基于家系的新一代测序探索冠心病分子遗传基础
31430047
2014
C0607.基因组学
王擎
重点项目
教授
华中科技大学
327万元
易感基因;冠心病;全外显子测序;全基因组连锁分析;致病基因
2015-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Identification of Rare Variants in TNNI3 with Atrial Fibrillation in a Chinese GeneID Population | 期刊论文 | Wang C;Wu M;Qian J;Li B;Tu X;Xu C;Li S;Chen S;Zhao Y;Huang Y;Shi L;Cheng X;Liao Y;Chen Q;Xia Y;Yao W;Wu G;Cheng M;Wang QK |
| 2 | Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population | 期刊论文 | Wang Pengyun; Xu Chengqi; Wang Chuchu; Wu Yanxia; Wang Dan; Chen Shanshan; Zhao Yuanyuan; Wang Xiaojing; Li Sisi; Yang Qin; Zeng Qiutang; Tu Xin; Liao Yuhua; Wang Qing K; Cheng Xiang |
| 3 | Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke | 期刊论文 | Xiong Xin;Naji Duraid Hamied;Wang Binbin;Zhao Yuanyuan;Wang Junhan;Wang Dan;Zhang Yuting;Li Sisi;Chen Shanshan;Huang Yufeng;Yang Qin;Wang Xiaojing;Yin Dan;Tu Xin;Chen Qiuyun;Ma Xu;Xu Chengqi;Wang Qing K. |
| 4 | Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury | 期刊论文 | Yao Yufeng;Hu Zhenkun;Ye Jian;Hu Changqing;Song Qixue;Da Xingwen;Yu Yubin;Li Hui;Xu Chengqi;Chen Qiuyun;Wang Qing Kenneth |
| 5 | Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis. | 期刊论文 | Wang Li;Wang Xiaojing;Wang Longfei;Yousaf Muhammad;Li Jia;Zuo Mengxia;Yang Zhongcheng;Gou Dongzhi;Bao Binghao;Li Lei;Xiang Ning;Jia Haibo;Xu Chengqi;Chen Qiuyun;Wang Qing Kenneth |
| 6 | A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure | 期刊论文 | Yao Yufeng;Lu Qiulun;Hu Zhenkun;Yu Yubin;Chen Qiuyun;Wang Qing K. |
| 7 | UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density. | 期刊论文 | Tang Bo;Hu Yushuang;Wang Zhijie;Cheng Chen;Wang Pengyun;Liang Lina;Xiong Hongbo;Luo Chunyan;Xu Chengqi;Chen Qiuyun;Wang Qing Kenneth |
| 8 | NINJ2- A novel regulator of endothelial inflammation and activation | 期刊论文 | Wang Jingjing;Fa Jingjing;Wang Pengyun;Jia Xinzhen;Peng Huixin;Chen Jing;Wang Yifan;Wang Chenhui;Chen Qiuyun;Tu Xin;Wang Qing K.;Xu Chengqi |
| 9 | αB-Crystallin Interacts with Nav1. 5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1. 5 | 期刊论文 | Huang Y;Wang Z;Liu Y;Xiong H;Zhao Y;Wu L;Yuan C;Wang L;Hou Y;Yu G;Huang Z;Xu C;Chen Q;Wang QK |
| 10 | Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model | 期刊论文 | Lu Qiulun; Yao Yihong; Yao Yufeng; Liu Shizhi; Huang Yuan; Lu Shan; Bai Ying; Zhou Bisheng; Xu Yan; Li Lei; Wang Nan; Wang Li; Zhang Jie; Cheng Xiang; Qin Gangjian; Ma Wei; Xu Chengqi; Tu Xin; Wang Qing |
| 11 | Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease. | 期刊论文 | Yin Dan;Naji Duraid Hamied;Xia Yunlong;Li Sisi;Bai Ying;Jiang Guiqing;Zhao Yuanyuan;Wang Xiaojing;Huang Yufeng;Chen Shanshan;Fa Jingjing;Tan Chengcheng;Zhou Mengchen;Zhou Yingchao;Wang Longfei;Liu Ying;Chen Feifei;Liu Jingqiu;Chen Qiuyun;Tu Xin;Xu Chengqi;Wang Qing K |
