纳米孔测序分析及其在精准识别碱基损伤与修饰碱基中的应用范例
31972917
2019
C0502.分子生物物理
黄硕
面上项目
教授
南京大学
59万元
DNA修饰;DNA测序;碱基损伤;纳米孔;生物孔道
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Single Molecule Tools for Bioanalysis | 专著 | Huang Shuo（主持编撰） |
| 2 | Preparation of Mycobacterium smegmatis porin A (MspA) nanopores for single molecule sensing of nucleic acids | 期刊论文 | Wang Yuqin;Fan Pingping;Zhang Shanyu;Yan Shuanghong;Huang Shuo |
| 3 | Single Molecule Ratcheting Motion of Peptides in a Mycobacterium smegmatis Porin A (MspA) Nanopore | 期刊论文 | Yan Shuanghong;Zhang Jinyue;Wang Yu;Guo Weiming;Zhang Shanyu;Liu Yao;Cao Jiao;Wang Yuqin;Wang Liying;Ma Fubo;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 4 | Single molecule identification with a reactive hetero-nanopore | 专利 | Huang Shuo;Zhang Shanyu;Wang Kefan;Wang Yuqin;Liu Yao |
| 5 | Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore | 期刊论文 | Kefan Wang;Shanyu Zhang;Xiao Zhou;Xian Yang;Xinyue Li;Yuqin Wang;Pingping Fan;Yunqi Xiao;Wen Sun;Panke Zhang;Wenfei Li;Shuo Huang |
| 6 | Structural-profiling of analytes by nanopore trapping | 专利 | Huang Shuo;Liu Yao;Wang Yuqin;Zhang Shanyu |
| 7 | Identification of Single-Molecule Catecholamine Enantiomers Using a Programmable Nanopore | 期刊论文 | Wendong Jia;Chengzhen Hu;Yuqin Wang;Yao Liu;Liying Wang;Shanyu Zhang;Qiang Zhu;Yuming Gu;Panke Zhang;Jing Ma;Hong-Yuan Chen;Shuo Huang |
| 8 | Nanopore Sequencing Accurately Identifies the Cisplatin Adduct on DNA | 期刊论文 | Ma Fubo;Yan Shuanghong;Zhang Jinyue;Wang Yu;Wang Liying;Wang Yuqin;Zhang Shanyu;Du Xiaoyu;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 9 | 嵌合型纳米孔道 | 专利 | 黄硕;谢然;杨晶;王可凡;陈佳璐 |
| 10 | Microscopic Screening of Cyclodextrin Channel Blockers by DiffusiOptoPhysiology | 期刊论文 | Du Xiaoyu;Wang Yuqin;Zhang Shanyu;Fan Pingping;Yan Shuanghong;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 11 | Allosteric Switching of Calmodulin in a Mycobacterium smegmatis porin A (MspA) Nanopore-Trap | 期刊论文 | Liu Yao;Pan Tiezheng;Wang Kefan;Wang Yuqin;Yan Shuanghong;Wang Liying;Zhang Shanyu;Du Xiaoyu;Jia Wendong;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 12 | Single‐Molecule Sensing of Acidic Catecholamine Metabolites Using a Programmable Nanopore | 期刊论文 | Chengzhen Hu;Wendong Jia;Yao Liu;Yuqin Wang;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
| 13 | Single-Molecule Interconversion between Chiral Configurations of Boronate Esters Observed in a Nanoreactor | 期刊论文 | Xiaoyu Du;Shanyu Zhang;Liying Wang;Yuqin Wang;Pingping Fan;Wendong Jia;Panke Zhang;Shuo Huang |
| 14 | Programmable nano-reactors for stochastic sensing | 期刊论文 | Jia Wendong;Hu Chengzhen;Wang Yuqin;Gu Yuming;Qian Guangrui;Du Xiaoyu;Wang Liying;Liu Yao;Cao Jiao;Zhang Shanyu;Yan Shuanghong;Zhang Panke;Ma Jing;Chen Hong-Yuan;Huang Shuo |
| 15 | Single molecule observation of hard-soft-acid-base (HSAB) interaction in engineered Mycobacterium smegmatis porin A (MspA) nanopores | 期刊论文 | Wang Sha;Cao Jiao;Jia Wendong;Guo Weiming;Yan Shanghong;Wang Yuqin;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 16 | Non-binary Encoded Nucleic Acid Barcodes Directly Readable by a Nanopore | 期刊论文 | Shuanghong Yan;Liying Wang;Yuqin Wang;Zhenyuan Cao;Shanyu Zhang;Xiaoyu Du;Pingping Fan;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
| 17 | Mapping Potential Engineering Sites of Mycobacterium smegmatis porin A (MspA) to Form a Nanoreactor | 期刊论文 | Zhang Jinyue;Cao Jiao;Jia Wendong;Zhang Shanyu;Yan Shuanghong;Wang Yuqin;Zhang Panke;Chen Hong-Yuan;Li Wenfei;Huang Shuo |
| 18 | 利用反应性异质纳米孔鉴定甲状腺激素 | 专利 | 黄硕;王可凡;杨娴 |
| 19 | Retarded Translocation of Nucleic Acids through α-Hemolysin Nanopore in the Presence of a Calcium Flux | 期刊论文 | Wang Sha;Wang Yuqin;Yan Shuanghong;Du Xiaoyu;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 20 | A Nanopore Based Molnupiravir Sensor | 期刊论文 | Wendong Jia;Chengzhen Hu;Yuqin Wang;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
