RP2/视杆细胞光转导蛋白/视网膜色素变性致病机制
31571303
2015
C0604.表型、行为与疾病的遗传学基础
唐朝晖
面上项目
教授级高级工程师
华中科技大学
63万元
分子机制;光转导;视网膜变性;定量蛋白组学;RP2
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy | 期刊论文 | Lu Zhaojing;Hu Xuebin;Liu Fei;Soares Dinesh C.;Liu Xiliang;Yu Shanshan;Gao Meng;Han Shanshan;Qin Yayun;Li Chang;Jiang Tao;Luo Daji;Guo An-Yuan;Tang Zhaohui;Liu Mugen |
| 2 | Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish | 期刊论文 | Xie Shanglun;Han Shanshan;Qu Zhen;Liu Fei;Li Jingzhen;Yu Shanshan;Reilly James;Tu Jiayi;Liu Xiliang;Lu Zhaojing;Hu Xuebin;Yimer Tinsae Assefa;Qin Yayun;Huang Yuwen;Lv Yuexia;Jiang Tao;Shu Xinhua;Tang Zhaohui;Jia Haibo;Wong Fulton;Liu Mugen |
| 3 | Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration | 期刊论文 | Lu Zhaojing;Hu Xuebin;Reilly James;Jia Danna;Liu Fei;Yu Shanshan;Liu Xiliang;Xie Shanglun;Qu Zhen;Qin Yayun;Huang Yuwen;Lv Yuexia;Li Jingzhen;Gao Pan;Wong Fulton;Shu Xinhua;Tang Zhaohui;Liu Mugen |
| 4 | BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis | 期刊论文 | Yu Shanshan;Jiang Tao;Jia Danna;Han Yundiao;Liu Fei;Huang Yuwen;Qu Zhen;Zhao Yuntong;Tu Jiayi;Lv Yuexia;Li Jingzhen;Hu Xuebin;Lu Zhaojing;Han Shanshan;Qin Yayun;Liu Xiliang;Xie Shanglun;Wang Qing K.;Tang Zhaohui;Luo Daji;Liu Mugen |
| 5 | Identification of a novel NRL mutation in a Chinese family with retinitis pigmentosa by whole-exome sequencing | 期刊论文 | Y Qin;F Liu;S Yu;L Yang;M Gao;Z Tang;AY Guo;M Zhang;P Li;M Liu |
| 6 | Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish | 期刊论文 | Liu Fei;Qin Yayun;Yu Shanshan;Soares Dinesh C.;Yang Lifang;Weng Jun;Li Chang;Gao Meng;Lu Zhaojing;Hu Xuebin;Liu Xiliang;Jiang Tao;Liu Jing Yu;Shu Xinhua;Tang Zhaohui;Liu Mugen |
| 7 | BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination | 期刊论文 | Liao Shengjie;Du Rong;Wang Lei;Qu Zhen;Cui Xiukun;Li Chang;Liu Fei;Huang Mi;Wang Jiuxiang;Chen Jiaxiang;Gao Meng;Yu Shanshan;Tang Zhaohui;Li David Wan-Cheng;Jiang Tao;Liu Mugen |
| 8 | CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish | 期刊论文 | Yu Shanshan;Li Chang;Biswas Lincoln;Hu Xuebin;Liu Fei;Reilly James;Liu Xiliang;Liu Ying;Huang Yuwen;Lu Zhaojing;Han Shanshan;Wang Lei;Liu Jing Yu;Jiang Tao;Shu Xinhua;Wong Fulton;Tang Zhaohui;Liu Mugen |
| 9 | Whole exome sequencing identifies a novel NRL mutation in a Chinese family with autosomaldominant retinitis pigmentosa | 期刊论文 | Meng Gao;Zhang Su;Liu Chunjie;Qin Yayun;Stephen Archacki;Ling Jin;Wang Yong;Liu Fei;Chen Jiaxiang;Liu Ying;Wang Jiuxiang;Huang Mi;Zhaohui Tang;Guo Anyuan;Fagang Jiang;Liu Mugen |
| 10 | Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy | 期刊论文 | Han Shanshan;Liu Xiliang;Xie Shanglun;Gao Meng;Liu Fei;Yu Shanshan;Sun Peng;Wang Changquan;Archacki Stephen;Lu Zhaojing;Hu Xuebin;Qin Yayun;Qu Zhen;Huang Yuwen;Lv Yuexia;Tu Jiayi;Li Jingzhen;Yimer Tinsae Assefa;Jiang Tao;Tang Zhaohui;Luo Daji;Chen Fangyi;Liu Mugen |
| 11 | Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking | 期刊论文 | Qu Zhen;Yimer Tinsae Assefa;Xie Shanglun;Wong Fulton;Yu Shanshan;Liu Xiliang;Han Shanshan;Ma Juanjuan;Lu Zhaojing;Hu Xuebin;Qin Yayun;Huang Yuwen;Lv Yuexia;Li Jingzhen;Tang Zhaohui;Liu Fei;Liu Mugen |
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