| 12 | Mutation in NPPA causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock-in rat model. | 期刊论文 | Cheng Chen;Liu Huixia;Tan Chengcheng;Tong Doudou;Zhao Yongxuan;Liu Xia;Si Wenxia;Wang Linlin;Liang Lina;Li Jia;Wang Chenghui;Chen Qiuyun;Du Yimei;Wang Qing K;Ren Xiang |
| 13 | Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5. | 期刊论文 | Wang Zhijie;Yu Gang;Liu Yinan;Liu Shiyong;Aridor Meir;Huang Yuan;Hu Yushuang;Wang Longfei;Li Sisi;Xiong Hongbo;Tang Bo;Li Xia;Cheng Chen;Chakrabarti Susmita;Wang Fan;Wu Qingyu;Karnik Sadashiva S;Xu Chengqi;Chen Qiuyun;Wang Qing K |
| 14 | Significant Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a Chinese Han Population | 期刊论文 | Chen S;Wang C;Wang X;Xu C;Wu M;Wang P;Tu X;Wang QK |
| 15 | ADAMTS16 Activates Latent TGF-beta, Accentuating Fibrosis and Dysfunction of the Pressure-overloaded Heart. | 期刊论文 | Yao Yufeng;Hu Changqing;Song Qixue;Li Yong;Da Xingwen;Yu Yubin;Li Hui;Clark Ian M;Chen Qiuyun;Wang Qing K |
| 16 | Significant genetic association of a functional TFPI variant with circulating fibrinogen levels and coronary artery disease. | 期刊论文 | Naji Duraid Hamid;Tan Chengcheng;Han Fabin;Zhao Yuanyuan;Wang Junhan;Wang Dan;Fa Jingjing;Li Sisi;Chen Shanshan;Chen Qiuyun;Xu Chengqi;Wang Qing K |
| 17 | Angiotensin II increases angiogenesis by NF-kappaB-mediated transcriptional activation of angiogenic factor AGGF1. | 期刊论文 | Si Wenxia;Xie Wen;Deng Wenbing;Xiao Yi;Karnik Sadashiva S;Xu Chengqi;Chen Qiuyun;Wang Qing Kenneth |
| 18 | Significant association of rare variant p.Gly8Ser in cardiac sodium channel beta4-subunit SCN4B with atrial fibrillation. | 期刊论文 | Xiong Hongbo;Yang Qin;Zhang Xiaoping;Wang Pengxia;Chen Feifei;Liu Ying;Wang Pengyun;Zhao Yuanyuan;Li Sisi;Huang Yufeng;Chen Shanshan;Wang Xiaojing;Zhang Hongfu;Yu Dong;Tan Chencheng;Fang Cheng;Huang Yuan;Wu Gang;Wu Yanxia;Cheng Xiang;Liao Yuhua;Zhang Rongfeng;Yang Yanzong;Ke Tie;Ren Xiang;Li Hui;Tu Xin;Xia Yunlong;Xu Chengqi;Chen Qiuyun;Wang Qing K |
| 19 | Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin | 期刊论文 | Zhang T;Yao Y;Wang J;Li Y;He P;Vinay Pasupuleti;Hu Z;Jia X;Song Q;Tian X;Chen Q;Wang QK |
| 20 | Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation | 期刊论文 | Huang Yufeng;Wang Chuchu;Yao Yufeng;Zuo Xiaoyu;Chen Shanshan;Xu Chengqi;Zhang Hongfu;Lu Qiulun;Chang Le;Wang Fan;Wang Pengxia;Zhang Rongfeng;Hu Zhenkun;Song Qixue;Yang Xiaowei;Li Cong;Li Sisi;Zhao Yuanyuan;Yang Qin;Yin Dan;Wang Xiaojing;Si Wenxia;Li Xiuchun;Xiong Xin;Wang Dan;Huang Yuan;Luo Chunyan;Li Jia;Wang Jingjing;Chen Jing;Wang Longfei;Wang Li;Han Meng;Ye Jian... |
| 21 | Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease | 期刊论文 | Luo Chunyan;Wang Fan;Ren Xiang;Ke Tie;Xu Chengqi;Tang Bo;Qin Subo;Yao Yufeng;Chen Qiuyun;Wang Qing Kenneth |