| 21 | Discrimination between Different DNA Lesions by Monitoring Single-Molecule Polymerase Stalling Kinetics during Nanopore Sequencing. | 期刊论文 | Jinyue Zhang;Yu Wang;Yuqin Wang;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
| 22 | Site‐Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion | 期刊论文 | Jing Yang;Kefan Wang;Shanyu Zhang;Xiaocui Zheng;Tongxiao Cui;Xian Yang;Yao Liu;Di Lu;Yuqin Wang;Xiao Tian;Panke Zhang;Shuo Huang;Ran Xie |
| 23 | A Nanopore‐Based Saccharide Sensor | 期刊论文 | Shanyu Zhang;Zhenyuan Cao;Pingping Fan;Yuqin Wang;Wendong Jia;Liying Wang;Kefan Wang;Yao Liu;Xiaoyu Du;Chengzhen Hu;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
| 24 | Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore. | 期刊论文 | Cao Jiao;Jia Wendong;Zhang Jinyue;Xu Xiumei;Yan Shuanghong;Wang Yuqin;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 25 | Direct microRNA sequencing using Nanopore Induced Phase-Shift Sequencing (NIPSS) | 期刊论文 | Zhang Jinyue;Yan Shuanghong;Chang Le;Guo Weiming;Wang Yuqin;Wang Yu;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 26 | Nanopore Discrimination of Nucleotide Sugars | 期刊论文 | Kefan Wang;Xian Yang;Shanyu Zhang;Panke Zhang;Shuo Huang |
| 27 | Detection of analytes by nanopore without using electrodes. | 专利 | Huang Shuo;Wang Yuqin |
| 28 | Direct microRNA sequencing using enzyme assisted sequencing | 专利 | Huang Shuo;Zhang Jinyue;Yan Shuanghong |
| 29 | Nanopore Signatures of Nucleoside Drugs | 期刊论文 | Wendong Jia;Yusheng Ouyang;Shanyu Zhang;Xiaoyu Du;Panke Zhang;Shuo Huang |
| 30 | Machine Learning Assisted Simultaneous Structural Profiling of Differently Charged Proteins in a Mycobacterium smegmatis Porin A (MspA) Electroosmotic Trap | 期刊论文 | Yao Liu;Kefan Wang;Yuqin Wang;Liying Wang;Shuanghong Yan;Xiaoyu Du;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
| 31 | A Single-Molecule Observation of Dichloroaurate(I) Binding to an Engineered Mycobacterium smegmatis porin A (MspA) Nanopore | 期刊论文 | Cao Jiao;Zhang Shanyu;Zhang Jinyue;Wang Sha;Jia Wendong;Yan Shuanghong;Wang Yuqin;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 32 | Discrimination of ribonucleoside mono-, di-, and triphosphates using an engineered nanopore | 期刊论文 | Yuqin Wang;Pingping Fan;Shanyu Zhang;Liying Wang;Xinyue Li;Wendong Jia;Yao Liu;Kefan Wang;Xiaoyu Du;Panke Zhang;Shuo Huang |
| 33 | Programmable Nano-Reactors for Stochastic Sensing (PNRSS) | 专利 | Huang Shuo;Jia Wendong |
| 34 | Structural-profiling of low molecular weight RNAs by nanopore trapping/translocation using Mycobacterium smegmatis porin A | 期刊论文 | Wang Yuqin;Guan Xiaoyu;Zhang Shanyu;Liu Yao;Wang Sha;Fan Pingping;Du Xiaoyu;Yan Shuanghong;Zhang Panke;Chen Hong-Yuan;Li Wenfei;Zhang Daoqiang;Huang Shuo |
| 35 | 纳米孔测序技术在核酸修饰检测中的应用 | 期刊论文 | 陈佳璐;黄硕 |
| 36 | Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore | 期刊论文 | Yuqin Wang;Shanyu Zhang;Wendong Jia;Pingping Fan;Liying Wang;Xinyue Li;Jialu Chen;Zhenyuan Cao;Xiaoyu Du;Yao Liu;Kefan Wang;Chengzhen Hu;Jinyue Zhang;Jun Hu;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
| 37 | Rapid and multiplex preparation of engineered Mycobacterium smegmatis porin A (MspA) nanopores for single molecule sensing and sequencing | 期刊论文 | Yan Shuanghong;Wang Liying;Du Xiaoyu;Zhang Shanyu;Wang Sha;Cao Jiao;Zhang Jinyue;Jia Wendong;Wang Yuqin;Zhang Panke;Chen Hong-Yuan;Huang Shuo |
| 38 | Nanopore Identification of Alditol Epimers and Their Application in Rapid Analysis of Alditol-Containing Drinks and Healthcare Products | 期刊论文 | Yao Liu;Shanyu Zhang;Yuqin Wang;Liying Wang;Zhenyuan Cao;Wen Sun;Pingping Fan;Panke Zhang;Hong-Yuan Chen;Shuo Huang |
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