Tau蛋白异常聚积引起神经细胞退变的分子机制研究
31730035
2017
C0903.神经系统结构与功能及异常
王建枝
重点项目
教授
华中科技大学
315万元
信号转导及转录激活因子-1;炎症;神经退变;阿尔茨海默病;NMDA受体
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms | 期刊论文 | Ying Yang;Jian-Zhi Wang |
| 2 | Tau acetylates and stabilizes β-catenin thereby promoting cell survival. | 期刊论文 | Enjie Liu;Qiuzhi Zhou;AoJi Xie;Xiaoguang Li;Mengzhu Li;Jinwang Ye;Shihong Li;Dan Ke;Qun Wang;ZhiPeng Xu;Li Li;Ying Yang;GongPing Liu;XiaoChuan Wang;HongLian Li;Jian-Zhi Wang |
| 3 | Illuminating Neural Circuits in Alzheimer’s Disease | 期刊论文 | Yang Ying;Jian-Zhi Wang |
| 4 | Tau accumulation triggers STAT1‐dependent memory deficits by suppressing NMDA receptor expression | 期刊论文 | Xiao‐Guang Li;Xiao‐Yue Hong;Ya‐li Wang;Shu‐Juan Zhang;Jun‐Fei Zhang;Xia‐Chun Li;Yan‐Chao Liu;Dong‐Shen Sun;Qiong Feng;Jin‐Wang Ye;Yuan Gao;Dan Ke;Qun Wang;Hong‐lian Li;Keqiang Ye;Gong‐Ping Liu;Jian‐Zhi Wang |
| 5 | Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy | 期刊论文 | Gao Yang;Zheng Jie;Jiang Tao;Pi Guilin;Sun Fei;Xiong Rui;Wang Weijin;Wu Dongqin;Li Shihong;Lei Huiyang;Yu Huiling;Zhou Qiuzhi;Yang Ying;Zhang Huaqiu;Wang Jian-Zhi |
| 6 | Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity | 期刊论文 | Yuan Gao;En-Jie Liu;Wei-Jin Wang;Ya-Li Wang;Xiao-Guang Li;Xin Wang;Shi-Hong Li;Shu-Juan Zhang;Meng-Zhu Li;Qiu-Zhi Zhou;Xiao-Bing Long;Hua-Qiu Zhang;Jian-Zhi Wang |
| 7 | Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. | 期刊论文 | Zheng Jie;Hong-Lian Li;Na Tian;Fei Liu;Lu Wang;Yaling Yin;Lupeng Yue;Longyu Ma;You Wan;Jian-Zhi Wang |
| 8 | Co-Expression of Three Wild-Type 3R-Tau Isoforms Induces Memory Deficit via Oxidation-Related DNA Damage and Cell Death: A Promising Model for Tauopathies | 期刊论文 | Xu Cheng;Guo Jing;Li Li;Wang Xin;Zhou Qiuzhi;Sun Dongsheng;Zhang Shujuan;Li Shihong;Ye Jinwang;Liu Yanchao;Liu Enjie;Zeng Peng;Wang Xiaochuan;Yang Ying;Wang Jian-Zhi |
| 9 | A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies | 期刊论文 | Zheng Jie;Tian Na;Liu Fei;Zhang Yidian;Su Jingfen;Gao Yang;Deng Mingmin;Wei Linyu;Ye Jingwang;Li Honglian;Wang Jianzhi |
| 10 | A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models | 期刊论文 | Weijin Wang;Qiuzhi Zhou;Tao Jiang;Shihong Li;Jinwang Ye;Jie Zheng;Xin Wang;Yanchao Liu;Minmin Deng;Dan Ke;Qun Wang;Yipeng Wang;Jian-Zhi Wang |
| 11 | MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. | 期刊论文 | Qiong Feng;Yu Luo;Xiang-Nan Zhang;Xi-Fei Yang;Xiao-Yue Hong;Dong-Sheng Sun;Xia-Chun Li;Yu Hu;Xiao-Guang Li;Jun-Fei Zhang;Xiao Li;Ying Yang;Qun Wang;Gong-Ping Liu;Jian-Zhi Wang |
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