;Bin Xue |
| 32 | Stability evaluation of anterior external fixation in patient with unstable pelvic ring fracture: a finite element analysis | 期刊论文 | Li Lan;Lu Jingwei;Yang Longfei;Zhang Kaijia;Jin Jing;Sun Guojing;Wang Xingsong;Jiang Qing |
| 33 | Bone targeting antioxidative nano-iron oxide for treating postmenopausal osteoporosis | 期刊论文 | Liming Zheng;Zaikai Zhuang;Yixuan Li;Tianshu Shi;Kai Fu;Wenjin Yan;Lei Zhang;Peng Wang;Lan Li;Qing Jiang |
| 34 | Citrate-Stabilized Gold Nanorods-Directed Osteogenic Differentiation of Multiple Cells | 期刊论文 | Yibo Zhang;Yawen Li;Wei Liao;Wenzao Peng;Jianghui Qin;Dongyang Chen;Liming Zheng;Jin Dai;Lan Li;Zhirui Guo;Peng Wang;Qing Jiang |
| 35 | Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds | 期刊论文 | Li Lan;Li Yixuan;Yang Longfei;Yu Fei;Zhang Kaijia;Jin Jing;Shi Jianping;Zhu Liya;Liang Huixin;Wang Xingsong;Jiang Qing |
| 36 | TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway | 期刊论文 | Zhongyang Lv;Xingquan Xu;Ziying Sun;Yannick Xiaofan Yang;Hu Guo;Jiawei Li;Kuo-Yang Sun;Rui Wu;Jia Xu;Qing Jiang;Shiro Ikegawa;Dongquan Shi |
| 37 | Natural hydrogels for cartilage regeneration: Modification, preparation and application | 期刊论文 | Li Lan;Yu Fei;Zheng Liming;Wang Rongliang;Yan Wenqiang;Wang Zixu;Xu Jia;Wu Jianxiang;Shi Dongquan;Zhu Liya;Wang Xingsong;Jiang Qing |
| 38 | METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression | 期刊论文 | Xiang Chen;Wang Gong;Xiaoyan Shao;Tianshu Shi;Lei Zhang;Jian Dong;Yong Shi;Siyu Shen;Jianghui Qin;Qing Jiang;Baosheng Guo |
| 39 | 制备软骨缺损模型的钻具 | 专利 | 史冬泉;闫文强;蒋青;徐兴全;戴进 |
| 40 | Icaritin-Incorporated Porous Hollow Iron Oxide Nanostructures for Promoting Fracture Repair | 期刊论文 | Kaijia Zhang;Jian Dong;Jun Lu;Lan Li;Huan Liang;Jing Jin;Peng Wang;Xiaolian Sun;Qing Jiang |
| 41 | Evaluating the bio-application of biomacromolecule of lignin-carbohydrate complexes (LCC) from wheat straw in bone metabolism via ROS scavenging | 期刊论文 | Liming Zheng;Pengjun Yu;Yibo Zhang;Peng Wang;Jin Dai;Baosheng Guo;Caoxing Huang;Qing Jiang |
| 42 | Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1 | 期刊论文 | Li Jiawei;Wang Rongliang;Xu Jia;Sun Kuoyang;Jiang Huiming;Sun Ziying;Lv Zhongyang;Xu Xingquan;Wu Rui;Guo Hu;Jiang Qing;Shi Dongquan |
| 43 | 巴马小型猪股骨髁关节软骨及软骨下骨相关参数的测量 | 期刊论文 | 闫文强;徐兴全;许前;王荣亮;吴睿;蒋青;史冬泉 |
| 44 | Advances of injectable hydrogel-based scaffolds for cartilage regeneration | 期刊论文 | Li Jiawei;Chen Guojun;Xu Xingquan;Abdou Peter;Jiang Qing;Shi Dongquan;Gu Zhen |
| 45 | Biofabrication of a biomimetic supramolecular-polymer double network hydrogel for cartilage regeneration | 期刊论文 | Li Lan;Zhang Kaijia;Wang Tiankuo;Wang Peng;Xue Bin;Cao Yi;Zhu Liya;Jiang Qing |
| 46 | Trehalose reduces bone loss in experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation | 期刊论文 | Xingquan Xu;Rongliang Wang;Rui Wu;Wenjin Yan;Tianshu Shi;Qing Jiang;Dongquan Shi |
| 47 | 一种自体骨软骨移植专用工具 | 专利 | 史冬泉;闫文强;蒋青;徐兴全;戴进 |
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