| 22 | De novo BK channel variant causes epilepsy by affecting voltage gating but not Ca(2+) sensitivity. | 期刊论文 | Li Xia;Poschmann Sibylle;Chen Qiuyun;Fazeli Walid;Oundjian Nelly Jouayed;Snoeijen-Schouwenaars Francesca M;Fricke Oliver;Kamsteeg Erik-Jan;Willemsen Marjolein;Wang Qing Kenneth |
| 23 | Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression | 期刊论文 | Ye J;Yao Y;Song Q;Li S;Hu Z;Yu Y;Hu C;Da X;Li H;Chen Q;Wang QK |
| 24 | Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Nav1.5 clarify the molecular basis of Brugada syndrome. | 期刊论文 | Yu Gang;Liu Yinan;Qin Jun;Wang Zhijie;Hu Yushuang;Wang Fan;Li Yabo;Chakrabarti Susmita;Chen Qiuyun;Wang Qing Kenneth |
| 25 | Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation. | 期刊论文 | Wang Pengxia;Qin Weixi;Wang Pengyun;Huang Yufeng;Liu Ying;Zhang Rongfeng;Li Sisi;Yang Qin;Wang Xiaojing;Chen Feifei;Liu Jingqiu;Yang Bo;Cheng Xiang;Liao Yuhua;Wu Yanxia;Ke Tie;Tu Xin;Ren Xiang;Yang Yanzong;Xia Yunlong;Luo Xiaoping;Liu Mugen;Li He;Liu Jingyu;Xiao Yi;Chen Qiuyun;Xu Chengqi;Wang Qing K |
| 26 | 抑制心肌肥厚的重组蛋白基因及其表达产物和应用 | 专利 | 王擎;姚雨峰;陈秋云 |
| 27 | Angiogenic Factor AGGF1-Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice. | 期刊论文 | Yao Yufeng;Li Yong;Song Qixue;Hu Changqin;Xie Wen;Xu Chengqi;Chen Qiuyun;Wang Qing K |
| 28 | 一种重组蛋白及其应用 | 专利 | 王擎;姚雨峰;吕丘仑 |
| 29 | Identification of rare variants in cardiac sodium channel beta4-subunit gene SCN4B associated with ventricular tachycardia. | 期刊论文 | Yang Qin;Xiong Hongbo;Xu Chengqi;Huang Yuan;Tu Xin;Wu Gang;Fu Fenfen;Wang Zhijie;Wang Longfei;Zhao Yuanyuan;Li Sisi;Huang Yufeng;Wang Chuchu;Wang Dan;Yao Yufeng;Wang Fan;Wang Yongbo;Xue Yu;Wang Pengyun;Chen Qiuyun;Pu Jielin;Wang Qing K |
| 30 | SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension. | 期刊论文 | Yao Yufeng;Li Hui;Da Xinwen;He Zuhan;Tang Bo;Li Yong;Hu Changqing;Xu Chengqi;Chen Qiuyun;Wang Qing K |
| 31 | phlda3 overexpression impairs specification of hemangioblasts and vascular development. | 期刊论文 | Wang Xiaojing;Li Jia;Yang Zhongcheng;Wang Li;Li Lei;Deng Wenqing;Zhou Juan;Wang Longfei;Xu Chengqi;Chen Qiuyun;Wang Qing K |
| 32 | Losartan protects against myocardial ischemia and reperfusion injury via vascular integrity preservation. | 期刊论文 | Li Yong;Yao Yufeng;Li Jia;Chen Qiuyun;Zhang Lu;Wang Qing K |
| 33 | Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation and apoptosis by global gene expression regulatio | 期刊论文 | Luo C;Wang F;Qin S;Chen Q;Wang Q |
| 34 | Identification of a mutation in CNNM4 by whole exome sequencing in an Amish family and functional link between CNNM4 and IQCB1 | 期刊论文 | Li Sisi;Xi Quansheng;Zhang Xiaoyu;Yu Dong;Li Lin;Jiang Zhenyang;Chen Qiuyun;Wang Qing K.;Traboulsi Elias I. |
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